{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T15:49:26Z","timestamp":1693583366030},"reference-count":42,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p>RACIONAL: A metaplasia intestinal especializada pode ser classificada, de acordo com os achados endosc\u00f3picos e histol\u00f3gicos, em Barrett longo, Barrett curto e metaplasia intestinal da c\u00e1rdia. O es\u00f4fago de Barrett \u00e9 doen\u00e7a adquirida que ocorre em aproximadamente 10% a 13% dos indiv\u00edduos com doen\u00e7a do refluxo gastroesof\u00e1gico e representa uma condi\u00e7\u00e3o pr\u00e9-neopl\u00e1sica. \u00c9 caracterizado por substitui\u00e7\u00e3o do epit\u00e9lio escamoso estratificado pelo metapl\u00e1sico colunar especializado, contendo c\u00e9lulas caliciformes. OBJETIVOS: Determinar, prospectivamente, a preval\u00eancia e as caracter\u00edsticas cl\u00ednico-epidemiol\u00f3gicas da metaplasia intestinal especializada de es\u00f4fago distal na doen\u00e7a do refluxo gastroesof\u00e1gico. M\u00c9TODOS: Entre abril e outubro de 2002, 402 pacientes com sintomas da doen\u00e7a do refluxo gastroesof\u00e1gico foram avaliados atrav\u00e9s de question\u00e1rio padronizado que abordava as vari\u00e1veis demogr\u00e1ficas e foram submetidos a exame endosc\u00f3pico com biopsias 1 cm abaixo da jun\u00e7\u00e3o escamocolunar, nos quatro quadrantes. RESULTADOS: Metaplasia intestinal especializada foi encontrada em 18,4% dos pacientes: 0,5% Barrett longo, 3,2% Barrett curto e 14,7% metaplasia intestinal da c\u00e1rdia. Houve tend\u00eancia de maior n\u00famero de homens apresentando es\u00f4fago de Barrett e mulheres com metaplasia intestinal da c\u00e1rdia. Todos com es\u00f4fago de Barrett eram da ra\u00e7a branca. N\u00e3o houve rela\u00e7\u00e3o entre a intensidade dos sintomas da doen\u00e7a do refluxo gastroesof\u00e1gico e a presen\u00e7a de metaplasia intestinal especializada. O tempo de dura\u00e7\u00e3o de sintomas superior a 5 anos foi uma tend\u00eancia nos portadores de es\u00f4fago de Barrett. Este grupo tamb\u00e9m apresentou mais h\u00e9rnia de hiato e esofagite mais intensa do que aqueles com metaplasia intestinal da c\u00e1rdia. N\u00e3o houve rela\u00e7\u00e3o entre uso de tabaco ou \u00e1lcool e metaplasia intestinal especializada. CONCLUS\u00d5ES: Es\u00f4fago de Barrett foi mais relacionado ao sexo masculino, com sintomas de longa cronicidade, esofagite mais intensa e sem associa\u00e7\u00e3o com tabaco ou \u00e1lcool.<\/jats:p>","DOI":"10.1590\/s0004-28032003000400005","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:21:00Z","timestamp":1113574860000},"page":"220-226","source":"Crossref","is-referenced-by-count":7,"title":["Metaplasia intestinal especializada de es\u00f4fago distal na doen\u00e7a do refluxo gastroesof\u00e1gico: preval\u00eancia e aspectos cl\u00ednico-epidemiol\u00f3gicos"],"prefix":"10.1590","volume":"40","author":[{"given":"Leiber C.","family":"Caum","sequence":"first","affiliation":[{"name":"Universidade Federal do Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio L.","family":"Bizinelli","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falio C\u00e9sar","family":"Pisani","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1; Universidade Federal do Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heda Maria Barska dos Santos","family":"Amarantes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio O.","family":"Ioshii","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliane R.","family":"Carmes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"A43","DOI":"10.1016\/0016-5085(95)22834-9","article-title":"Prevalence of short segment Barrett's 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