{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T16:29:28Z","timestamp":1648744168018},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p>BACKGROUND: Esomeprazole, an S-isomer of omeprazole, is the first proton pump inhibitor developed as an optical isomer, and it has shown high healing rates in erosive esophagitis. AIM: To evaluate the efficacy and tolerability of esomeprazole in subjects with erosive esophagitis, according to the Los Angeles classification study design: an open, multi-center clinical study. MATERIAL AND METHODS: Two hundred and eighteen subjects with reflux esophagitis confirmed by endoscopy were included in an open, multi-center study in Brazil. All of them received esomeprazole 40 mg, once daily, for a 4-week period. Subjects who had unhealed esophagitis by week 4 continued the treatment for another 4 weeks. The primary efficacy endpoint was the healing rates by weeks 4 and 8. The secondary endpoints were the number of patients with symptom resolution by week 4, the number of days to sustained symptom resolution, number of symptom-free days and nights and safety and tolerability of the drug. RESULTS: Healing rates by weeks 4 and 8 were 82% (confidence interval: 77.4%-87.6%) and 96.1% (confidence interval: 93.5% - 98.8%), respectively. Ninety-nine (99%) of the patients had heartburn resolution by week 2. The most common adverse events were headache (4%), diarrhea (2.6%) and epigastric pain (2.2%). CONCLUSION: For the studied period, esomeprazole was shown to be a safe and well-tolerated drug, providing significant healing rates of mucosal breaks, regardless of LA classification, in patients with erosive esophagitis. Esomeprazole was also shown to be effective in quickly relieving symptoms.<\/jats:p>","DOI":"10.1590\/s0004-28032003000400012","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:21:00Z","timestamp":1113574860000},"page":"262-267","source":"Crossref","is-referenced-by-count":0,"title":["Clinical and endoscopic evaluantion of gastroesophageal reflux disease in patients successfully treated with esomeprazole"],"prefix":"10.1590","volume":"40","author":[{"given":"Edson Pedro da","family":"Silva","sequence":"first","affiliation":[{"name":"Universidade Regional de Blumenau; Espa\u00e7o de Sa\u00fade do Aparelho Digestivo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farid","family":"Nader","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio A.","family":"Quilici","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime Natan","family":"Eisig","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Schlioma","family":"Zaterka","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulysses","family":"Meneghelli","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"27","article-title":"Reflux rising - a burning issue! 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