{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T16:28:08Z","timestamp":1746462488012},"reference-count":45,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:p>RACIONAL: A evolu\u00e7\u00e3o desfavor\u00e1vel de aproximadamente 1\/3 dos doentes com neoplasias catalogadas no est\u00e1dio B de Dukes, mostra ser desej\u00e1vel a adi\u00e7\u00e3o de outros crit\u00e9rios morfol\u00f3gicos progn\u00f3sticos. A diferencia\u00e7\u00e3o celular, a presen\u00e7a de muco e o padr\u00e3o de crescimento da margem invasiva foram pouco estudados em tumores Dukes B e os relatos da literatura s\u00e3o controversos. OBJETIVOS: Avaliar o valor progn\u00f3stico do grau de diferencia\u00e7\u00e3o celular, da presen\u00e7a de muco e do padr\u00e3o de crescimento da margem invasiva em doentes com adenocarcinomas colorretais classificados como Dukes B. M\u00c9TODO: Foram estudados retrospectivamente 156 doentes com adenocarcinomas colorretais submetidos a extirpa\u00e7\u00e3o curativa e cujos esp\u00e9cimes foram classificados como Dukes B. A idade mediana era de 58 anos, com 94 (60,26%) do sexo feminino e 62 (39,74%) do sexo masculino. A diferencia\u00e7\u00e3o celular foi classificada em dois graus: baixo e alto grau de malignidade, de acordo com a \u00e1rea de diferencia\u00e7\u00e3o predominante da neoplasia. Tumores com pelo menos 60% de seu volume em muco foram chamados de mucinosos. O crescimento da margem invasiva foi classificado como expansivo quando o tumor crescia de forma romba, empurrando as estruturas adjacentes e infiltrativo quando formava frentes digitiformes em v\u00e1rias dire\u00e7\u00f5es e profundidade. RESULTADOS: Constatou-se predom\u00ednio das neoplasias de baixa malignidade 139 (89,10%), n\u00e3o-mucinosas 142 (91,03%) e com margem do tipo infiltrativo 123 (78,85%). Somente o crescimento da margem invasiva influenciou a sobrevida de 5 anos. Doentes com neoplasias exibindo margem do tipo expansivo apresentaram sobrevida significativamente maior que aqueles com margem do tipo infiltrativo - 81,82% x 60,98%. CONCLUS\u00c3O: O tipo de crescimento da margem invasiva mostrou-se capaz de identificar sub-popula\u00e7\u00f5es de doentes de maior ou menor risco progn\u00f3stico.<\/jats:p>","DOI":"10.1590\/s0004-28032004000300009","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:21:35Z","timestamp":1113574895000},"page":"185-189","source":"Crossref","is-referenced-by-count":4,"title":["Valor progn\u00f3stico do grau de diferencia\u00e7\u00e3o celular, da presen\u00e7a de muco e do padr\u00e3o de crescimento da margem invasiva em adenocarcinomas colorretais Dukes B"],"prefix":"10.1590","volume":"41","author":[{"given":"Clodoaldo","family":"Henrique-Filho","sequence":"first","affiliation":[{"name":"Hospital do Servidor P\u00fablico Estadual Francisco Morato de Oliveira"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sansom Henrique","family":"Bromberg","sequence":"additional","affiliation":[{"name":"Hospital do Servidor P\u00fablico Estadual Francisco Morato de Oliveira"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elci","family":"Barreto","sequence":"additional","affiliation":[{"name":"Hospital do Servidor P\u00fablico Estadual Francisco Morato de Oliveira"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f4nio Claudio de","family":"Godoy","sequence":"additional","affiliation":[{"name":"Hospital do Servidor P\u00fablico Estadual Francisco Morato de Oliveira"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds Celso","family":"Mattosinho-Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Hospital do Servidor P\u00fablico Estadual Francisco Morato de Oliveira"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/jso.2930420404","article-title":"Histopathologic evaluation of survival time in patients with colorectal carcinoma","volume":"42","author":"Adachi Y","year":"1989","journal-title":"J Surg Oncol","ISSN":"http:\/\/id.crossref.org\/issn\/0022-4790","issn-type":"print"},{"key":"ref2","first-page":"237","article-title":"Factores pron\u00f3sticos en el c\u00e1ncer colorrectal: an\u00e1lisis multivariado de 224 pacientes","volume":"129","author":"Bannura-Cumsille G","year":"2001","journal-title":"Rev M\u00e9d Chile"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1136\/jcp.34.5.509","article-title":"Histopathology reporting in large bowel cancer","volume":"34","author":"Blenkinsopp WK","year":"1981","journal-title":"J Clin Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9746","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/S1072-7515(98)00018-0","article-title":"Stage I rectal cancer: identification of high-risk patients","volume":"186","author":"Blumberg D","year":"1998","journal-title":"J Am Coll Surg","ISSN":"http:\/\/id.crossref.org\/issn\/1072-7515","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/BF02055674","article-title":"Factors affecting survival after excision of the rectum for cancer: a multivariate analysis","volume":"40","author":"Bokey EL","year":"1997","journal-title":"Dis Colon Rectum","ISSN":"http:\/\/id.crossref.org\/issn\/0012-3706","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1590\/S0102-86501997000300013","article-title":"Estudo de fatores morfol\u00f3gicos progn\u00f3sticos do c\u00e2ncer colo-retal extirpado","volume":"12","author":"Bromberg SH","year":"1997","journal-title":"Acta Cir Bras"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF02553907","article-title":"Prognostic correlations of operable carcinoma of the rectum","volume":"28","author":"Carlon CA","year":"1985","journal-title":"Dis Colon Rectum","ISSN":"http:\/\/id.crossref.org\/issn\/0012-3706","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1007\/s10350-004-6683-1","article-title":"Favorable influence of age on tumor characteristics of sporadic colorectal adenocarcinoma: patients 30 years of age or younger may be a distinct patient group","volume":"46","author":"Chiang JM","year":"2003","journal-title":"Dis Colon Rectum","ISSN":"http:\/\/id.crossref.org\/issn\/0012-3706","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1007\/BF02055162","article-title":"Character of the invasive margin in colorectal cancer: does it improve prognostic information of Dukes staging?","volume":"40","author":"Cianchi F","year":"1997","journal-title":"Dis Colon Rectum","ISSN":"http:\/\/id.crossref.org\/issn\/0012-3706","issn-type":"print"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1245\/aso.2002.9.1.20","article-title":"Tumor angiogenesis in lymph node-negative rectal cancer: correlation with clinicopathological parameters and prognosis","volume":"9","author":"Cianchi F","year":"2002","journal-title":"Ann Surg Oncol","ISSN":"http:\/\/id.crossref.org\/issn\/1068-9265","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1002\/(SICI)1097-0142(20000401)88:7<1739::AID-CNCR30>3.0.CO;2-T","article-title":"American Joint Committee on Cancer Prognostic Factors Consensus Conference: Colorectal Working Group","volume":"88","author":"Compton C","year":"2000","journal-title":"Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"979","DOI":"10.5858\/2000-124-0979-PFICC","article-title":"Prognostic factors in colorectal cancer","volume":"124","author":"Compton CC","year":"2004","journal-title":"Arch Pathol Lab Med","ISSN":"http:\/\/id.crossref.org\/issn\/0003-9985","issn-type":"print"},{"key":"ref13","first-page":"1022","article-title":"Mucinous carcinomas of the colon and rectum","volume":"115","author":"Connelly JH","year":"1991","journal-title":"Arch Pathol Lab Med","ISSN":"http:\/\/id.crossref.org\/issn\/0003-9985","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1080\/110241599750006514","article-title":"Prognosis in Duke\u2019s B colorectal carcinoma: the Jass classification revisited","volume":"165","author":"De Quay N","year":"1999","journal-title":"Eur J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/1102-4151","issn-type":"print"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/path.1700350303","article-title":"The classification of cancer of the rectum","volume":"35","author":"Dukes CE","year":"1932","journal-title":"J Pathol Bacteriol","ISSN":"http:\/\/id.crossref.org\/issn\/0368-3494","issn-type":"print"},{"key":"ref16","series-title":"Histochemistry in pathology","first-page":"126","volume-title":"Malignant and inflammatory diseases of the gastrointestinal tract","author":"Filipe MI","year":"1983"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/BF02234734","article-title":"Dukes B colorectal cancer: distint genetic categories and clinical outcome based on proximal or distal tumor location","volume":"44","author":"Gervaz P","year":"2001","journal-title":"Dis Colon Rectum","ISSN":"http:\/\/id.crossref.org\/issn\/0012-3706","issn-type":"print"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF02050301","article-title":"Mucinous carcinoma - just another colon cancer?","volume":"36","author":"Green JB","year":"1993","journal-title":"Dis Colon Rectum","ISSN":"http:\/\/id.crossref.org\/issn\/0012-3706","issn-type":"print"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1097\/00000658-193904000-00002","article-title":"The grading and prognosis of carcinoma of the colon and rectum","volume":"109","author":"Grinnel RS","year":"1939","journal-title":"Ann Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0003-4932","issn-type":"print"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1136\/jcp.41.5.532","article-title":"Degree of differentiation in colorectal adenocarcinomas: a multivariate analysis of the influence on survival","volume":"41","author":"Halvorsen TB","year":"1988","journal-title":"J Clin Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9746","issn-type":"print"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1136\/jcp.41.10.1068","article-title":"Influence of mucinous components on survival in colorectal adenocarcinomas: a multivariate analysis","volume":"41","author":"Halvorsen TB","year":"1988","journal-title":"J Clin Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9746","issn-type":"print"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1136\/jcp.42.2.162","article-title":"Association between invasiveness, inflammatory reaction, desmoplasia and survival in colorectal cancer","volume":"42","author":"Halvorsen TB","year":"1989","journal-title":"J Clin Pathol","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9746","issn-type":"print"},{"key":"ref23","first-page":"905","article-title":"Histopathological studies on the prognosis of the rectal carcinoma, especially on the comparison with that of the gastric carcinoma","volume":"21","author":"Isono K","year":"1975","journal-title":"Gan No Rinsho","ISSN":"http:\/\/id.crossref.org\/issn\/0021-4949","issn-type":"print"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2559.1986.tb02497.x","article-title":"The grading of rectal cancer: historical perspectives and a multivariate analysis of 447 cases","volume":"10","author":"Jass JR","year":"1986","journal-title":"Histopathology","ISSN":"http:\/\/id.crossref.org\/issn\/0309-0167","issn-type":"print"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/S0022-3468(99)90112-4","article-title":"Colorectal carcinoma in children","volume":"34","author":"Karnak I","year":"1999","journal-title":"J Pediatr Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0022-3468","issn-type":"print"},{"key":"ref26","series-title":"Statistical methods for survival data analysis","first-page":"551","author":"Lee ET","year":"1980"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00000658-198809000-00016","article-title":"A 5- to 21- years follow-up and analysis of 250 patients with rectal adenocarcinoma","volume":"208","author":"Michelassi F","year":"1988","journal-title":"Ann Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0003-4932","issn-type":"print"},{"key":"ref28","first-page":"456","article-title":"Prognostic factors in colorectal adenocarcinoma of Dukes stage B.: Study of a series of population","volume":"18","author":"Michiels C","year":"1994","journal-title":"Gastroenterol Clin Biol","ISSN":"http:\/\/id.crossref.org\/issn\/0399-8320","issn-type":"print"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1053\/ejso.2000.1094","article-title":"Mucinous differentiation in colonic adenocarcinoma is associated with a reduction in tumor-infiltrating lymphocytes","volume":"27","author":"Millar EKA","year":"2001","journal-title":"Eur J Surg Oncol","ISSN":"http:\/\/id.crossref.org\/issn\/0748-7983","issn-type":"print"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1002\/1097-0142(197706)39:6<2475::AID-CNCR2820390626>3.0.CO;2-L","article-title":"Gastric carcinoma: A pathobiological classification","volume":"39","author":"Ming SC","year":"1977","journal-title":"Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1002\/1097-0142(19871215)60:12<3103::AID-CNCR2820601241>3.0.CO;2-6","article-title":"Colloid carcinoma of the colon and rectum","volume":"60","author":"Minsky BD","year":"1987","journal-title":"Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/BF02050424","article-title":"Identifying stage B colorectal cancer patients at high risk of tumor recurrence and death","volume":"40","author":"Mulcahy HE","year":"1997","journal-title":"Dis Colon Rectum","ISSN":"http:\/\/id.crossref.org\/issn\/0012-3706","issn-type":"print"},{"key":"ref33","first-page":"681","article-title":"Mucinous colorectal carcinoma: clinical pathology and prognosis","volume":"54","author":"Okuno M","year":"1988","journal-title":"Am Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0003-1348","issn-type":"print"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1002\/bjs.1800710813","article-title":"Large bowel cancer: surgical pathology and its relationship to survival","volume":"71","author":"Phillips RK","year":"1984","journal-title":"Br J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1323","issn-type":"print"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-2559.2000.00826.x","article-title":"Histopathological grade, mucinous differentiation and DNA ploidy in relation to prognosis in colorectal carcinoma","volume":"36","author":"Purdie CA","year":"2000","journal-title":"Histopathology","ISSN":"http:\/\/id.crossref.org\/issn\/0309-0167","issn-type":"print"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1177\/003591576505801014","article-title":"The pathology and prognosis of carcinoma of the rectum in the young","volume":"58","author":"Recio P","year":"1965","journal-title":"Proc R Soc Med","ISSN":"http:\/\/id.crossref.org\/issn\/0035-9157","issn-type":"print"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/1097-0142(19831001)52:7<1317::AID-CNCR2820520731>3.0.CO;2-6","article-title":"Patterns of recurrence of rectal cancer after potentially curative surgery","volume":"52","author":"Rich T","year":"1983","journal-title":"Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"ref38","series-title":"Manual de padroniza\u00e7\u00e3o de laudos histopatol\u00f3gicos","first-page":"83","volume-title":"Carcinomas do colon e do reto","author":"Rodrigues MAM","year":"1999","edition":"2"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1365-2559.1987.tb02631.x","article-title":"Mucinous carcinoma of the rectum","volume":"11","author":"Sasaki O","year":"1987","journal-title":"Histopathology","ISSN":"http:\/\/id.crossref.org\/issn\/0309-0167","issn-type":"print"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1002\/1097-0142(197604)37:4<1891::AID-CNCR2820370439>3.0.CO;2-Z","article-title":"Mucinous carcinoma of the colon and rectum","volume":"37","author":"Symonds DA","year":"1976","journal-title":"Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1365-2559.1981.tb01774.x","article-title":"Invasion of veins by carcinoma of rectum: method of detection, histological features and significance","volume":"5","author":"Talbot IC","year":"1981","journal-title":"Histopathology","ISSN":"http:\/\/id.crossref.org\/issn\/0309-0167","issn-type":"print"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1159\/000227235","article-title":"The clinical significance of the histologic subclassification of colorectal carcinoma","volume":"50","author":"Teixeira CR","year":"1993","journal-title":"Oncology","ISSN":"http:\/\/id.crossref.org\/issn\/0030-2414","issn-type":"print"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/1097-0142(195105)4:3<597::AID-CNCR2820040311>3.0.CO;2-3","article-title":"Mucoid carcinoma of the rectum","volume":"4","author":"Trimpi HD","year":"1951","journal-title":"Cancer","ISSN":"http:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1046\/j.1365-2559.2002.01376.x","article-title":"Clinicopathological significance of the \"keloid-like\" collagen and myxoid stroma in advanced rectal cancer","volume":"40","author":"Ueno H","year":"2002","journal-title":"Histophatology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/bjs.1800720915","article-title":"Peculiarities of mucinous colorectal carcinoma","volume":"72","author":"Umpleby HC","year":"1985","journal-title":"Br J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1323","issn-type":"print"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ag\/v41n3\/a09v41n3.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T21:05:11Z","timestamp":1625778311000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032004000300009&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0004-28032004000300009"],"URL":"https:\/\/doi.org\/10.1590\/s0004-28032004000300009","relation":{},"ISSN":["0004-2803"],"issn-type":[{"value":"0004-2803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}