{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T09:17:00Z","timestamp":1793870220399,"version":"4.6.1"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2004,12]]},"abstract":"<jats:p>RACIONAL: Les\u00f5es peritoniais, comuns no per e p\u00f3s-operat\u00f3rio, levam \u00e0 forma\u00e7\u00e3o de ader\u00eancias, cuja incid\u00eancia aumenta ainda mais com o uso de telas de polipropileno. A nitrofurazona \u00e9 uma subst\u00e2ncia que acelera o processo de cicatriza\u00e7\u00e3o e, devido a isso, cogitou-se a possibilidade de uma a\u00e7\u00e3o sobre as ader\u00eancias peritoniais. OBJETIVO: Avaliar as ader\u00eancias p\u00f3s-operat\u00f3rias em ratos submetidos a peritoniostomia com fixa\u00e7\u00e3o de tela de polipropileno associada a nitrofurazona. MATERIAL E M\u00c9TODOS: Utilizaram-se 33 ratos Wistar, divididos em 3 grupos de 11 animais, sendo no grupo I realizado laparotomia com exposi\u00e7\u00e3o da cavidade ao ar ambiente e posterior laparorrafia; no grupo II, ressec\u00e7\u00e3o de fragmento da parede abdominal com fixa\u00e7\u00e3o de tela de polipropileno no espa\u00e7o e no grupo III, procedimento semelhante ao do grupo II, por\u00e9m com tela embebida em nitrofurazona. Ap\u00f3s 45 dias foram sacrificados e necropsiados. RESULTADOS: Dos animais do grupo I, sete n\u00e3o tiveram ader\u00eancias (grau 0), dois tiveram ader\u00eancias de grau 1 e dois de grau 2. No grupo II, 1 foi classificado como grau 3 e 10 como grau 4. No grupo III, um foi de grau 0, oito de grau 3 e um de grau 4 (um animal foi a \u00f3bito antes de 45 dias). Todas as ader\u00eancias encontradas envolveram parede abdominal; 10 animais tiveram ader\u00eancias envolvendo apenas o omento (grupo I = 4; grupo II = 1 e grupo III = 5); 11 animais tiveram ader\u00eancias envolvendo o omento, as al\u00e7as intestinais e outros \u00f3rg\u00e3os abdominais, sendo 10 do grupo II e um do grupo III; tr\u00eas animais tiveram ader\u00eancias envolvendo apenas al\u00e7as intestinais, sendo todos do grupo III. Dos 14 animais que tiveram ader\u00eancias envolvendo as al\u00e7as intestinais, 10 eram do grupo II (9 com mais de um ponto) e 4 do grupo III (3 com somente um ponto de fixa\u00e7\u00e3o). CONCLUS\u00c3O: O uso de nitrofurazona associado \u00e0 tela de polipropileno n\u00e3o reduziu significativamente a incid\u00eancia de ader\u00eancias p\u00f3s-operat\u00f3rias em ratos, por\u00e9m diminuiu a intensidade e gravidade dessas ader\u00eancias.<\/jats:p>","DOI":"10.1590\/s0004-28032004000400009","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:21:51Z","timestamp":1113574911000},"page":"245-249","source":"Crossref","is-referenced-by-count":11,"title":["Avalia\u00e7\u00e3o das ader\u00eancias p\u00f3s-operat\u00f3rias em ratos submetidos a peritoniostomia com tela de polipropileno associada \u00e0 nitrofurazona"],"prefix":"10.1590","volume":"41","author":[{"given":"Augusto","family":"Diogo-Filho","sequence":"first","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Cunha Mello","family":"Lazarini","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floriano","family":"Vieira-Junyor","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele Juliana","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heitor Luiz","family":"Gomes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1590\/S0034-89101999000500014","article-title":"Dioxinas e furanos: origens e riscos","volume":"33","author":"Assun\u00e7\u00e3o JV","year":"1999","journal-title":"Rev 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