{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T08:53:46Z","timestamp":1648716826344},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p>RACIONAL: Dados da literatura sugerem que, possivelmente, a lavagem intraluminar de segmentos do tubo digestivo com povidona-iodine antes da execu\u00e7\u00e3o de uma anastomose poderia favorecer a cicatriza\u00e7\u00e3o dessas anastomoses e prevenir a forma\u00e7\u00e3o de ader\u00eancias perianastom\u00f3ticas, podendo ser \u00fatil se empregada em pacientes submetidos cirurgias do trato digestivo. OBJETIVO: Avaliar a efic\u00e1cia da lavagem das bordas ent\u00e9ricas com povidona-iodine a 5% sobre a cicatriza\u00e7\u00e3o do c\u00f3lon direito de ratos. MATERIAL E M\u00c9TODOS: Estudaram-se 20 ratos Wistar divididos nos seguintes grupos: A (n = 10), limpeza das bordas da ferida col\u00f4nica com solu\u00e7\u00e3o salina a 0,9%; B (n = 10), limpeza das bordas da ferida col\u00f4nica com solu\u00e7\u00e3o de povidona-iodine a 5%. Os animais foram submetidos a laparotomia, sec\u00e7\u00e3o de 75% da circunfer\u00eancia do c\u00f3lon, preservando 25% da borda mesent\u00e9rica e tratamento das bordas a serem anastomosadas segundo o grupo descrito acima. Ap\u00f3s a realiza\u00e7\u00e3o das anastomoses, os animais foram observados durante 7 dias e, no 7\u00ba dia p\u00f3s-operat\u00f3rio, mortos. Foram coletadas amostras de sangue para dosagem da albumina s\u00e9rica e feita an\u00e1lise macrosc\u00f3pica das anastomoses, observando-se presen\u00e7a de f\u00edstula, ader\u00eancias e dilata\u00e7\u00e3o acima da anastomose. O segmento contendo a anastomose col\u00f4nica foi retirado com 3 cm de c\u00f3lon intacto em torno da anastomose e feita medida da press\u00e3o de ruptura. RESULTADOS: N\u00e3o se observou presen\u00e7a de f\u00edstula em nenhum animal dos grupos estudados. N\u00e3o houve diferen\u00e7a significativa em rela\u00e7\u00e3o \u00e0 presen\u00e7a de estenose da anastomose, ader\u00eancias ou no valor da press\u00e3o de ruptura quando comparados os dois grupos. CONCLUS\u00c3O: O emprego da povidona-iodine n\u00e3o resultou em aumento da resist\u00eancia t\u00eansil das anastomoses do c\u00f3lon direito de ratos.<\/jats:p>","DOI":"10.1590\/s0004-28032005000200006","type":"journal-article","created":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T18:33:47Z","timestamp":1136831627000},"page":"95-98","source":"Crossref","is-referenced-by-count":4,"title":["Efeito do uso de povidine-iodine na cicatriza\u00e7\u00e3o de anastomoses de c\u00f3lon direito de ratos"],"prefix":"10.1590","volume":"42","author":[{"given":"Leandro Cruz","family":"Milagres","sequence":"first","affiliation":[{"name":"Universidade Federal de Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivana Duval","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumara Marques","family":"Barral","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni C\u00e9sar Xavier","family":"Grossi","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"61","article-title":"Influ\u00eancia do preparo per-operat\u00f3rio do c\u00f3lon com polivinilpirrolidona-iodo na cicatriza\u00e7\u00e3o da anastomose prim\u00e1ria do c\u00f3lon esquerdo obstru\u00eddo: estudo em ratos","volume":"11","author":"Aguilar-Nascimento JE","year":"1991","journal-title":"Rev Bras Coloproctol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/bjs.1800820410","article-title":"Enhanced intra-anastomotic healing by operative lavage with nutrient solutions in experimental left-sided colonic obstrution","volume":"82","author":"Aguilar-Nascimento JE","year":"1995","journal-title":"Br J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1323","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1001\/archsurg.1979.01370260044006","article-title":"Bacteriologic and systemic effects of intraoperative segmental bowel preparation with povidine iodine","volume":"114","author":"Arango A","year":"1979","journal-title":"Arch Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0004-0010","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.1365-2168.1999.01011.x","article-title":"Local and systemic effects of intraopertive whole-colon washout with 5 per cent povidine-iodine","volume":"86","author":"Basha G","year":"1999","journal-title":"Br J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1323","issn-type":"print"},{"key":"ref5","first-page":"43","article-title":"Iodine absorption after topical administration","volume":"146","author":"Cruz FD","year":"1987","journal-title":"West J Med","ISSN":"http:\/\/id.crossref.org\/issn\/0093-0415","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/bjs.1800820816","article-title":"Efficacy of tumoricidal agents in vitro and in vivo","volume":"82","author":"Docherty JG","year":"1995","journal-title":"Br Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/bjs.1800670203","article-title":"Intraoperative irrigation of the colon to permit primary anastomosis","volume":"67","author":"Dudley HAF","year":"1980","journal-title":"Br J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1323","issn-type":"print"},{"key":"ref8","first-page":"228","article-title":"Single-dose ceftriaxone, ornidazole and povidine-iodine enema in elective left colectomy.: A randomized multicenter controlled trial","volume":"128","author":"Fingerhut A","year":"1993","journal-title":"The French Association for Surgical Research. 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