{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T18:33:45Z","timestamp":1777055625931,"version":"3.51.4"},"reference-count":31,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p>RACIONAL: O tratamento convencional de Helicobacter pylori consiste na utiliza\u00e7\u00e3o de antimicrobianos, aos quais uma minoria expressiva de pacientes n\u00e3o responde. Tratamentos alternativos para a infec\u00e7\u00e3o t\u00eam sido propostos, incluindo o uso de antioxidantes. Destaque crescente tem sido atribu\u00eddo \u00e0 vitamina C ao se demonstrar que concentra\u00e7\u00f5es da mesma no est\u00f4mago de indiv\u00edduos infectados com H. pylori s\u00e3o substancialmente menores do que as de indiv\u00edduos saud\u00e1veis. Doses farmacol\u00f3gicas de vitamina C foram investigadas na erradica\u00e7\u00e3o de H. pylori com resultados controversos. OBJETIVO: Avaliar o efeito da administra\u00e7\u00e3o via oral de vitamina C sobre a coloniza\u00e7\u00e3o de est\u00f4mago por H. pylori em pacientes infectados, com gastrite cr\u00f4nica ou com \u00falcera p\u00e9ptica cujos tratamentos convencionais n\u00e3o resultaram em erradica\u00e7\u00e3o. MATERIAL E M\u00c9TODOS: Protocolo I: estudo aleat\u00f3rio, duplo-cego, controlado por placebo em pacientes com gastrite cr\u00f4nica, sem tratamento pr\u00e9vio para a infec\u00e7\u00e3o. Protocolo II: estudo aberto, n\u00e3o controlado em pacientes com \u00falcera p\u00e9ptica e pelo menos dois tratamentos pr\u00e9vios de erradica\u00e7\u00e3o. O tratamento consistiu em vitamina C 5 g\/dia durante 28 dias consecutivos. Seu efeito foi avaliado pelo teste respirat\u00f3rio com 14C-ur\u00e9ia quanto \u00e0 taxa de erradica\u00e7\u00e3o, \u00e0 varia\u00e7\u00e3o de radioatividade e \u00e0 supress\u00e3o da infec\u00e7\u00e3o. RESULTADOS: No protocolo I, 38 pacientes completaram o estudo, 21 recebendo vitamina C e 17 recebendo placebo durante 28 dias. A taxa de erradica\u00e7\u00e3o \"por protocolo\" com vitamina C foi zero, intervalo de confian\u00e7a de 95%: 0%-15%. No protocolo II, oito pacientes completaram o tratamento. A taxa de erradica\u00e7\u00e3o foi zero, com intervalo de confian\u00e7a de 95%: 05-32%. N\u00e3o houve diminui\u00e7\u00e3o da carga bacteriana. CONCLUS\u00d5ES: A administra\u00e7\u00e3o de vitamina C na dosagem di\u00e1ria de 5 g durante 28 dias n\u00e3o \u00e9 eficaz na erradica\u00e7\u00e3o de infec\u00e7\u00e3o por H. pylori, nem altera quantitativamente sua carga no est\u00f4mago dos pacientes infectados.<\/jats:p>","DOI":"10.1590\/s0004-28032005000300008","type":"journal-article","created":{"date-parts":[[2006,1,9]],"date-time":"2006-01-09T18:09:12Z","timestamp":1136830152000},"page":"167-172","source":"Crossref","is-referenced-by-count":13,"title":["Efeito da administra\u00e7\u00e3o de vitamina C sobre a coloniza\u00e7\u00e3o do est\u00f4mago por Helicobacter pylori"],"prefix":"10.1590","volume":"42","author":[{"given":"Mayra Mayumi","family":"Kamiji","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Brandt de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1046\/j.1365-2362.1998.00349.x","article-title":"Relative hyperoxaluria, crystalluria and haematuria after megadose ingestion of vitamin C","volume":"28","author":"Auer BL","year":"1998","journal-title":"Eur J Clin Invest","ISSN":"https:\/\/id.crossref.org\/issn\/0014-2972","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1136\/gut.35.3.317","article-title":"Effect of Helicobacter pylori and its eradication on gastric juice ascorbic acid","volume":"35","author":"Banerjee S","year":"1994","journal-title":"Gut","ISSN":"https:\/\/id.crossref.org\/issn\/0017-5749","issn-type":"print"},{"issue":"Suppl","key":"ref3","first-page":"143s","article-title":"Non-antibiotic therapies for infectious diseases","volume":"27","author":"Carson CF","year":"2003","journal-title":"Commun Dis Intell","ISSN":"https:\/\/id.crossref.org\/issn\/0725-3141","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1093\/clinchem\/31.10.1703","article-title":"Stability of ascorbate in urine: relevance to analyses for ascorbate and oxalate","volume":"31","author":"Chalmers AH","year":"1985","journal-title":"Clin Chem","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9147","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/jnci\/92.23.1881","article-title":"Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-Helicobacter pylori therapy","volume":"92","author":"Correa P","year":"2000","journal-title":"J Natl Cancer Inst","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8874","issn-type":"print"},{"key":"ref6","first-page":"85","article-title":"Helicobacter pylori infection, a paradigm for chronic mucosal inflammation: pathogenesis and implications for erradication and prevention","volume":"41","author":"Cover TL","year":"1996","journal-title":"Adv Intern Med","ISSN":"https:\/\/id.crossref.org\/issn\/0065-2822","issn-type":"print"},{"key":"ref7","first-page":"96","article-title":"Vitamin C concentration in gastric juice in patients with precancerous lesions of the stomach and gastric cancer","volume":"8","author":"Dabrowska-Ufniarz E","year":"2002","journal-title":"Med Sci Monit"},{"key":"ref8","series-title":"Dietary reference intakes for vitamin C, vitamin E, selenium, and carotenoids: a report of the Panel on Dietary Antioxidants and Related Compounds, Subcommittees on Upper Reference Levels of Nutrients and Interpretation and Uses of Dietary Reference Intakes, and the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. 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