{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T13:20:31Z","timestamp":1768742431878,"version":"3.49.0"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p>RACIONAL: A s\u00edndrome hepatopulmonar \u00e9 caracterizada por uma disfun\u00e7\u00e3o hep\u00e1tica e pela exist\u00eancia de dilata\u00e7\u00f5es dos vasos pulmonares, levando a altera\u00e7\u00f5es nas trocas gasosas, tendo algumas das suas caracter\u00edsticas observadas de forma experimental no modelo de ligadura de ducto biliar. OBJETIVOS: Avaliar o estresse oxidativo no tecido pulmonar de ratos cirr\u00f3ticos por ligadura de ducto biliar comum. MATERIAIS E M\u00c9TODOS: Foram utilizados 12 ratos machos Wistar, pesando entre 200 e 300 g, divididos em dois grupos: controles (Co = 6) e cirr\u00f3ticos (Ci = 6). Foram realizadas avalia\u00e7\u00f5es de transaminases, gasometria arterial, avalia\u00e7\u00e3o da lipoperoxida\u00e7\u00e3o (subst\u00e2ncias reativas ao \u00e1cido tiobarbit\u00farico e quimiluminesc\u00eancia) e quantifica\u00e7\u00e3o da atividade enzim\u00e1tica antioxidante atrav\u00e9s das concentra\u00e7\u00f5es da enzima super\u00f3xido dismutase. Os tecidos analisados para avalia\u00e7\u00e3o da s\u00edndrome hepatopulmonar foram o f\u00edgado cirr\u00f3tico e o pulm\u00e3o. RESULTADOS: Os animais com ligadura de ducto biliar apresentaram altera\u00e7\u00e3o nas transaminases: aspartato aminotransferase, Co = 105,3 \u00b1 43\/Ci = 500,5 \u00b1 90,3 alanina aminotransferase, Co = 78,75 \u00b1 37,7\/Ci = 162,75 \u00b1 35,4 e fosfatase alcalina, Co = 160 \u00b1 20,45\/Ci = 373,25 \u00b1 45,44. Em rela\u00e7\u00e3o \u00e0 lipoperoxida\u00e7\u00e3o e \u00e0 resposta antioxidante, estas tamb\u00e9m apresentaram diferen\u00e7as estatisticamente significativas quando avaliadas no pulm\u00e3o (subst\u00e2ncias reativas ao \u00e1cido tiobarbit\u00farico) Co = 0,87 \u00b1 0,3\/Ci = 2,01 \u00b1 0,9; quimiluminesc\u00eancia Co = 16008,41 \u00b1 1171,45\/Ci = 20250,36 \u00b1 827,82; super\u00f3xido dismutase Co = 6,66 \u00b1 1,34\/Ci = 16,06 \u00b1 2,67. CONCLUS\u00d5ES: Os dados obtidos sugerem que no modelo experimental de cirrose por ligadura de ducto biliar h\u00e1 aumento significativo da lipoperoxida\u00e7\u00e3o no tecido pulmonar, bem como aumento na atividade da enzima antioxidante super\u00f3xido dismutase, sugerindo a presen\u00e7a de dano pulmonar decorrente da cirrose biliar secund\u00e1ria.<\/jats:p>","DOI":"10.1590\/s0004-28032005000400010","type":"journal-article","created":{"date-parts":[[2006,2,10]],"date-time":"2006-02-10T14:05:59Z","timestamp":1139580359000},"page":"244-248","source":"Crossref","is-referenced-by-count":12,"title":["Ligadura de ducto biliar como modelo de estudo da s\u00edndrome hepatopulmonar e estresse oxidativo"],"prefix":"10.1590","volume":"42","author":[{"given":"Juliana","family":"Tieppo","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Vercelino","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Sim\u00f5es","family":"Dias","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul; Centro Universit\u00e1rio-IPA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udio Augusto","family":"Marroni","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Faculdade Federal de Ci\u00eancias M\u00e9dicas de Porto Alegre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma","family":"Marroni","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul; Universidade Luterana do 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ABM","year":"2001","edition":"2"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microssomal lipid peroxidation","volume":"52","author":"Buege JA","year":"1978","journal-title":"Meth Enzimol"},{"key":"ref5","first-page":"1","article-title":"The lung in liver disease","volume":"17","author":"Chang SW","year":"1996","journal-title":"Clin Chest Med","ISSN":"https:\/\/id.crossref.org\/issn\/0272-5231","issn-type":"print"},{"key":"ref6","series-title":"Modelos experimentais de pesquisa em cirurgia","volume-title":"Altera\u00e7\u00f5es imunol\u00f3gicas na obstru\u00e7\u00e3o biliar extra-hep\u00e1tica","author":"Cruz CAT","year":"1998"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3109\/00365526809180140","article-title":"Arteriovenous shunts in cirrhotic patients studied with human serum albumin macroagragates tagged with I-131 (MAA131-I)","volume":"3","author":"Dal Palu C","year":"1968","journal-title":"Scand J Gastroenterol","ISSN":"https:\/\/id.crossref.org\/issn\/0036-5521","issn-type":"print"},{"key":"ref8","first-page":"53","article-title":"S\u00edndrome hepatopulmonar: fisiopatogenia e op\u00e7\u00f5es terap\u00eauticas","volume":"17","author":"Garcia E","year":"1998","journal-title":"GED Gastroenterol Endosc Dig"},{"key":"ref9","first-page":"279","article-title":"S\u00edndrome hepatopulmonar","volume":"22","author":"Garcia E","year":"1996","journal-title":"J Pneumol","ISSN":"https:\/\/id.crossref.org\/issn\/0102-3586","issn-type":"print"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1053\/gast.1997.v113.pm9247483","article-title":"The role of endothelial nitric oxide synthase in the pathogenesis of a rat model of hepatopulmonary syndrome","volume":"113","author":"Fallon 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Med"},{"key":"ref15","first-page":"305","article-title":"Prolonged bile duct obstruction: a new experimental model for cirrhoses in the rat","volume":"65","author":"Kountouras J","year":"1984","journal-title":"Br J Exp Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0007-1021","issn-type":"print"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0168-8278(98)80152-9","article-title":"Endothelin-1 int the rat bile duct ligation model of hepatopulmonary syndrome: correlation with pulmonary dysfunction","volume":"29","author":"Luo B","year":"1998","journal-title":"J Hepatol","ISSN":"https:\/\/id.crossref.org\/issn\/0168-8278","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1590\/S0102-86502003000300011","article-title":"Uso da quercetina a longo prazo em ratos cirr\u00f3ticos","volume":"18","author":"Miltersteiner A","year":"2003","journal-title":"Acta Cir 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OC","year":"1998"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"L1005","DOI":"10.1152\/ajplung.2000.279.6.L1005","article-title":"Reactive oxygen species in cell signaling","volume":"279","author":"Thannickal VJ","year":"2000","journal-title":"Am J Physiol Lung Cell Mol Physiol"}],"container-title":["Arquivos de 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