{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T14:55:54Z","timestamp":1773672954923,"version":"3.50.1"},"reference-count":45,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:p>RACIONAL: A infec\u00e7\u00e3o pelo Helicobacter pylori \u00e9 fator importante no desenvolvimento da carcinog\u00eanese g\u00e1strica, mas somente uma fra\u00e7\u00e3o dos pacientes infectados ir\u00e1 desenvolver c\u00e2ncer g\u00e1strico. A infec\u00e7\u00e3o pelo H. pylori determina gastrite cr\u00f4nica n\u00e3o-atr\u00f3fica, que pode evoluir para gastrite atr\u00f3fica e metaplasia intestinal e, finalmente, para displasia e adenocarcinoma. OBJETIVO: Estudar a preval\u00eancia da infec\u00e7\u00e3o pelo H. pylori e das les\u00f5es precursoras de c\u00e2ncer g\u00e1strico e sua associa\u00e7\u00e3o, em pacientes submetidos a endoscopia digestiva alta em servi\u00e7o de refer\u00eancia da regi\u00e3o central do Estado do Rio Grande do Sul. M\u00caTODOS: Foram analisadas retrospectivamente biopsias de corpo e antro g\u00e1strico obtidas de pacientes submetidos a endoscopia digestiva alta no per\u00edodo entre 1994 e 2003, nas quais foi realizada pesquisa de H. pylori. As l\u00e2minas foram coradas pelo m\u00e9todo da hematoxilina-eosina e os achados histol\u00f3gicos foram classificados de acordo com o sistema de Sydney em mucosa normal, gastrite cr\u00f4nica n\u00e3o-atr\u00f3fica, gastrite atr\u00f3fica e metaplasia intestinal. As altera\u00e7\u00f5es histol\u00f3gicas encontradas foram relacionadas com a presen\u00e7a de infec\u00e7\u00e3o pelo H. pylori. RESULTADOS: Biopsias de 2.019 pacientes foram inclu\u00eddas no estudo. A idade m\u00e9dia dos pacientes foi de 52 (\u00b115) anos e 59% eram do sexo feminino. A pesquisa de H. pylori foi positiva em 76% dos pacientes. Mucosa normal, gastrite cr\u00f4nica n\u00e3o-atr\u00f3fica, gastrite atr\u00f3fica e metaplasia intestinal foram diagnosticadas em 5%, 77%, 3% e 15% das biopsias, respectivamente. A infec\u00e7\u00e3o por H. pylori determinou uma raz\u00e3o de chances 10 vezes (IC95% 6.50 - 17%) maior de se encontrar algum grau de altera\u00e7\u00e3o histol\u00f3gica na mucosa g\u00e1strica. A raz\u00e3o de chances dos pacientes infectados apresentarem gastrite cr\u00f4nica n\u00e3o-atr\u00f3fica, foi igual a 3 (IC95% 2,2 - 3,4). A raz\u00e3o de chances dos pacientes infectados apresentarem gastrite atr\u00f3fica e metaplasia intestinal foi menor que 1. CONCLUS\u00c3O: A preval\u00eancia da infec\u00e7\u00e3o por H. pylori foi alta (76%) e os indiv\u00edduos infectados apresentaram probabilidade 10 vezes maior para a ocorr\u00eancia de les\u00e3o da mucosa g\u00e1strica. Gastrite cr\u00f4nica n\u00e3o-atr\u00f3fica apresentou preval\u00eancia de 77%, gastrite atr\u00f3fica 3% e metaplasia intestinal 15%. A infec\u00e7\u00e3o pelo H. pylori determinou uma probabilidade 3 vezes maior para o desenvolvimento de gastrite cr\u00f4nica n\u00e3o-atr\u00f3fica e n\u00e3o determinou risco para a ocorr\u00eancia de gastrite atr\u00f3fica e metaplasia intestinal, sugerindo que possivelmente outros fatores de risco, al\u00e9m do H. pylori, estejam envolvidos no processo da carcinog\u00eanese g\u00e1strica.<\/jats:p>","DOI":"10.1590\/s0004-28032007000200002","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T19:42:48Z","timestamp":1490816568000},"page":"93-98","source":"Crossref","is-referenced-by-count":10,"title":["Preval\u00eancia da infec\u00e7\u00e3o por Helicobacter pylori e das les\u00f5es precusoras do c\u00e2ncer g\u00e1strico em pacientes disp\u00e9ticos"],"prefix":"10.1590","volume":"44","author":[{"given":"Leandro Bizarro","family":"Muller","sequence":"first","affiliation":[{"name":"Universidade Federal de Santa Maria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato Borges","family":"Fagundes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria; Universidade Federal do Rio Grande do Sul"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Carvalho de","family":"Moraes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Rampazzo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Maria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"368","article-title":"Non-cardia gastric adenocarcinoma and Helicobacter pylori infection","volume":"25","author":"Archimandritis A","year":"1993","journal-title":"Ital J Gastroenterol."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/(SICI)1097-0142(20000115)88:2<274::AID-CNCR5>3.0.CO;2-9","article-title":"Individual and joint contribution of family history and Helicobacter pylori infection to the risk of gastric carcinoma","volume":"88","author":"Brenner H","year":"2000","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1136\/gut.30.6.790","article-title":"Campylobacter pylori, duodenal ulcer and gastric metaplasia: possible role of functional heterotopic tissue in ulcerogenesis","volume":"30","author":"Carrick J","year":"1989","journal-title":"Gut","ISSN":"https:\/\/id.crossref.org\/issn\/0017-5749","issn-type":"print"},{"key":"ref4","first-page":"163","article-title":"Diagnosis and distribution of Helicobacter pylori: in the gastric mucosa of symptomatic children","volume":"24","author":"Carvalho AST","year":"1991","journal-title":"Braz J Med Biol Res","ISSN":"https:\/\/id.crossref.org\/issn\/0100-879X","issn-type":"print"},{"key":"ref5","first-page":"5","article-title":"Campylobacter pyloridis in the upper gastrointestinal tract: a Brazilian study","volume":"24","author":"Coelho LG","year":"1987","journal-title":"Arq Gastroenterol."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/BF01536269","article-title":"Campylobacter pylori in esophagus, antrum and duodenum: A histological and microbiological study","volume":"34","author":"Coelho LG","year":"1989","journal-title":"Dig Dis Sci","ISSN":"https:\/\/id.crossref.org\/issn\/0163-2116","issn-type":"print"},{"key":"ref7","first-page":"6735","article-title":"Human gastric carcinogenesis: a multistep and multifactorial process - First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention","volume":"52","author":"Correa P","year":"1992","journal-title":"Cancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"ref8","first-page":"s37","article-title":"Helicobacter pylori and gastric carcinogenesis","volume":"19","author":"Correa P","year":"1995","journal-title":"Am J Surg Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0147-5185","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1093\/jnci\/92.23.1881","article-title":"Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti-Helicobacter pylori therapy","volume":"92","author":"Correa P","year":"2000","journal-title":"J Natl Cancer Inst","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8874","issn-type":"print"},{"key":"ref10","first-page":"301","article-title":"The biological model of gastric carcinogenesis","volume":"157","author":"Correa P","year":"2004","journal-title":"IARC Sci Publ","ISSN":"https:\/\/id.crossref.org\/issn\/0300-5038","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1046\/j.1443-1661.2000.0048a.x","article-title":"Helicobacter pylori and precancerous gastric lesions","volume":"12","author":"Cu PQ","year":"2000","journal-title":"Dig Endosc"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/00008469-199309000-00003","article-title":"Anti-Helicobacter pylori antibodies prevalence and gastric adenocarcinoma in Portugal: report of a case-control study","volume":"2","author":"Estevens J","year":"1993","journal-title":"Eur J Cancer Prevent"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/0140-6736(93)90938-D","article-title":"An international association between Helicobacter pylori infection and gastric cancer","volume":"341","year":"1993","journal-title":"Lancet."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1136\/bmj.302.6788.1302","article-title":"Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation","volume":"302","author":"Forman D","year":"1991","journal-title":"BMJ","ISSN":"https:\/\/id.crossref.org\/issn\/0959-8138","issn-type":"print"},{"key":"ref15","first-page":"2372","article-title":"Association of Helicobacter pylori infection with gastric carcinoma: a meta-analysis","volume":"94","author":"Guy DE","year":"1999","journal-title":"Am J Gastroenterol","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9270","issn-type":"print"},{"key":"ref16","series-title":"Estimativa 2006: incid\u00eancia de c\u00e2ncer no Brasil","year":"2005"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1046\/j.1365-2036.2001.01052.x","article-title":"Pathogenesis of Helicobacter pylori-induced gastric inflammation","volume":"15","author":"Israel DA","year":"2001","journal-title":"Aliment Pharmacol Ther."},{"key":"ref18","first-page":"289","article-title":"Effect of Helicobacter pylori infection, smoking and dietary habits on the occurrence of antrum intestinal metaplasia: Clinico-epidemiological study in Poland","volume":"50","author":"Jedrychowski W","year":"1999","journal-title":"Pol J Pathol."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1158\/1055-9965.468.13.3","article-title":"Environmental factors in Helicobacter pylori-related gastric precancerous lesions in Venezuela","volume":"13","author":"Kato I","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev","ISSN":"https:\/\/id.crossref.org\/issn\/1055-9965","issn-type":"print"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1136\/gut.45.4.499","article-title":"Heterogeneity in the Helicobacter pylori vacA and cagA genes: association with gastroduodenal disease in south Africa?","volume":"45","author":"Kidd M","year":"1999","journal-title":"Gut","ISSN":"https:\/\/id.crossref.org\/issn\/0017-5749","issn-type":"print"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3349\/ymj.1999.40.1.14","article-title":"The comparison of histologic gastritis in patients with duodenal ulcer, chronic gastritis, gastric ulcer and gastric cancer","volume":"40","author":"Kim D","year":"1999","journal-title":"Younsei Med J"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3109\/00365529309098245","article-title":"Helicobacter pylori serology in patients with gastric carcinoma","volume":"28","author":"Kuipers EJ","year":"1993","journal-title":"Scand J Gastroenterol","ISSN":"https:\/\/id.crossref.org\/issn\/0036-5521","issn-type":"print"},{"key":"ref23","first-page":"1406","article-title":"Increased gastric epithelial cell apoptosis associated with colonization with cagA+ Helicobacter pylori strains","volume":"61","author":"Moss SF","year":"2001","journal-title":"Cancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"ref24","series-title":"Preval\u00eancia de les\u00f5es precursoras de c\u00e2ncer g\u00e1strico e de Helicobacter pylori em familiares de pacientes com c\u00e2ncer g\u00e1strico","author":"Mota CRA","year":"2004"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1023\/A:1017901110580","article-title":"Cigarette smoking promotes atrophic gastritis in Helicobacter pylori-positive subjects","volume":"47","author":"Nakamura M","year":"2002","journal-title":"Dig Dis Sci","ISSN":"https:\/\/id.crossref.org\/issn\/0163-2116","issn-type":"print"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0002-9440(10)64006-0","article-title":"Helicobacter pylori genotypes may determine gastric histopathology","volume":"158","author":"Nogueira C","year":"2001","journal-title":"Am J Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9440","issn-type":"print"},{"key":"ref27","first-page":"2201","article-title":"Seroprevalence of Helicobacter pylori infection in children of low socioeconomic level in Belo Horizonte, Brazil","volume":"89","author":"Oliveira AMR","year":"1994","journal-title":"Am J Gastroenterol","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9270","issn-type":"print"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","article-title":"Global cancer statistics, 2002","volume":"55","author":"Parkin DM","year":"2005","journal-title":"CA Cancer J Clin","ISSN":"https:\/\/id.crossref.org\/issn\/0007-9235","issn-type":"print"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1056\/NEJM199110173251603","article-title":"Helicobacter pylori infection and the risk of gastric carcinoma","volume":"325","author":"Parsonnet J","year":"1991","journal-title":"N Engl J Med","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/gut.40.3.297","article-title":"Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection","volume":"40","author":"Parsonnet J","year":"1997","journal-title":"Gut","ISSN":"https:\/\/id.crossref.org\/issn\/0017-5749","issn-type":"print"},{"key":"ref31","first-page":"6124","article-title":"Helicobacter pylori strain-specific genotypes and modulation of the gastric epithelial cell cycle","volume":"59","author":"Peek RM Jr","year":"1999","journal-title":"Cancer Res","ISSN":"https:\/\/id.crossref.org\/issn\/0008-5472","issn-type":"print"},{"key":"ref32","first-page":"1525","article-title":"Studies in abattoir workers and pigs [letter]","volume":"87","author":"Rocha GA","year":"1992","journal-title":"Am J Gastroenterol","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9270","issn-type":"print"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3109\/00365529509096338","article-title":"Lack of association of Helicobacter pylori seroprevalence and gastric cancer in a population with low gastric cancer incidence","volume":"30","author":"Rudi J","year":"1995","journal-title":"Scand J Gastroenterol."},{"key":"ref34","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1440-1746.1991.tb01472.x","article-title":"The Sydney system: epidemiology and natural history of chronic gastritis","volume":"6","author":"Sipponen P","year":"1991","journal-title":"J Gastroenterol Hepatol","ISSN":"https:\/\/id.crossref.org\/issn\/0815-9319","issn-type":"print"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3109\/00365529309098333","article-title":"Role of Helicobacter pylori in the pathogenesis of gastritis, peptic ulcer and gastric cancer","volume":"196","author":"Sipponen P","year":"1993","journal-title":"Scand J Gastroenterol","ISSN":"https:\/\/id.crossref.org\/issn\/0036-5521","issn-type":"print"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1155\/2001\/367832","article-title":"The updated Sydney system: classification and grading of gastritis as the basis of diagnosis and treatment","volume":"15","author":"Stolte M","year":"2001","journal-title":"Can J Gastroenterol","ISSN":"https:\/\/id.crossref.org\/issn\/0835-7900","issn-type":"print"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1093\/jnci\/83.23.1734","article-title":"Gastric adenocarcinoma and Helicobacter pylori infection","volume":"83","author":"Talley NJ","year":"1991","journal-title":"J Natl Cancer Inst","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8874","issn-type":"print"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1097\/00004836-199604000-00006","article-title":"Helicobacter pylori serology in chronic gastritis with antral atrophy and negative histology for Helicobacter-like organism","volume":"22","author":"Testoni PA","year":"1996","journal-title":"J Clin Gastroenterol","ISSN":"https:\/\/id.crossref.org\/issn\/0192-0790","issn-type":"print"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/00004836-200209000-00007","article-title":"In diffuse atrophic gastritis, routine histology underestimates Helicobacter pylori infection","volume":"35","author":"Testoni PA","year":"2002","journal-title":"J Clin Gastroenterol","ISSN":"https:\/\/id.crossref.org\/issn\/0192-0790","issn-type":"print"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/(SICI)1097-0215(19970807)72:4<565::AID-IJC3>3.0.CO;2-O","article-title":"Tobacco smoking and gastric cancer: review and meta-analysis","volume":"72","author":"Tr\u00e9ndaniel J","year":"1997","journal-title":"Int J Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0020-7136","issn-type":"print"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1056\/NEJMoa001999","article-title":"Helicobacter pylori infection and the development of gastric cancer","volume":"345","author":"Uemura N","year":"2001","journal-title":"N Engl J Med","ISSN":"https:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref42","series-title":"Food, nutrition and the prevention of cancer: a global perspective","first-page":"148","year":"1997"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1093\/jnci\/92.19.1607","article-title":"Gastric dysplasia and gastric cancer: Helicobacter pylori, serum vitamin C, and other risk factors","volume":"92","author":"You W-C","year":"2000","journal-title":"J Natl Cancer Inst","ISSN":"https:\/\/id.crossref.org\/issn\/0027-8874","issn-type":"print"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"791","DOI":"10.3748\/wjg.v11.i6.791","article-title":"Helicobacter pylori infection, glandular atrophy and intestinal metaplasia in superficial gastritis, gastric erosion, erosive gastritis, gastric ulcer and early gastric cancer","volume":"11","author":"Zhang C","year":"2005","journal-title":"World J Gastroenterol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3748\/wjg.v6.i3.428","article-title":"Research of Helicobacter pylori infection in precancerous gastric lesions","volume":"6","author":"Zhuang XQ","year":"2000","journal-title":"World J Gastroenterol"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ag\/v44n2\/a02v44n2.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T01:05:56Z","timestamp":1658883956000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032007000200002&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["S0004-28032007000200002"],"URL":"https:\/\/doi.org\/10.1590\/s0004-28032007000200002","relation":{},"ISSN":["0004-2803"],"issn-type":[{"value":"0004-2803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6]]}}}