{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:12:32Z","timestamp":1791943952501,"version":"4.3.4"},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:p>RACIONAL: A doen\u00e7a de Crohn \u00e9 uma doen\u00e7a inflamat\u00f3ria intestinal que pode estar associada a v\u00e1rias complica\u00e7\u00f5es e manifesta\u00e7\u00f5es que s\u00e3o secund\u00e1rias ao processo inflamat\u00f3rio de base. Em aproximadamente 30% dos pacientes t\u00eam sido encontradas manifesta\u00e7\u00f5es extra-intestinais. A nefrolit\u00edase \u00e9 uma delas e a forma\u00e7\u00e3o de c\u00e1lculos \u00e9 mais comum nestes pacientes do que na popula\u00e7\u00e3o em geral, principalmente c\u00e1lculos de oxalato de c\u00e1lcio. OBJETIVOS: Avaliar os fatores metab\u00f3licos urin\u00e1rios potencialmente envolvidos na forma\u00e7\u00e3o de c\u00e1lculos renais em pacientes com doen\u00e7a de Crohn. M\u00c9TODOS: Foram avaliados 29 pacientes com doen\u00e7a de Crohn atendidos no Ambulat\u00f3rio de Doen\u00e7as Inflamat\u00f3rias do Hospital de Cl\u00ednicas da Universidade Estadual de Londrina, PR, no per\u00edodo de janeiro a dezembro de 2004. A avalia\u00e7\u00e3o metab\u00f3lica incluiu medidas s\u00e9ricas e urin\u00e1rias de subst\u00e2ncias relacionadas \u00e0 lit\u00edase renal, ultra-sonografia de rins e vias urin\u00e1rias e c\u00e1lculo da supersatura\u00e7\u00e3o urin\u00e1ria para o oxalato de c\u00e1lcio, \u00e1cido \u00farico e fosfato de c\u00e1lcio. RESULTADOS: Dos 29 pacientes avaliados, 65,5% eram do sexo feminino e 34,5% do masculino. As principais altera\u00e7\u00f5es metab\u00f3licas urin\u00e1rias encontradas foram 72,41% de hipocitrat\u00faria, 41,4% de hipomagnesi\u00faria, 13,6% de hiperoxal\u00faria e 17,24% de baixo volume urin\u00e1rio. Foram encontrados c\u00e1lculos renais em 13 pacientes (44,8%). Os pacientes submetidos a cirurgia intestinal, com ressec\u00e7\u00e3o ileal, apresentaram altera\u00e7\u00f5es na satura\u00e7\u00e3o urin\u00e1ria de oxalato e fosfato. Para a compara\u00e7\u00e3o das m\u00e9dias, utilizou-se o teste de Mann-Whitney e para determinar a associa\u00e7\u00e3o entre as vari\u00e1veis foi utilizado o teste do Qui-quadrado ou o teste exato de Fisher com um n\u00edvel de signific\u00e2ncia de 5%. CONCLUS\u00c3O: A freq\u00fc\u00eancia de pacientes com c\u00e1lculos renais foi maior que a encontrada na popula\u00e7\u00e3o geral e acima do descrito em trabalhos similares. As altera\u00e7\u00f5es encontradas como hipocitrat\u00faria e a hipomagnesi\u00faria, que representam fatores de risco reconhecido para a forma\u00e7\u00e3o de c\u00e1lculos, devem ter participa\u00e7\u00e3o ativa nestes resultados. O impacto dessas altera\u00e7\u00f5es, medido pela satura\u00e7\u00e3o urin\u00e1ria elevada de oxalato e fosfato de c\u00e1lcio, representa uma das maneiras de se demonstrar como estes fatores predisp\u00f5em \u00e0 nuclea\u00e7\u00e3o de cristais e, conseq\u00fcentemente, \u00e0 forma\u00e7\u00e3o de c\u00e1lculos nas vias urin\u00e1rias.<\/jats:p>","DOI":"10.1590\/s0004-28032007000300006","type":"journal-article","created":{"date-parts":[[2007,11,28]],"date-time":"2007-11-28T23:02:24Z","timestamp":1196290944000},"page":"210-214","source":"Crossref","is-referenced-by-count":12,"title":["Doen\u00e7a de Crohn e c\u00e1lculo renal: muito mais que coincid\u00eancia?"],"prefix":"10.1590","volume":"44","author":[{"given":"Maria Lenise Lopes","family":"Viana","sequence":"first","affiliation":[{"name":"Universidade Estadual de Londrina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rose Meire Albuquerque","family":"Pontes","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Londrina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldir Eduardo","family":"Garcia","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Londrina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Em\u00edlia","family":"F\u00e1vero","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Londrina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Cavenaghi","family":"Prete","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Londrina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiemi","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Universidade Estadual de 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