{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T04:59:17Z","timestamp":1768625957015,"version":"3.49.0"},"reference-count":50,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>RACIONAL: A esofagite eosinof\u00edlica \u00e9 uma entidade recentemente descrita, caracterizada por sintomas esof\u00e1gicos, semelhantes aos da doen\u00e7a por refluxo gastroesof\u00e1gico e importante eosinofilia esof\u00e1gica. OBJETIVO: Apresenta\u00e7\u00e3o de 29 pacientes com esofagite eosinof\u00edlica, discutindo as caracter\u00edsticas cl\u00ednicas, diagn\u00f3stico, tratamento e evolu\u00e7\u00e3o. M\u00c9TODOS: Foram identificados 29 pacientes (22 do sexo masculino) com idade entre 1 e 18 anos, nos quais as biopsias de es\u00f4fago demonstraram contagem de 20 ou mais eosin\u00f3filos\/campo de grande aumento, sem infiltra\u00e7\u00e3o eosinof\u00edlica em antro e\/ou duodeno. Avaliaram-se as manifesta\u00e7\u00f5es cl\u00ednicas, achados endosc\u00f3picos e histol\u00f3gicos, tratamento e evolu\u00e7\u00e3o. RESULTADOS: Os sintomas mais freq\u00fcentes foram v\u00f4mitos em 15 pacientes (52%) e dor abdominal em 11 (38%). Os pacientes com idade inferior a 4 anos apresentavam recusa alimentar e baixo peso. Os com idades entre 5 e 8 anos apresentavam predominantemente dor abdominal e\/ou pirose e\/ou v\u00f4mitos. Os pacientes com mais de 8 anos apresentavam dor abdominal, disfagia e\/ou impacta\u00e7\u00e3o alimentar eventual. Os achados endosc\u00f3picos inclu\u00edram estrias verticais em 14 pacientes (48%), pontilhado branco em 12 (41%), an\u00e9is circulares em 2 (7%) e esofagite erosiva em 3 (10%). Em sete pacientes a endoscopia foi normal (24%). O tratamento incluiu fluticasona t\u00f3pica em 19 pacientes e restri\u00e7\u00e3o diet\u00e9tica em 7. Os pacientes acompanhados apresentaram resposta favor\u00e1vel ao tratamento, com melhora ou remiss\u00e3o dos sintomas. Onze pacientes que foram submetidos a endoscopia de controle p\u00f3s-tratamento apresentaram diminui\u00e7\u00e3o significativa do n\u00famero de eosin\u00f3filos no es\u00f4fago. CONCLUS\u00d5ES: A esofagite eosinof\u00edlica deve ser considerada quando h\u00e1 sintomas de refluxo, que n\u00e3o respondem ao tratamento habitual. Os exames endosc\u00f3picos devem ser acompanhados de biopsias com an\u00e1lise detalhada do n\u00famero de eosin\u00f3filos.<\/jats:p>","DOI":"10.1590\/s0004-28032008000200010","type":"journal-article","created":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T03:08:13Z","timestamp":1215659293000},"page":"141-146","source":"Crossref","is-referenced-by-count":17,"title":["Esofagite eosinof\u00edlica em 29 pacientes pedi\u00e1tricos"],"prefix":"10.1590","volume":"45","author":[{"given":"Cristina Targa","family":"Ferreira","sequence":"first","affiliation":[{"name":"Instituto do Aparelho Digestivo; Hospital de Cl\u00ednicas de Porto Alegre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rio C.","family":"Vieira","sequence":"additional","affiliation":[{"name":"Hospital Pequeno Pr\u00edncipe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Maria Gon\u00e7alves","family":"Vieira","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovana Stival da","family":"Silva","sequence":"additional","affiliation":[{"name":"Hospital Pequeno Pr\u00edncipe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle Reis","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Hospital Pequeno Pr\u00edncipe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Themis Reverbel da","family":"Silveira","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1053\/j.gastro.2005.06.027","article-title":"Epicutaneous antigen exposure primes for experimental eosinophilic esophagitis in mice","volume":"129","author":"Akei 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