{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:11:55Z","timestamp":1790885515397,"version":"4.1.0"},"reference-count":43,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>BACKGROUND: Hepatic cirrhosis is the final stage of liver dysfunction, characterized by diffuse fibrosis which is the main response to the liver injury. The inhalatory carbon tetrachloride is an effective experimental model that triggers cirrhosis and allows to obtain histological and physiological modifications similar to the one seen in humans. AIM: To investigate the effects of N-acetylcysteine (NAC) on the fibrosis and oxidative stress in the liver of cirrhotic rats, analyzing liver function tests, lipoperoxidation, activity of glutathione peroxidase enzyme, collagen quantification, histopathology, as well as the nitric oxide role. METHODS: The animals were randomly in three experimentals groups: control (CO); cirrhotic (CCl4) and CCl4 + NAC. Evaluate the lipid peroxidation, the glutathione peroxidase enzyme, the collagen and the expression of inducible nitric oxide synthase (iNOS). RESULTS: The cirrhotic group treated with N-acetylcysteine showed trough the histological analysis and collagen quantification lower degrees of fibrosis. This group has also shown less damage to the cellular membranes, less decrease on the glutathione peroxidase levels and less expression of inducible nitric oxide synthase when matched with the cirrhotic group without treatment. CONCLUSION: N-acetylcysteine seams to offer protection against hepatic fibrosis and oxidative stress in cirrhotic rat livers.<\/jats:p>","DOI":"10.1590\/s0004-28032008000200013","type":"journal-article","created":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T03:08:23Z","timestamp":1215659303000},"page":"156-162","source":"Crossref","is-referenced-by-count":55,"title":["Role of N-acetylcysteine on fibrosis and oxidative stress in cirrhotic rats"],"prefix":"10.1590","volume":"45","author":[{"given":"Gustavo","family":"Pereira-Filho","sequence":"first","affiliation":[{"name":"Federal School of Medical Sciences of Porto Alegre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarissa","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Lutheran University of Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Schwengber","sequence":"additional","affiliation":[{"name":"Federal School of Medical Sciences of Porto Alegre"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio","family":"Marroni","sequence":"additional","affiliation":[{"name":"Federal School of Medical Sciences of Porto Alegre; Santa Casa Hospital Complex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio","family":"Zettler","sequence":"additional","affiliation":[{"name":"Federal School of Medical Sciences of Porto Alegre; Santa Casa Hospital Complex"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Marroni","sequence":"additional","affiliation":[{"name":"Lutheran University of Brazil; Federal University of Rio Grande do Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/0891-5849(89)90066-X","article-title":"The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and 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