{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:48:31Z","timestamp":1759481311952},"reference-count":33,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p>CONTEXT: Treatment of hepatorenal syndrome type 1 (HRS-1) with splancnic vasoconstrictors and high-dose albumin has been associated with reversal of renal failure in approximately 60% to 80% of the cases in pilot or uncontrolled studies. OBJECTIVE: To evaluate the results of treatment of HRS-1 with terlipressin and high-dose albumin. METHODS: All patients with HRS-1 that underwent treatment with terlipressin and high-dose albumin at our unit were retrospectively reviewed. Outcomes including reversal of renal failure and death were recorded and compared to baseline clinical and laboratory parameters. RESULTS: Seven subjects (median age 64 [47-69] years, 5 males) with median Child-Pugh and MELD scores of 12 [10-15] and 22 [17-38], respectively, hospitalized with decompensated chronic liver disease secondary to tense ascitis and infections, who exhibited criteria for HRS-1, were submitted to therapy with terlipressin and high-dose albumin according to a predefined standard protocol. Baseline creatinine levels were 2.9 [2.3-4.0] mg\/mL. None of the patients achieved reversal of HRS-1 and five subjects died on-treatment due to sudden-death (n = 1), multiple organ dysfunction associated with end-stage liver failure (n = 2) and sepsis (n = 2). CONCLUSIONS: Treatment of HRS-1 with terlipressin and high-dose albumin was not associated with reversal of renal failure, but most of the treated subjects had severe end-stage liver disease with high MELD scores as well as high baseline creatinine values, parameters previously associated with bad outcomes.<\/jats:p>","DOI":"10.1590\/s0004-28032009000300014","type":"journal-article","created":{"date-parts":[[2009,11,5]],"date-time":"2009-11-05T06:51:46Z","timestamp":1257403906000},"page":"214-218","source":"Crossref","is-referenced-by-count":3,"title":["Poor outcomes with treatment of hepatorenal syndrome type 1 with splancnic vasoconstrictors and albumin: report of seven cases and review of the literature"],"prefix":"10.1590","volume":"46","author":[{"given":"Jamile Ros\u00e1rio","family":"Kalil","sequence":"first","affiliation":[{"name":"Hospital Portugu\u00eas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liv Aparicio","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"Hospital Portugu\u00eas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Silva","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Hospital Portugu\u00eas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Pamponet","family":"Motta","sequence":"additional","affiliation":[{"name":"Hospital Portugu\u00eas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00edlia da Silva","family":"Nery","sequence":"additional","affiliation":[{"name":"Hospital Portugu\u00eas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Lisboa","family":"Bittencourt","sequence":"additional","affiliation":[{"name":"Hospital Portugu\u00eas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.jhep.2007.04.010","article-title":"Noradrenalin vs terlipressin in patients with hepatorenal syndrome: a prospective, randomized, unblinded, pilot study","volume":"47","author":"Alessandria C","year":"2007","journal-title":"J Hepatol","ISSN":"http:\/\/id.crossref.org\/issn\/0168-8278","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1002\/hep.510290629","article-title":"Reversal of type 1 hepatorenal syndrome with the administration of midodrine and octreotide","volume":"29","author":"Angeli P","year":"1999","journal-title":"Hepatology","ISSN":"http:\/\/id.crossref.org\/issn\/0161-0538","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/hep.510230122","article-title":"Definition and diagnostic criteria of refractory ascites 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