{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:29:35Z","timestamp":1790839775564,"version":"4.1.0"},"reference-count":23,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p>CONTEXT: Management of complex anal fistulas is associated with the risk of sphincter injury and fecal incontinence. In recent years, fibrin glue has emerged as an alternative sphincter-preserving treatment for anal fistulas. To date, however, there is no consensus about the efficacy of the method. OBJECTIVE: To specifically evaluate the fibrin glue injection in the management of complex cryptoglandular anal fistulas. METHODS: We studied a series of patients with complex anal fistulas treated with fibrin glue between January 2005 and January 2007. Only patients with fistulas of cryptoglandular origin were analyzed. Patients with fistulas related to Crohn's disease, HIV or previous surgery were excluded from the study. Under spinal anesthesia, the fistulas were curetted and injected with fibrin glue. After treatment, patients were followed-up for 12 months. RESULTS: Thirty-two patients were enrolled in the study. Two patients were lost to follow-up and were excluded. Out of the remaining 30 patients, only three healed successfully (10%). Among the 27 patients who failed to heal, 9 (33.3%) were diagnosed within the first postoperative month. In 13 patients (48.1%) the failure of treatment occurred in the period between 1 and 3 months, in 3 patients (11.1%) between 3 and 6 months, and in 2 patients (7.4%) between 6 and 9 months after surgery. No treatment-related complications were observed. CONCLUSIONS: In this series, fibrin glue treatment for complex cryptoglandular anal fistulas achieved a very low healing rate. Our results do not support the use of fibrin glue as a first-line treatment for patients with this type of fistula.<\/jats:p>","DOI":"10.1590\/s0004-28032009000400010","type":"journal-article","created":{"date-parts":[[2010,3,11]],"date-time":"2010-03-11T13:28:29Z","timestamp":1268314109000},"page":"300-303","source":"Crossref","is-referenced-by-count":20,"title":["Fibrin glue in the management of complex anal fistula"],"prefix":"10.1590","volume":"46","author":[{"given":"Daniel C.","family":"Damin","sequence":"first","affiliation":[{"name":"Hospital de Clinicas de Porto Alegre; Federal University of Rio Grande do Sul,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rio A.","family":"Rosito","sequence":"additional","affiliation":[{"name":"Hospital de Clinicas de Porto Alegre; Federal University of Rio Grande do Sul,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo C.","family":"Contu","sequence":"additional","affiliation":[{"name":"Hospital de Clinicas de Porto Alegre; Federal University of Rio Grande do Sul,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio","family":"Tarta","sequence":"additional","affiliation":[{"name":"Hospital de Clinicas de Porto Alegre; Federal University of Rio Grande do Sul,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1007\/s10350-008-9405-2","article-title":"Long-term outlook after successful fibrin glue ablation of cryptoglandular transsphicteric fistula-in-ano","volume":"51","author":"Adams T","year":"2008","journal-title":"Dis Colon Rectum","ISSN":"https:\/\/id.crossref.org\/issn\/0012-3706","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1007\/BF02554093","article-title":"Mucosal advancement in the treatment of anal fistula","volume":"28","author":"Aguilar PS","year":"1985","journal-title":"Dis Colon Rectum","ISSN":"https:\/\/id.crossref.org\/issn\/0012-3706","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s10350-004-6708-9","article-title":"Efficacy of fibrin sealant in the management of complex anal fistula: a prospective trial","volume":"46","author":"Buchanan GN","year":"2003","journal-title":"Dis Colon Rectum","ISSN":"https:\/\/id.crossref.org\/issn\/0012-3706","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/BF02234135","article-title":"Repair of fistulas-in-ano using autologous fibrin tissue adhesive","volume":"42","author":"Cintron JR","year":"1999","journal-title":"Dis Colon Rectum","ISSN":"https:\/\/id.crossref.org\/issn\/0012-3706","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1007\/BF02237355","article-title":"Repair of fistulas-in-ano 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repair of rectovaginal and other complicated anorectal fistulas","volume":"114","author":"Kodner IJ","year":"1993","journal-title":"Surgery","ISSN":"https:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1007\/s10350-004-7247-0","article-title":"A randomized, controlled trial of fibrin glue vs: conventional treatment for anal fistula","volume":"45","author":"Lindsey I","year":"2002","journal-title":"Dis Colon Rectum","ISSN":"https:\/\/id.crossref.org\/issn\/0012-3706","issn-type":"print"},{"key":"ref14","first-page":"26:86","article-title":"O emprego da cola de fibrina no tratamento das f\u00edstulas anais","author":"Lopes-Paulo F","year":"2006","journal-title":"Rev Bras Coloproctol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1007\/s10350-003-0076-8","article-title":"Fibrin glue treatment of complex anal fistulas has low success rate","volume":"47","author":"Loungnarath 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