{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:29:08Z","timestamp":1759530548585},"reference-count":27,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p>CONTEXTO: A doen\u00e7a cel\u00edaca \u00e9 uma enteropatia autoimune causada pela sensibilidade ao gl\u00faten em indiv\u00edduos geneticamente predispostos. Apesar da caracter\u00edstica gen\u00e9tica da doen\u00e7a, estudos demonstram discord\u00e2ncia de 30% na sua apresenta\u00e7\u00e3o em g\u00eameos monozig\u00f3ticos. OBJETIVO: Apresentar dois pares de g\u00eameos monozig\u00f3ticos, comprovados por estudos gen\u00e9ticos, discordantes para apresenta\u00e7\u00e3o da doen\u00e7a cel\u00edaca. M\u00c9TODO: Os pacientes foram acompanhados no Servi\u00e7o de Gastroenterologia Pedi\u00e1trica do Hospital das Cl\u00ednicas da Universidade Federal de Minas Gerais desde 1990, sendo submetidos a exames cl\u00ednicos peri\u00f3dicos, biopsias intestinais e sorologia para anticorpos IgG e IgA antigliadina, determinados pela t\u00e9cnica de ELISA (ensaio imunoenzim\u00e1tico), e anticorpos classe IgA antiendom\u00edsio, determinados pela t\u00e9cnica de imunofluoresc\u00eancia indireta. Estudos gen\u00e9ticos foram realizados atrav\u00e9s da t\u00e9cnica de amplifica\u00e7\u00e3o por PCR e posterior tipagem de loci de microssat\u00e9lites do tipo STR (short tandem repeats). RESULTADOS: Em cada par de g\u00eameos, apenas um apresentou doen\u00e7a cel\u00edaca at\u00e9 o momento, mostrando que, apesar do gen\u00f3tipo id\u00eantico, este n\u00e3o foi o \u00fanico determinante para a express\u00e3o da doen\u00e7a. CONCLUS\u00c3O: Outros fatores, ambientais e gen\u00e9ticos, parecem contribuir para determina\u00e7\u00e3o da doen\u00e7a.<\/jats:p>","DOI":"10.1590\/s0004-28032010000100010","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T20:03:44Z","timestamp":1490817824000},"page":"56-60","source":"Crossref","is-referenced-by-count":4,"title":["Discord\u00e2ncia de apresenta\u00e7\u00e3o da doen\u00e7a cel\u00edaca em g\u00eameos monozig\u00f3ticos"],"prefix":"10.1590","volume":"47","author":[{"given":"Magda","family":"Bahia","sequence":"first","affiliation":[{"name":"Universidade Federal de Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Jos\u00e9","family":"Penna","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dora Mendez Del","family":"Castillo","sequence":"additional","affiliation":[{"name":"UFMG"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina Guimar\u00e3es Corr\u00ea","family":"Hassegawa","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline Cristina","family":"Vieira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa Ribeiro","family":"Orlando","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1572-0241.2003.07238.x","article-title":"Prevalence of celiac disease among relatives of sib pairs with celiac disease in U. 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