{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T13:26:57Z","timestamp":1762522017313},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:p>CONTEXT: In infants, it is not always easy to distinguish between pathological and physiological gastroesophageal reflux based only on clinical criteria. In Brazil, studies about gastroesophageal reflux disease in infants are few and are even rare those that used prolonged esophageal pH monitoring for its evaluation. OBJECTIVE: To describe the clinical features of gastroesophageal reflux disease and to determine its prevalence in infants with gastroesophageal reflux attending a tertiary Pediatric Gastroenterology Service and submitted to esophageal pH monitoring for investigation. METHODS: Descriptive study in 307 infants in whom esophageal pH monitoring (Mark III Digitrapper, Synectics Medical AB, Sweden) was performed during the period December, 1998-December, 2008. The clinical features studied were age group (1-12 months and 13-24 months), and clinical manifestations that motivated the indication of pH monitoring. RESULTS: One hundred twenty-four (40.4%) were female and 183 (59.6%) male with mean age 12.2 \u00b1 6.2 months (1-23 months). The prevalence of gastroesophageal reflux disease was 18.2% (56\/307). One hundred forty-eight (48.2%) were 1-12 months old and 159 (51.8%), 13-24 months. No significant difference was found between the prevalence of these two age groups (P = 0.3006). Gastroesophageal reflux disease was more frequent in those with digestive manifestations (24.2%), crisis of cyanosis\/apnea (23.8%) and mixed manifestations (21.5%). Respiratory manifestations were the most frequent indication (39.1%) of pH monitoring. However, the prevalence of gastroesophageal reflux disease was lower (12.5%) in this group compared with in those with digestive manifestations (P = 0.0574), crisis of cyanosis\/apnea (P = 0.0882) and mixed manifestations (P = 0.1377). All infants that presented clinical manifestations as crisis of cyanosis\/apnea and abnormal pH-metry were &lt; 3 months of age. CONCLUSIONS: In our Service, the prevalence of gastroesophageal reflux disease associated with acid reflux in infants revealed elevated. Infants with crisis of cyanosis\/apnea constitute risk population for gastroesophageal reflux disease in which diagnostic investigation needs to be considered.<\/jats:p>","DOI":"10.1590\/s0004-28032010000100012","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T20:40:49Z","timestamp":1490992849000},"page":"66-71","source":"Crossref","is-referenced-by-count":7,"title":["Clinical features and prevalence of gastroesophageal reflux disease in infants attending a pediatric gastroenterology reference service"],"prefix":"10.1590","volume":"47","author":[{"given":"Yu Kar Ling","family":"Koda","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos J","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Murasca","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana","family":"Vidolin","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Pediatric gastroenterology","first-page":"214","volume-title":"Normal and abnormal GI motility","author":"Aronow E","year":"1983"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0889-8553(21)00680-4","article-title":"Gastroesophageal reflux in the pediatric patient","volume":"18","author":"Boyle JT","year":"1989","journal-title":"Gastroenterol Clin North Am."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1136\/adc.34.176.344","article-title":"The natural history of the partial thoracic stomach (hiatus hernia) in children","volume":"34","author":"Carr\u00e9 IJ","year":"1959","journal-title":"Arch Dis Child."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1590\/S0021-75572004000500008","article-title":"Preval\u00eancia de RGE patol\u00f3gico em lactentes regurgitadores","volume":"80","author":"Costa AJF","year":"2004","journal-title":"J Pediatr (Rio J)."},{"key":"ref5","first-page":"452","article-title":"Refluxo gastroesof\u00e1gico em lactentes hospitalizados: estudo comparativo entre dois grupos","volume":"59","author":"Domingues CHD","year":"1985","journal-title":"J Pediatr (Rio J)."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1001\/archinte.1996.00440050019003","article-title":"Suggested disease management guidelines","volume":"156","author":"Fennerty MB","year":"1996","journal-title":"Arch Intern Med."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1590\/S0004-28032005000300009","article-title":"Predom\u00ednio de manifesta\u00e7\u00f5es respirat\u00f3rias na indica\u00e7\u00e3o de pHmetria esof\u00e1gica prolongada em crian\u00e7as","volume":"42","author":"Goldani HAS","year":"2005","journal-title":"Arq. 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