{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:09:39Z","timestamp":1759961379725},"reference-count":65,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:p>CONTEXT: Diabetes mellitus type I affects around 240 million people in the world and only in the USA 7.8% of the population. It has been estimated that the costs of its complications account for 5% to 10% of the total healthcare spending around the world. According to World Health Organization, 300 million people are expected to develop diabetes mellitus by the year 2025. The pancreatic islet transplantation is expected to be less invasive than a pancreas transplant, which is currently the most commonly used approach. OBJECTIVES: To compare the encapsulated and free islet transplantation in rodents looking at sites of islet implantation, number of injected islets, viability and immunosuppression. METHODS: A literature search was conducted using MEDLINE\/PUBMED and SCIELO with terms about islet transplantation in the rodent from 2000 to 2010. We found 2,636 articles but only 56 articles from 2000 to 2010 were selected. RESULTS: In these 56 articles used, 34% were encapsulated and 66% were nonencapsulated islets. Analyzing both types of islets transplantation, the majority of the encapsulated islets were implanted into the peritoneal cavity and the nonencapsulated islets into the liver, through the portal vein. In addition, the great advantage of the peritoneal cavity as the site of islet transplantation is its blood supply. Both vascular endothelial cells and vascular endothelial growth factor were used to stimulate angiogenesis of the islet grafts, increasing the vascularization rapidly after implantation. It also has been proven that there is influence of the capsules, since the larger the capsule more chances there are of central necrosis. In some articles, the use of immunosuppression demonstrated to increase the life expectancy of the graft. CONCLUSION: While significant progress has been made in the islets transplantation field, many obstacles remain to be overcome. Microencapsulation provides a means to transplant islets without immunosuppressive agents and may enable the performance of xenotransplantation. The use of alternative donor sources, fewer islets per capsule and the appropriate deployment location, such as the peritoneal cavity, may give a future perspective to the application of immunoprotective capsules and viability in clinical practice. A variety of strategies, such as genetic engineering, co-encapsulation, improvement in oxygen supply or the establishment of hypoxia resistance will also improve the islet transplantation performance. It remains to be determined which combination of strategies with encapsulation can fulfill the promise of establishing a simple and safe transplantation as a cure for diabetes.<\/jats:p>","DOI":"10.1590\/s0004-28032011000200011","type":"journal-article","created":{"date-parts":[[2011,6,20]],"date-time":"2011-06-20T17:16:45Z","timestamp":1308590205000},"page":"146-152","source":"Crossref","is-referenced-by-count":22,"title":["Islet transplantation in rodents: do encapsulated islets really work?"],"prefix":"10.1590","volume":"48","author":[{"given":"Yngrid Ellyn Dias Maciel de","family":"Souza","sequence":"first","affiliation":[{"name":"Universidade Nove de Julho"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleazar","family":"Chaib","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia Gra\u00e7a de","family":"Lacerda","sequence":"additional","affiliation":[{"name":"Universidade Nove de Julho"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Crescenzi","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnaldo","family":"Bernal-Filho","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Augusto Carneiro","family":"D'Albuquerque","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Os custos do diabetes mellitus","author":"Bahia L."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1399-3089.2007.00409.x","article-title":"Effect of various immunosuppressive monotherapies on survival and histopathology of monkey islet xenografts in rats","volume":"14","author":"Balamurugan AN","year":"2007","journal-title":"Xenotransplantation","ISSN":"http:\/\/id.crossref.org\/issn\/0908-665X","issn-type":"print"},{"key":"ref3","first-page":"372","article-title":"[Cytoprotective effect of low-dose tacrolimus on islets of Langerhans in cultures subjected to stimulation by acute rejection cytokines].","volume":"87","author":"Balibrea del Castillo JM","year":"2010","journal-title":"Cir Esp","ISSN":"http:\/\/id.crossref.org\/issn\/0009-739X","issn-type":"print"},{"key":"ref4","first-page":"44","article-title":"[Isogenic islet transplantation on the rat liver ].","volume":"37","author":"Chaib E","year":"2000","journal-title":"Arq Gastroenterol","ISSN":"http:\/\/id.crossref.org\/issn\/0004-2803","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2862","DOI":"10.3748\/wjg.v13.i20.2862","article-title":"Elevation of vascular endothelial growth factor production and its effect on revascularization and function of graft islets in diabetic rats","volume":"13","author":"Cheng Y","year":"2007","journal-title":"World J Gastroenterol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jss.2003.07.008","article-title":"Macrophage overgrowth affects neighboring nonovergrown encapsulated islets","volume":"115","author":"de Groot M","year":"2003","journal-title":"J Surg Res","ISSN":"http:\/\/id.crossref.org\/issn\/0022-4804","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1007\/s001250050673","article-title":"Improved biocompatibility but limited graft survival after purification of alginate for microencapsulation of pancreatic islets","volume":"40","author":"De Vos P","year":"1997","journal-title":"Diabetologia","ISSN":"http:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.2337\/diabetes.48.7.1381","article-title":"Why do microencapsulated islet grafts fail in the absence of fibrotic overgrowth","volume":"48","author":"De Vos P","year":"1999","journal-title":"Diabetes","ISSN":"http:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"515","DOI":"10.3727\/000000004783983738","article-title":"Factors influencing functional survival of microencapsulated islet grafts","volume":"13","author":"de Vos P","year":"2004","journal-title":"Cell Transplant","ISSN":"http:\/\/id.crossref.org\/issn\/0963-6897","issn-type":"print"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1111\/j.1600-6143.2010.03190.x","article-title":"Induction of indoleamine 2, 3-dioxygenase by gene delivery in allogeneic islets prolongs allograft survival","volume":"10","author":"Dell\u00ea H","year":"2010","journal-title":"Am J Transplant"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"5640","DOI":"10.1016\/j.biomaterials.2005.02.019","article-title":"Subcutaneous xenotransplantation of bovine pancreatic islets","volume":"26","author":"Figliuzzi M","year":"2005","journal-title":"Biomaterials","ISSN":"http:\/\/id.crossref.org\/issn\/0142-9612","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1016\/j.transproceed.2008.11.015","article-title":"Bone marrow-derived mesenchymal stem cells improve islet graft function in diabetic rats","volume":"41","author":"Figliuzzi M","year":"2009","journal-title":"Transplant Proc","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1345","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.3748\/wjg.v11.i18.2733","article-title":"Effects of mycophenolate mofetil vs cyclosporine administration on graft survival and function after islet allotransplantation in diabetic rats","volume":"11","author":"Fotiadis C","year":"2005","journal-title":"World J Gastroenterol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1006\/bbrc.2001.5563","article-title":"Recovery of function and mass of endogenous beta-cells in streptozotocin-induced diabetic rats treated with islet transplantation","volume":"287","author":"Hamamoto Y","year":"2001","journal-title":"Biochem Biophys Res Commun","ISSN":"http:\/\/id.crossref.org\/issn\/0006-291X","issn-type":"print"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3181\/0812-RM-359","article-title":"Transplantation of sertoli-islet cell aggregates formed by microgravity: prolonged survival in diabetic rats","volume":"234","author":"Han X","year":"2009","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1016\/j.transproceed.2006.08.002","article-title":"Influence of the numbers of islets on the models of rat syngeneic-islet and allogeneic-islet transplantations","volume":"38","author":"Hara Y","year":"2006","journal-title":"Transplant Proc","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1345","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1530\/eje.0.1440521","article-title":"Influence of a high-fat diet during chronic hyperglycemia on beta-cell function in pancreatic islet transplants to streptozotocin-diabetic rats","volume":"144","author":"Hiramatsu S","year":"2001","journal-title":"Eur J Endocrinol","ISSN":"http:\/\/id.crossref.org\/issn\/0804-4643","issn-type":"print"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/00007890-200202270-00004","article-title":"Treatment of streptozotocin-induced diabetes mellitus by transplantation of islet cells plus bone marrow cells via portal vein in rats","volume":"73","author":"Ikebukuro K","year":"2002","journal-title":"Transplantation","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1337","issn-type":"print"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/sj.bmt.1705500","article-title":"Synergistic effects of injection of bone marrow cells into both portal vein and bone marrow on tolerance induction in transplantation of allogeneic pancreatic islets","volume":"38","author":"Ikebukuro K","year":"2006","journal-title":"Bone Marrow Transplant","ISSN":"http:\/\/id.crossref.org\/issn\/0268-3369","issn-type":"print"},{"key":"ref20","series-title":"Why you should care","year":"2010"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1111\/j.1432-2277.2009.00939.x","article-title":"Angiostatic factors normally restrict islet endothelial cell proliferation and migration: implications for islet transplantation","volume":"22","author":"Johansson A","year":"2009","journal-title":"Transpl Int","ISSN":"http:\/\/id.crossref.org\/issn\/0934-0874","issn-type":"print"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/00006676-200111000-00007","article-title":"Successful subcutaneous pancreatic islet transplantation using an angiogenic growth factor-releasing device","volume":"23","author":"Kawakami Y","year":"2001","journal-title":"Pancreas","ISSN":"http:\/\/id.crossref.org\/issn\/0885-3177","issn-type":"print"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/244447a0","article-title":"Transplantation of isolated pancreatic islets into the portal vein of diabetic rats","volume":"244","author":"Kemp CB","year":"1973","journal-title":"Nature","ISSN":"http:\/\/id.crossref.org\/issn\/0028-0836","issn-type":"print"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1034\/j.1399-5448.2001.20407.x","article-title":"CD40\/154 blockade and rejection of islet allografts in the streptozotocin and autoimmune diabetic rat","volume":"2","author":"Kover KL","year":"2001","journal-title":"Pediatr Diabetes"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2337\/diab.16.1.35","article-title":"Method for the isolation of intact islets of Langerhans from the rat pancreas","volume":"16","author":"Lacy P","year":"1967","journal-title":"Diabetes","ISSN":"http:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2337\/diab.27.4.427","article-title":"Workshop on pancreatic islet cell transplantation in diabetes sponsored by the National Institute of Arthritis, Metabolism, and Digestive Diseases and held at the National Institutes of Health in Bethesda, Maryland, on November 29 and 30, 1977","volume":"27","author":"Lacy P","year":"1978","journal-title":"Diabetes","ISSN":"http:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"key":"ref27","first-page":"1026","article-title":"Immune privilege induced by cotransplantation of islet and allogeneic testicular cells","volume":"114","author":"Lan P","year":"2001","journal-title":"Chin Med J (Engl)","ISSN":"http:\/\/id.crossref.org\/issn\/0366-6999","issn-type":"print"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1089\/104303403764539341","article-title":"CTLA4Ig adenoviral gene transfer induces long-term islet rat allograft survival, without tolerance, after systemic but not local intragraft expression","volume":"14","author":"Laumonier T","year":"2003","journal-title":"Hum Gene Ther","ISSN":"http:\/\/id.crossref.org\/issn\/1043-0342","issn-type":"print"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.2337\/db07-0460","article-title":"Metabolic mechanisms of failure of intraportally transplanted pancreatic beta-cells in rats: role of lipotoxicity and prevention by leptin","volume":"56","author":"Lee DY","year":"2007","journal-title":"Diabetes","ISSN":"http:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1097\/01.TP.0000061770.39569.7F","article-title":"Immunosuppression with FTY720 and cyclosporine A inhibits rejection of adult porcine islet xenografts in rats","volume":"75","author":"Maeda A","year":"2003","journal-title":"Transplantation","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1337","issn-type":"print"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1097\/00007890-199711150-00013","article-title":"The cytokine and histological response in islet xenograft rejection is dependent upon species combination","volume":"64","author":"Medbury HJ","year":"1997","journal-title":"Transplantation","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1337","issn-type":"print"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/TP.0b013e31819198b4","article-title":"Protein kinase C inhibitor, AEB-071, acts complementarily with cyclosporine to prevent islet rejection in rats","volume":"87","author":"Merani S","year":"2009","journal-title":"Transplantation","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1337","issn-type":"print"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jss.2009.06.003","article-title":"Fibroblast growth factor-1 (FGF-1) loaded microbeads enhance local capillary neovascularization","volume":"160","author":"Moya ML","year":"2010","journal-title":"J Surg Res","ISSN":"http:\/\/id.crossref.org\/issn\/0022-4804","issn-type":"print"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1097\/00007890-200007270-00007","article-title":"Local blood flow regulation in transplanted rat pancreatic islets: influence of adenosine, angiotensin II, and nitric oxide inhibition","volume":"70","author":"Olsson R","year":"2000","journal-title":"Transplantation","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1337","issn-type":"print"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"360","DOI":"10.2337\/diabetes.53.2.360","article-title":"Exercise induces hypoglycemia in rats with islet transplantation","volume":"53","author":"Omer A","year":"2004","journal-title":"Diabetes","ISSN":"http:\/\/id.crossref.org\/issn\/0012-1797","issn-type":"print"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s00125-009-1653-8","article-title":"Rat islet cell aggregates are superior to islets for transplantation in microcapsules","volume":"53","author":"O'Sullivan ES","year":"2010","journal-title":"Diabetologia","ISSN":"http:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1126\/science.2119056","article-title":"Induction of donor-specific umrespponsiveness by intrathymic islet transplantation","volume":"249","author":"Posset AM","year":"1990","journal-title":"Science","ISSN":"http:\/\/id.crossref.org\/issn\/0036-8075","issn-type":"print"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1016\/j.biomaterials.2010.01.088","article-title":"The in vivo performance of polyvinyl alcohol macro-encapsulated islets","volume":"31","author":"Qi Z","year":"2010","journal-title":"Biomaterials","ISSN":"http:\/\/id.crossref.org\/issn\/0142-9612","issn-type":"print"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1007\/s00125-009-1537-y","article-title":"Regression of diabetic complications by islet transplantation in the rat","volume":"52","author":"Remuzzi A","year":"2009","journal-title":"Diabetologia","ISSN":"http:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3727\/096368909X484257","article-title":"Transplantation of long-term cultured porcine islets in the rat: prolonged graft survival and recipient growth on reduced immunosuppression","volume":"19","author":"Rijkelijkhuizen JK","year":"2010","journal-title":"Cell Transplant","ISSN":"http:\/\/id.crossref.org\/issn\/0963-6897","issn-type":"print"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.amjsurg.2007.12.040","article-title":"Pancreatic islet transplantation into the bone marrow of the rat","volume":"195","author":"Salazar-Ba\u00f1uelos A","year":"2008","journal-title":"Am J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9610","issn-type":"print"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/S0041-1345(01)02285-0","article-title":"Induction of systemic tolerance in islet allograft by liver transplantation","volume":"33","author":"Sawada T","year":"2001","journal-title":"Transplant Proc","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1345","issn-type":"print"},{"key":"ref43","first-page":"100","article-title":"Transplantation of islets of Langerhans in diabetic rhesus monkeys","volume":"77","author":"Scharp DW","year":"1975","journal-title":"Surgery","ISSN":"http:\/\/id.crossref.org\/issn\/0039-6060","issn-type":"print"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1046\/j.1525-1594.2003.07159.x","article-title":"Intraportal transplantation of allogenic pancreatic islets encapsulated in barium alginate beads in diabetic rats","volume":"27","author":"Schneider S","year":"2003","journal-title":"Artif Organs","ISSN":"http:\/\/id.crossref.org\/issn\/0160-564X","issn-type":"print"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","article-title":"Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen","volume":"343","author":"Shapiro AM","year":"2000","journal-title":"N Engl J Med","ISSN":"http:\/\/id.crossref.org\/issn\/0028-4793","issn-type":"print"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s00125-006-0251-2","article-title":"Exendin-4 treatment improves metabolic control after rat islet transplantation to athymic mice with streptozotocin-induced diabetes","volume":"49","author":"Sharma A","year":"2006","journal-title":"Diabetologia","ISSN":"http:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0041-1345(01)02878-0","article-title":"Survival of islet allografts under kidney capsule in the recipient preconditioned with or without myeloablation and treated with UVB-irradiated donor bone marrow infusion","volume":"34","author":"Socha-Urbanek K","year":"2002","journal-title":"Transplant Proc","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1345","issn-type":"print"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/01.tp.0000228912.62374.44","article-title":"Macroencapsulation protects against sensitization after allogeneic islet transplantation in rats","volume":"82","author":"S\u00f6renby AK","year":"2006","journal-title":"Transplantation","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1337","issn-type":"print"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1097\/TP.0b013e31817efc78","article-title":"Preimplantation of an immunoprotective device can lower the curative dose of islets to that of free islet transplantation: studies in a rodent model","volume":"86","author":"S\u00f6renby AK","year":"2008","journal-title":"Transplantation","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1337","issn-type":"print"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/S0041-1345(02)02769-0","article-title":"Successful islet transplantation does not prevent the development of neuropathy in alloxan-induced diabetic rats","volume":"34","author":"Spadella CT","year":"2002","journal-title":"Transplant Proc","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1345","issn-type":"print"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.1111\/j.1582-4934.2008.00322.x","article-title":"Treatment of diabetic rats with encapsulated islets","volume":"12","author":"Sweet IR","year":"2008","journal-title":"J Cell Mol Med"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/01.TP.0000155500.17348.94","article-title":"Treatment of streptozotocin-induced diabetes mellitus in rats by transplantation of islet cells from two major histocompatibility complex disparate rats in combination with intra bone marrow injection of allogeneic bone marrow cells","volume":"79","author":"Taira M","year":"2005","journal-title":"Transplantation","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1337","issn-type":"print"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/s001250051672","article-title":"C-peptide responses after meal challenge in mice transplanted with microencapsulated rat islets","volume":"44","author":"Tatarkiewicz K","year":"2001","journal-title":"Diabetologia","ISSN":"http:\/\/id.crossref.org\/issn\/0012-186X","issn-type":"print"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1021\/bc900494x","article-title":"Microencapsulation of islets with living cells using polyDNA-PEG-lipid conjugate","volume":"21","author":"Teramura Y","year":"2010","journal-title":"Bioconjug Chem","ISSN":"http:\/\/id.crossref.org\/issn\/1043-1802","issn-type":"print"},{"key":"ref55","series-title":"Current medical Diagnosis & Treatment. International edition","first-page":"1203","author":"Tierney LM","year":"2002"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1016\/j.transproceed.2010.05.100","article-title":"C5a-inhibitory peptide combined with gabexate mesilate prevents the instant blood-mediated inflammatory reaction in a rat model of islet transplantation","volume":"42","author":"Tokodai K","year":"2010","journal-title":"Transplant Proc","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1345","issn-type":"print"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/0140-6736(90)91946-8","article-title":"Pancreatic islet transplantation after upper abdominal exenteration and liver replacement","volume":"336","author":"Tzakis AG","year":"1990","journal-title":"Lancet","ISSN":"http:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1089\/ten.tea.2009.0286","article-title":"In vivo selection of biocompatible alginates for islet encapsulation and subcutaneous transplantation","volume":"16","author":"V\u00e9riter S","year":"2010","journal-title":"Tissue Eng Part A"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1749-6632.1999.tb08507.x","article-title":"Evaluation of graft-host response for various tissue sources and animal models","volume":"875","author":"Weber CJ","year":"1999","journal-title":"Ann N Y Acad Sci","ISSN":"http:\/\/id.crossref.org\/issn\/0077-8923","issn-type":"print"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2119\/molmed.2009.00099","article-title":"The synergistic effect of Tautomycetin on Cyclosporine A-mediated immunosuppression in a rodent islet allograft model","volume":"16","author":"Wee YM","year":"2010","journal-title":"Mol Med","ISSN":"http:\/\/id.crossref.org\/issn\/1076-1551","issn-type":"print"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.bbrc.2010.02.089","article-title":"The cytoprotection of chitosan based hydrogels in xenogeneic islet transplantation: an in vivo study in streptozotocin-induced diabetic mouse","volume":"393","author":"Yang KC","year":"2010","journal-title":"Biochem Biophys Res Commun","ISSN":"http:\/\/id.crossref.org\/issn\/0006-291X","issn-type":"print"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.jvs.2009.05.049","article-title":"Combination of stromal-derived factor-1alpha and vascular endothelial growth factor gene-modified endothelial progenitor cells is more effective for ischemic neovascularization","volume":"50","author":"Yu JX","year":"2009","journal-title":"J Vasc Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0741-5214","issn-type":"print"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1016\/j.biomaterials.2006.12.015","article-title":"Functional and histological evaluation of transplanted pancreatic islets immunoprotected by PEGylation and cyclosporine for 1 year","volume":"28","author":"Yun Lee D","year":"2007","journal-title":"Biomaterials","ISSN":"http:\/\/id.crossref.org\/issn\/0142-9612","issn-type":"print"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/jbm.a.32624","article-title":"The three-dimensional nanofiber scaffold culture condition improves viability and function of islets","volume":"94","author":"Zhao M","year":"2010","journal-title":"J Biomed Mater Res A"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1007\/s10856-005-0523-2","article-title":"Towards a medically approved technology for alginate-based microcapsules allowing long-term immunoisolated transplantation","volume":"16","author":"Zimmermann H","year":"2005","journal-title":"J Mater Sci Mater Med"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ag\/v48n2\/a11v48n2.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T20:46:39Z","timestamp":1712522799000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032011000200011&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0004-28032011000200011"],"URL":"https:\/\/doi.org\/10.1590\/s0004-28032011000200011","relation":{},"ISSN":["0004-2803"],"issn-type":[{"value":"0004-2803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}