{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:15:16Z","timestamp":1758636916128},"reference-count":20,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:p>CONTEXT: Most patients subjected to liver transplantation presents hypersplenism, which is reversed after the operation. However, some patients remain with moderate to intense hypersplenism. OBJECTIVES: To study the effect of liver transplantation on platelet count in patients with hypersplenism. METHOD: Of a total of 233 patients who underwent liver transplantation, 162 were excluded from the present study because of occurrence of steroid-resistant rejection, absence of hypersplenism before the transplantation, absence of follow-up for at least 2 years or incomplete exams data. The electronic study protocols of the remaining 71 patients were reviewed to determine the demographics, etiology of cirrhosis, and results of pathologic examination of the explanted liver. Serial platelet count was obtained from the study protocol on the day before liver transplantation and 1, 2, 4, and 6 months and 1 year after liver transplantation. Statistical analysis was performed using the Student's t-test, chi-square test, and Spearman's correlation test. RESULTS: Posttransplant platelet count at all time intervals was significantly higher than the pretransplant value (P&lt;0.001 for all time intervals). Thrombocytopenia was reversed (platelet count &gt;100,000\/mm\u00b3) in 58 patients (81.7%) 1 month after liver transplantation. Twelve patients (16.9%) remained with thrombocytopenia 1 year after liver transplantation. Three patients (4.2%) had recurrence of thrombocytopenia within 1 year after liver transplantation. There was no correlation between pretransplant platelet count and the Child-Pugh class or the MELD score. CONCLUSION: Liver transplantation reverses hypersplenism in most patients.<\/jats:p>","DOI":"10.1590\/s0004-28032011000300004","type":"journal-article","created":{"date-parts":[[2011,9,15]],"date-time":"2011-09-15T20:03:32Z","timestamp":1316117012000},"page":"175-178","source":"Crossref","is-referenced-by-count":7,"title":["Change in platelet count in patients with hypersplenism subjected to liver transplantation"],"prefix":"10.1590","volume":"48","author":[{"given":"J\u00falio Cezar Uili","family":"Coelho","sequence":"first","affiliation":[{"name":"Federal University of Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"Balbinot","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Nitsche","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00e1tia Aparecida","family":"Pinto","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f4nica Beatriz","family":"Parolin","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia Alexandra Pontes","family":"Ivantes","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/0016-5085(91)90293-T","article-title":"Reversal of hypersplenism after liver transplantation","volume":"100","author":"Aseni P","year":"1991","journal-title":"Gastroenterology","ISSN":"http:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1053\/jhep.2002.31352","article-title":"Change in portal flow after liver transplantation: effect on hepatic arterial resistance indices and role of spleen size","volume":"35","author":"Bolognesi M","year":"2002","journal-title":"Hepatology","ISSN":"http:\/\/id.crossref.org\/issn\/0161-0538","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.3748\/wjg.14.5723","article-title":"Severe thrombocytopenia before liver transplantation is associated with delayed recovery of thrombocytopenia regardless of donor type","volume":"14","author":"Chang JH","year":"2008","journal-title":"World J Gastroenterol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"317","DOI":"10.2214\/ajr.159.2.1632346","article-title":"Persistence of portosystemic collaterals and splenomegaly on CT after orthotopic liver transplantation","volume":"159","author":"Chezmar JL","year":"1992","journal-title":"AJR Am J Roentgenol","ISSN":"http:\/\/id.crossref.org\/issn\/0361-803X","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/s00268-009-0314-x","article-title":"Effect of liver transplantation on spleen size, collateral veins, and platelet counts","volume":"34","author":"Chikamori F","year":"2010","journal-title":"World J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0364-2313","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1097\/00007890-200212150-00026","article-title":"Effect of pediatric living-donor liver transplantation on splenomegaly","volume":"74","author":"Egami S","year":"2002","journal-title":"Transplantation","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1337","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1053\/gast.2002.32418","article-title":"The association between hepatitis C infection and survival after orthotopic liver transplantation","volume":"122","author":"Forman LM","year":"2002","journal-title":"Gastroenterology","ISSN":"http:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"s28","DOI":"10.1053\/jlts.2003.50248","article-title":"The natural history and outcome of liver transplantation in hepatitis C virus-infected recipients","volume":"9","author":"Gane E","year":"2003","journal-title":"Liver Transpl"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/lt.21694","article-title":"Treatment of hepatitis C in liver transplant recipients","volume":"15","author":"Gordon FD","year":"2009","journal-title":"Liver Transpl"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1016\/j.transproceed.2009.06.202","article-title":"Remission of splenic volume in the recipient during the course of adult-to-adult living donor liver transplantation: evaluation using multislice computed tomography and semiautomatic software","volume":"41","author":"Ishifuro M","year":"2009","journal-title":"Transplant Proc","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1345","issn-type":"print"},{"key":"ref11","first-page":"262","article-title":"Spleen volume and platelet number changes after living donor liver transplantation in adults","volume":"51","author":"Kaneko J","year":"2004","journal-title":"Hepatogastroenterology","ISSN":"http:\/\/id.crossref.org\/issn\/0172-6390","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/hep.510300112","article-title":"Systemic and splanchnic hemodynamic changes after liver transplantation for cirrhosis: a long-term prospective study","volume":"30","author":"Piscaglia F","year":"1999","journal-title":"Hepatology","ISSN":"http:\/\/id.crossref.org\/issn\/0161-0538","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0929-8266(97)00025-6","article-title":"Splenomegaly and hypersplenism in cirrhotic patients before and after orthotopic liver transplantation","volume":"6","author":"Pozzato C","year":"1997","journal-title":"Eur J Ultrasound","ISSN":"http:\/\/id.crossref.org\/issn\/0929-8266","issn-type":"print"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/hep.510290122","article-title":"High incidence of allograft cirrhosis in hepatitis C virus genotype 1b infection following transplantation: relationship with rejection episodes","volume":"29","author":"Prieto M","year":"1999","journal-title":"Hepatology","ISSN":"http:\/\/id.crossref.org\/issn\/0161-0538","issn-type":"print"},{"key":"ref15","first-page":"2580","article-title":"Measurement of spleen size and its relation to hypersplenism and portal hemodynamics in portal hypertension due to hepatic cirrhosis","volume":"91","author":"Shah SH","year":"1996","journal-title":"Am J Gastroenterol","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9270","issn-type":"print"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5010","DOI":"10.3748\/wjg.15.5010","article-title":"Treatment modalities for hypersplenism in liver transplant recipients with recurrent hepatitis C","volume":"15","author":"Sibulesky L","year":"2009","journal-title":"World J Gastroenterol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/0002-9610(82)90554-2","article-title":"Effect of operations for variceal hemorrhage on hypersplenism","volume":"144","author":"Soper NJ","year":"1982","journal-title":"Am J Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0002-9610","issn-type":"print"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3199","DOI":"10.1016\/j.transproceed.2007.08.105","article-title":"Spleen size changes in pediatric liver transplant recipients with functioning grafts","volume":"39","author":"Tutar NU","year":"2007","journal-title":"Transplant Proc","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1345","issn-type":"print"},{"key":"ref19","first-page":"1987","article-title":"Impact of liver transplantation on the reversal of hypersplenism","volume":"25","author":"Witte M","year":"1993","journal-title":"Transplant Proc","ISSN":"http:\/\/id.crossref.org\/issn\/0041-1345","issn-type":"print"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/00000658-198908000-00007","article-title":"Reversal of hypersplenism following orthotopic liver transplantation","volume":"210","author":"Yanaga K","year":"1989","journal-title":"Ann Surg","ISSN":"http:\/\/id.crossref.org\/issn\/0003-4932","issn-type":"print"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ag\/v48n3\/a04v48n3.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T23:58:21Z","timestamp":1495843101000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032011000300004&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,9]]}},"alternative-id":["S0004-28032011000300004"],"URL":"https:\/\/doi.org\/10.1590\/s0004-28032011000300004","relation":{},"ISSN":["0004-2803"],"issn-type":[{"value":"0004-2803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9]]}}}