{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:36:06Z","timestamp":1758638166384},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:p>CONTEXT: Hepatitis C is an important cause of chronic liver disease worldwide. The grading of hepatic fibrosis in chronic hepatitis C is important for better clinical management. However, until now, liver biopsy is the only test accepted for this purpose, despite their contraindications and complications. New methods for non-invasive assessment of hepatic fibrosis are under investigation. One proposal is the Doppler ultrasound, as a non-invasive, widely available and inexpensive. OBJECTIVE: To compare Doppler parameters of portal vein in patients with chronic hepatitis C with a healthy control group and to correlate these parameters with fibrosis degree obtained by liver biopsy. METHODS: Fifty patients with chronic hepatitis C submitted to liver biopsy and 44 healthy controls had Doppler of the portal vein performed, with the calculation of the portal venous index. We conducted a comparison between the averages of the two groups of portal venous index. For the correlation between portal venous index and fibrosis was employed the Spearman test. RESULTS: There was a difference between the average portal venous index between controls (0.33 \u00b1 0.07) and patients (0.23 \u00b1 0.09) with P&lt;0.001. No difference was observed between the portal venous index in patients with chronic hepatitis C who have significant fibrosis or not. The correlation between the portal venous index and fibrosis degree was reverse and moderate (r =-0.448 P&lt;0.001). The area under the ROC curve was 78.4% (95% CI: 68.8% to 88%). The cutoff for the portal venous index was 0.28 with sensitivity of 73.5% and specificity of 71.1%. CONCLUSION: The portal venous index was useful in distinguishing healthy patients from patients with CHC. However, there was no significant difference in the quantification of degree of fibrosis.<\/jats:p>","DOI":"10.1590\/s0004-28032012000100004","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T16:31:31Z","timestamp":1490977891000},"page":"14-18","source":"Crossref","is-referenced-by-count":6,"title":["Assessment of portal venous index as a non-invasive method for diagnosing liver fibrosis in patients with chronic hepatitis C"],"prefix":"10.1590","volume":"49","author":[{"given":"Haroldo Luis Oliva Gomes","family":"Rocha","sequence":"first","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang\u00e9lica Lemos Debs","family":"Diniz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9ria Ferreira de Almeida e","family":"Borges","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederico Chaves","family":"Salom\u00e3o","sequence":"additional","affiliation":[{"name":"UFU,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/jcu.20440","article-title":"Effects of diffuse fatty infiltration of the liver on portal vein flow hemodynamics","volume":"36","author":"Balci A","year":"2008","journal-title":"J Clin Ultrasound","ISSN":"http:\/\/id.crossref.org\/issn\/0091-2751","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1259\/bjr.75.893.750417","article-title":"Portal vein pulsatility and spectral width changes in patients with portal hypertension: relation to the severity of liver disease","volume":"75","author":"Barakat M","year":"2002","journal-title":"Br J Radiol","ISSN":"http:\/\/id.crossref.org\/issn\/0007-1285","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hep.510240201","article-title":"An algorithm for the grading of activity in chronic hepatitis C: The METAVIR Cooperative Study Group","volume":"24","author":"Bedossa P","year":"1996","journal-title":"Hepatology","ISSN":"http:\/\/id.crossref.org\/issn\/0270-9139","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.hep.2003.09.022","article-title":"Sampling variability of liver fibrosis in chronic hepatitis C","volume":"38","author":"Bedossa P","year":"2003","journal-title":"Hepatology","ISSN":"http:\/\/id.crossref.org\/issn\/0270-9139","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/00042737-200204000-00008","article-title":"Doppler measurements: a surrogate marker of liver fibrosis?","volume":"14","author":"Bernatik T","year":"2002","journal-title":"Eur J Gastroenterol Hepatol","ISSN":"http:\/\/id.crossref.org\/issn\/0954-691X","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0100-39842011000100005","article-title":"Dopplerfluxometria da veia hep\u00e1tica em pacientes com esteatose hep\u00e1tica n\u00e3o alco\u00f3lica","volume":"44","author":"Borges VFA","year":"2011","journal-title":"Radiol Bras","ISSN":"http:\/\/id.crossref.org\/issn\/0100-3984","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1365-2893.2006.00811.x","article-title":"Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases","volume":"14","author":"Coco B","year":"2007","journal-title":"J Viral Hepat","ISSN":"http:\/\/id.crossref.org\/issn\/1352-0504","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"833","DOI":"10.2214\/ajr.162.4.8141001","article-title":"Abnormalities of Doppler waveform of the hepatic veins in patients with chronic liver disease: correlation with histologic findings","volume":"162","author":"Colli A","year":"1994","journal-title":"AJR Am J Roentgenol","ISSN":"http:\/\/id.crossref.org\/issn\/0361-803X","issn-type":"print"},{"key":"ref9","first-page":"446","article-title":"Consensus of the Brazilian Society of Infectious Diseases on the management and treatment of hepatitis C","volume":"11","author":"de Ara\u00fajo ES","year":"2007","journal-title":"Braz J Infect Dis","ISSN":"http:\/\/id.crossref.org\/issn\/1413-8670","issn-type":"print"},{"key":"ref10","series-title":"Fatty liver disease: NASH and related disorders","first-page":"1","author":"Farrell GC","year":"2005"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2214\/ajr.169.1.9207514","article-title":"Flow pulsatility in the portal venous system: a study of Doppler sonography in healthy adults","volume":"169","author":"Gallix BP","year":"1997","journal-title":"AJR Am J Roentgenol","ISSN":"http:\/\/id.crossref.org\/issn\/0361-803X","issn-type":"print"},{"key":"ref12","first-page":"137","article-title":"Vis\u00e3o hist\u00f3rica e consenso nacional sobre a classifica\u00e7\u00e3o das hepatites cr\u00f4nicas - projeto do Clube de Patologia Hep\u00e1tica da Sociedade Brasileira de Patologia aprovado pela Sociedade Brasileira de Hepatologia","volume":"19","author":"Gayotto LCC","year":"2000","journal-title":"GED Gastroenterol Endosc Dig"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/0091270003258669","article-title":"Global burden of disease (GBD) for hepatitis C","volume":"44","year":"2004","journal-title":"J Clin Pharmacol","ISSN":"http:\/\/id.crossref.org\/issn\/0091-2700","issn-type":"print"},{"key":"ref14","first-page":"35","article-title":"Report of a WHO Consultation organized in collaboration with the Viral Hepatitis Prevention Board, Antwerp, Belgium","volume":"6","author":"Global surveillance and control of hepatitis C","year":"1999","journal-title":"J Viral Hepat","ISSN":"http:\/\/id.crossref.org\/issn\/1352-0504","issn-type":"print"},{"key":"ref15","first-page":"279","article-title":"Gray and color Doppler ultrasonography in differentiation between chronic viral hepatitis and compensated early stage cirrhosis","volume":"16","author":"Iliopoulos P","year":"2007","journal-title":"J Gastrointestin Liver Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1007\/s00330-004-2423-0","article-title":"Doppler waveform of the hepatic veins in an obese population","volume":"14","author":"Karabulut N","year":"2004","journal-title":"Eur Radiol","ISSN":"http:\/\/id.crossref.org\/issn\/0938-7994","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.2214\/ajr.184.6.01841848","article-title":"Can Doppler sonography grade the severity of hepatitis C-related liver disease?","volume":"184","author":"Lim AK","year":"2005","journal-title":"AJR Am J Roentgenol","ISSN":"http:\/\/id.crossref.org\/issn\/0361-803X","issn-type":"print"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0887-2171(02)90027-2","article-title":"Doppler in hepatic cirrhosis and chronic hepatitis","volume":"23","author":"Mart\u00ednez-Noguera A","year":"2002","journal-title":"Semin Ultrasound CT MR","ISSN":"http:\/\/id.crossref.org\/issn\/0887-2171","issn-type":"print"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1111\/j.1478-3231.2008.01900.x","article-title":"Noninvasive markers of liver fibrosis: playing the probabilities","volume":"28","author":"Myers RP","year":"2008","journal-title":"Liver Int"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.dld.2007.06.006","article-title":"Contrast-enhanced ultrasound to evaluate the severity of chronic hepatitis C","volume":"39","author":"Ridolfi F","year":"2007","journal-title":"Dig Liver Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1148\/radiol.10091295","article-title":"Liver fibrosis in chronic hepatitis C virus infection: differentiating minimal from intermediate fibrosis with perfusion CT","volume":"256","author":"Ronot M","year":"2010","journal-title":"Radiology","ISSN":"http:\/\/id.crossref.org\/issn\/0033-8419","issn-type":"print"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1440-1673.2008.01930.x","article-title":"Non-invasive prediction of the degree of liver fibrosis in patients with hepatitis C using an ultrasound contrast agent: A pilot study","volume":"52","author":"Searle J","year":"2008","journal-title":"J Med Imaging Radiat Oncol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1002\/hep.20119","article-title":"Diagnosis, management, and treatment of hepatitis C","volume":"39","author":"Strader DB","year":"2004","journal-title":"Hepatology","ISSN":"http:\/\/id.crossref.org\/issn\/0270-9139","issn-type":"print"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.7863\/jum.2002.21.9.1023","article-title":"Sonography of diffuse liver disease","volume":"21","author":"Tchelepi H","year":"2002","journal-title":"J Ultrasound Med","ISSN":"http:\/\/id.crossref.org\/issn\/0278-4297","issn-type":"print"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.cld.2006.08.012","article-title":"Hepatitis C virus and liver transplantation","volume":"10","author":"Verna EC","year":"2006","journal-title":"Clin Liver Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1023\/A:1026626505517","article-title":"Hepatic blood flow changes in chronic hepatitis C measured by duplex Doppler color sonography: relationship to histological features","volume":"43","author":"Walsh KM","year":"1998","journal-title":"Dig Dis Sci","ISSN":"http:\/\/id.crossref.org\/issn\/0163-2116","issn-type":"print"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ag\/v49n1\/04.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T19:58:06Z","timestamp":1495569486000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032012000100004&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0004-28032012000100004"],"URL":"https:\/\/doi.org\/10.1590\/s0004-28032012000100004","relation":{},"ISSN":["0004-2803"],"issn-type":[{"value":"0004-2803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3]]}}}