{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T10:04:07Z","timestamp":1725530647865},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>CONTEXT: Autoimmune diseases are 3 to 10 times more frequently in patients with celiac disease and their relatives than in the general population. OBJECTIVE: To investigate a broad spectrum of autoantibodies in celiac disease relatives from Southern Brazil, in a serological follow-up of 6-10 years, aiming to associate with other autoimmune diseases, degree of parentage, demographic and clinical data. METHODS: Serum samples of 233 relatives were analyzed in two different phases: n = 186 in phase I (1997-2000) and n = 138 (being 91 = follow-up group and 47 = newly tested) in phase II (2006-2007). As controls, 100 unrelated individuals were evaluated. Autoantibodies to smooth muscle, mitochondrial, liver-kidney microssome, parietal cell and thyroid microssome were tested by indirect immunofluorescence. RESULTS: A significant increase of autoantibodies, in both phases, was observed in the relatives when compared to the non-relatives (P = 0.0064), specifically to anti-thyroid microssome and anti-parietal cell. In both phases, the female\/male proportion of autoantibodies was of 4:1 to 3:1 (P&lt;0.041). The frequency of autoantibodies amongst 1st and 2nd degree relatives was 11.8% and 9.68% in phase I and 4% and 6.67% in phase II. CONCLUSION: Celiac disease relatives presented other autoantibodies and serological screening is a useful instrument for identifying autoimmune diseases along the years.<\/jats:p>","DOI":"10.1590\/s0004-28032012000300006","type":"journal-article","created":{"date-parts":[[2012,9,22]],"date-time":"2012-09-22T08:12:07Z","timestamp":1348301527000},"page":"199-203","source":"Crossref","is-referenced-by-count":4,"title":["Autoantibodies in relatives of celiac disease patients: a follow-up of 6-10 years"],"prefix":"10.1590","volume":"49","author":[{"given":"Fl\u00e1via Raphaela","family":"Nass","sequence":"first","affiliation":[{"name":"Federal University of Paran\u00e1"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorete Maria","family":"Kotze","sequence":"additional","affiliation":[{"name":"Catholic University of Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato 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