{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T07:07:04Z","timestamp":1777446424989,"version":"3.51.4"},"reference-count":16,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:p>CONTEXT - The first degree relatives of celiac patients represent a high risk group for the development of this disorder, so their screening may be crucial in the prevention of long-term complications. OBJECTIVE - In order to determine the prevalence of celiac disease in a group of first degree relatives of children with proven gluten intolerance, we conducted a prospective study that consisted in the screening of celiac disease, using a capillary immunoassay rapid test that allows a qualitative detection of IgA antibody to human recombinant tissue transglutaminase (IgA-TTG). METHODS - When the screening test was positive subjects were advised to proceed with further investigation. The screening test was performed in 268 first degree relatives (143 mothers, 89 fathers, 36 siblings) corresponding to 163 children with celiac disease. RESULTS - Screening test was positive in 12 relatives (4.5%), of which 1 refused to continue the investigation. In the remaining 11 relatives celiac disease was diagnosed in 7 cases (2.6%, 5 mothers, 2 fathers) who had a median age of 39 years (27-56 years), mild gastrointestinal symptoms, high titre of IgA-TTG and histology abnormalities confirming the diagnosis. All these patients are currently on a gluten-free diet. CONCLUSION - The prevalence of celiac disease among first degree relatives (2.6%) was 5 times higher than that in the general population. Although the recommendations for screening asymptomatic high risk groups, such as first degree relatives, are not unanimous the early diagnosis is crucial in preventing complications, including nutritional deficiency and cancer.<\/jats:p>","DOI":"10.1590\/s0004-28032012000300007","type":"journal-article","created":{"date-parts":[[2012,9,22]],"date-time":"2012-09-22T08:12:06Z","timestamp":1348301526000},"page":"204-207","source":"Crossref","is-referenced-by-count":14,"title":["Celiac disease in first degree relatives of celiac children"],"prefix":"10.1590","volume":"49","author":[{"given":"Andreia","family":"Oliveira","sequence":"first","affiliation":[{"name":"S\u00e3o Jo\u00e3o Hospital,  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunice","family":"Trindade","sequence":"additional","affiliation":[{"name":"S\u00e3o Jo\u00e3o Hospital,  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Tavares","sequence":"additional","affiliation":[{"name":"S\u00e3o Jo\u00e3o Hospital,  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Lima","sequence":"additional","affiliation":[{"name":"S\u00e3o Jo\u00e3o Hospital,  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Terra","sequence":"additional","affiliation":[{"name":"S\u00e3o Jo\u00e3o Hospital,  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Amil","family":"Dias","sequence":"additional","affiliation":[{"name":"S\u00e3o Jo\u00e3o Hospital,  Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1590\/S0004-28032008000100013","article-title":"Prevalence of celiac disease among first degree relatives of Brazilian celiac patients","volume":"45","author":"Almeida PL","year":"2008","journal-title":"Arq Gastroenterol","ISSN":"https:\/\/id.crossref.org\/issn\/0004-2803","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1097\/00005176-200202000-00027","article-title":"First study on the prevalence of celiac disease in a Portuguese population","volume":"34","author":"Antunes H","year":"2002","journal-title":"J Pediatric Gastroenterol Nutr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1097\/01.mpg.0000189337.08139.83","article-title":"Serologic and genetic markers of Celiac disease: a sequential study in the screening of first degree relatives","volume":"42","author":"Bonamico M","year":"2006","journal-title":"J Pediatr Gastroenterol Nutr","ISSN":"https:\/\/id.crossref.org\/issn\/0277-2116","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1136\/jcp.2004.023978","article-title":"Coeliac disease","volume":"58","author":"Corazza GR","year":"2005","journal-title":"J Clin Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9746","issn-type":"print"},{"key":"ref5","first-page":"8","article-title":"The prevalence of celiac disease among family members of celiac disease patients","volume":"116","author":"Dolinsek J","year":"2004","journal-title":"Wien Klin Wochenschr","ISSN":"https:\/\/id.crossref.org\/issn\/0043-5325","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1136\/gut.2006.095299","article-title":"Spectrum of gluten-sensitive enteropathy in first-degree relatives of patients with coeliac disease: clinical relevance of lymphocytic enteritis","volume":"55","author":"Esteve M","year":"2006","journal-title":"Gut","ISSN":"https:\/\/id.crossref.org\/issn\/0017-5749","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1001\/archinte.163.3.286","article-title":"Prevalence of celiac disease in at-risk and not-at-risk groups in the United States","volume":"163","author":"Fasano A","year":"2003","journal-title":"Arch Intern Med","ISSN":"https:\/\/id.crossref.org\/issn\/0003-9926","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.3748\/wjg.v16.i15.1828","article-title":"Risk factors in familial forms of celiac disease","volume":"16","author":"Freeman HJ","year":"2010","journal-title":"World J Gastroenterol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.dld.2007.07.161","article-title":"Familial prevalence among first-degree relatives of celiac disease in North India","volume":"39","author":"Grover R","year":"2007","journal-title":"Dig Liver Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005176-200501000-00001","article-title":"Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition","volume":"40","author":"Hill ID","year":"2005","journal-title":"J Pediatr Gastroenterol Nutr","ISSN":"https:\/\/id.crossref.org\/issn\/0277-2116","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1136\/bmj.39405.472975.80","article-title":"Population screening for coeliac disease in primary care by district nurses using a rapid antibody test: diagnostic accuracy and feasibility study","volume":"335","author":"Korponay-Szab\u00f3 IR","year":"2007","journal-title":"BMJ","ISSN":"https:\/\/id.crossref.org\/issn\/0959-8138","issn-type":"print"},{"key":"ref12","first-page":"62","article-title":"Doen\u00e7a cel\u00edaca: revis\u00e3o de conceitos e novos desenvolvimentos","volume":"16","author":"Pedro N","year":"2009","journal-title":"Rev Port Med Int"},{"key":"ref13","first-page":"184","article-title":"Doen\u00e7a cel\u00edaca revisitada","volume":"14","author":"Rito Nobre S","year":"2007","journal-title":"J Port Gastrenterol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1053\/j.gastro.2009.03.059","article-title":"Increased prevalence and mortality in undiagnosed celiac disease","volume":"137","author":"Rubio-Tapia A","year":"2009","journal-title":"Gastroenterology","ISSN":"https:\/\/id.crossref.org\/issn\/0016-5085","issn-type":"print"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1440-1746.2009.06044.x","article-title":"Prevalence, human leukocyte antigen typing and strategy for screening among Asian first-degree relatives of children with celiac disease","volume":"25","author":"Srivastava A","year":"2010","journal-title":"J Gastroenterol Hepatol","ISSN":"https:\/\/id.crossref.org\/issn\/0815-9319","issn-type":"print"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/00005176-199410000-00008","article-title":"Use of serological markers as a screening test in family members of patients with celiac disease","volume":"19","author":"Vitoria JC","year":"1994","journal-title":"J Pediatr Gastroenterol Nutr","ISSN":"https:\/\/id.crossref.org\/issn\/0277-2116","issn-type":"print"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ag\/v49n3\/v49n3a07.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T09:31:11Z","timestamp":1495877471000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032012000300007&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0004-28032012000300007"],"URL":"https:\/\/doi.org\/10.1590\/s0004-28032012000300007","relation":{},"ISSN":["0004-2803"],"issn-type":[{"value":"0004-2803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}