{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:35:19Z","timestamp":1793104519533,"version":"4.5.0"},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p> Context Functional dyspepsia represents a frequent gastrointestinal disorder in clinical practice. According to the Roma III criteria, functional dyspepsia can be classified into two types as the predominant sympton: epigastric pain and postprandial discomfort. Even though the pathophysiology is still uncertain, the functional dyspepsia seems to be related to multiple mechanisms, among them visceral hypersensitivity, changes in the gastroduodenal motility and gastric accommodation and psychological factors.   Objective Evaluate the effectiveness of acupuncture as a complementary to conventional treatment in functional dyspepsia patients.   Methods Randomized clinical trial in which were enrolled patients with functional dyspepsia patients in according with Rome III criteria. One group was submitted to drug therapy and specific acupuncture (GI) and the other to drug therapy and non-specific acupuncture (GII). The gastrointestinal symptoms, presence of psychiatric disorders and quality of life were evaluated, at the end and three months after treatment.   Results After 4 weeks of treatment there was improvement of gastrointestinal symptoms in Group I (55 \u00b1 12 vs 29 \u00b1 8.8; P = 0.001) and Group II (50.5 \u00b1 10.2 vs 46 \u00b1 10.5; P = 0.001). Quality of life was significantly better in Group I than group II (93.4 \u00b1 7.3 vs 102.4 \u00b1 5.1; P = 0.001). Anxiety (93.3% vs 0%; P = 0.001) and depression (46.7% vs 0%; P = 0.004) were significantly lower in Group I than group II. When comparing the two groups after 4 weeks of treatment, gastrointestinal symptoms (29 \u00b1 8.8 vs 46 \u00b1 10.5; P&lt;0.001) and quality of life (102.4 \u00b1 5.1 vs 96 \u00b1 6.1; P = 0.021) were significantly better in Group I than group II. Three months after the treatment, gastrointestinal symptoms remained better only in Group I, when compared to the pre-treatment values (38 \u00b1 11.3 vs 55 \u00b1 12; P = 0.001).   Conclusion In patients with functional dyspepsia the complementary acupuncture treatment is superior to conventional treatment. Further studies with more patients are needed to confirm these findings.<\/jats:p>","DOI":"10.1590\/s0004-28032013000200036","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T13:42:03Z","timestamp":1389706923000},"page":"202-207","source":"Crossref","is-referenced-by-count":28,"title":["ACUPUNCTURE EFFECTIVENESS AS A COMPLEMENTARY THERAPY IN FUNCTIONAL DYSPEPSIA PATIENTS"],"prefix":"10.1590","volume":"50","author":[{"given":"Flavia Altaf da Rocha","family":"LIMA","sequence":"first","affiliation":[{"name":"Universidade Federal de Juiz de Fora,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lincoln Eduardo Villela Vieira de Castro","family":"FERREIRA","sequence":"additional","affiliation":[{"name":"Universidade Federal de Juiz de Fora,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio Heleno de Lima","family":"PACE","sequence":"additional","affiliation":[{"name":"Universidade Federal de Juiz de Fora,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","first-page":"73","article-title":"Acupuncture modulates temporal neural responses in wide brain networks: evidence from fMRI study","volume":"6","author":"Bai L","year":"2010","journal-title":"Mol Pain"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.gtc.2010.08.005","article-title":"Current medical treatments of dyspepsia and irritable bowel syndrome","volume":"39","author":"Camilleri M","year":"2010","journal-title":"Gastroenterol Clin North Am"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1097\/00007611-199812000-00005","article-title":"Acupuncture: a review of its history, theories, and indications","volume":"91","author":"Ceniceros S","year":"1998","journal-title":"South Med J"},{"key":"ref4","series-title":"Valida\u00e7\u00e3o do question\u00e1rio de qualidade de vida \u00e2\u20ac\u0153medical outcomes study 36\u00e2\u20ac\ufffd \u00e2\u20ac\u201c item short \u00e2\u20ac\u201c form health survey (SF-36). [dissertation]","author":"Ciconelli RM","year":"1997"},{"key":"ref5","series-title":"Atlas de acupuntura, com sequencia de fotos, ilustra\u00e7\u00f5es, textos did\u00e1ticos e ilustra\u00e7\u00f5es cl\u00ednicas","author":"Focks C","year":"2005"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/MCG.0b013e3181c64c69","article-title":"Clinical practice: diagnosis and evaluation of dyspepsia","volume":"44","author":"Graham DY","year":"2010","journal-title":"J Clin Gastroenterol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/(SICI)1097-0193(2000)9:1<13::AID-HBM2>3.0.CO;2-F","article-title":"Acupuncture modulates the limbic system and subcortical gray structures of the human brain: evidence from fMRI studies in normal subjects","volume":"9","author":"Hui KK","year":"2000","journal-title":"Hum Brain Mapp"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1472-6882-7-33","article-title":"Characterization of the \u00e2\u20ac\u0153deqi\u00e2\u20ac\ufffd response in acupuncture","volume":"7","author":"Hui KK","year":"2007","journal-title":"BMC Complement Altern Med"},{"key":"ref9","first-page":"1527","article-title":"Electrical stimulation of acupuncture points enhances gastric myoelectrical activity in humans","volume":"92","author":"Lin X","year":"1997","journal-title":"Am J Gastroenterol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1365-2036.2011.04979.x","article-title":"Randomised clinical trial: an assessment of acupuncture on specific meridian or specific acupoint vs. sham acupuncture for treating functional dyspepsia","volume":"35","author":"Ma TT","year":"2012","journal-title":"Aliment Pharmacol Ther"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1054\/caom.2001.0114","article-title":"Standards for reporting interventions in controlled trials of acupuncture: the STRICTA recommendations","volume":"3","author":"MacPherson H","year":"2002","journal-title":"Clin Acupunct Oriental Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.autneu.2010.03.020","article-title":"Neurotrophins and acupuncture","volume":"157","author":"Manni L","year":"2010","journal-title":"Auton Neurosci"},{"key":"ref13","first-page":"52","article-title":"Hospital Anxiety and Depression Scale: a study on the validation of the criteria and reliability on preoperative patients","volume":"57","author":"Marcolino JA","year":"2007","journal-title":"Rev Bras Anestesiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/ecam\/nem077","article-title":"Mechanism of reflex regulation of the gastroduodenal function by acupuncture","volume":"5","author":"Noguchi E","year":"2008","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/aim.25.1-2.1","article-title":"Acupuncture for anxiety and anxiety disorders--a systematic literature review","volume":"25","author":"Pilkington K","year":"2007","journal-title":"Acupunct Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.autneu.2010.04.002","article-title":"Anxiety, depression and acupuncture: A review of the clinical research","volume":"157","author":"Pilkington K","year":"2010","journal-title":"Auton Neurosci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1365-2982.2004.00504.x","article-title":"Effects of electroacupuncture on gastric myoelectrical activity in healthy humans","volume":"16","author":"Shiotani A","year":"2004","journal-title":"Neurogastroenterol Motil"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1136\/aim.2009.000497","article-title":"Acupuncture for dyspepsia in pregnancy: a prospective, randomised, controlled study","volume":"27","author":"Silva JB","year":"2009","journal-title":"Acupunct Med"},{"key":"ref19","first-page":"293","article-title":"Functional dyspepsia and depression as an associated factor","volume":"43","author":"Silva RA","year":"2006","journal-title":"Arq Gastroenterol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1111\/j.1572-0241.2004.30086.x","article-title":"A systematic review of psychological therapies for nonulcer dyspepsia","volume":"99","author":"Soo S","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1155\/2001\/367832","article-title":"The updated Sydney system: classification and grading of gastritis as the basis of diagnosis and treatment","volume":"15","author":"Stolte M","year":"2001","journal-title":"Can J Gastroenterol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF01535722","article-title":"GSRS \u00e2\u20ac\u201c a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease","volume":"33","author":"Svedlund J","year":"1988","journal-title":"Dig Dis Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1136\/gut.44.1.55","article-title":"Gastric accommodation in non-ulcer dyspepsia and the roles of Helicobacter pylori infection and vagal function","volume":"44","author":"Thumshirn M","year":"1999","journal-title":"Gut"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1054\/ctim.2001.0489","article-title":"Clinical trials of acupuncture: consensus recommendations for optimal treatment, sham controls and blinding","volume":"9","author":"White AR","year":"2001","journal-title":"Complement Ther Med"},{"key":"ref25","series-title":"A arte de inserir","author":"Yamamura Y","year":"2001","edition":"2a ed"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.autneu.2010.03.007","article-title":"Gastrointestinal motility disorders and acupuncture","volume":"157","author":"Yin J","year":"2010","journal-title":"Auton Neurosci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ajg.2012.53","article-title":"Influence of acupuncture treatment on cerebral activity in functional dyspepsia patients and its relationship with efficacy","volume":"107","author":"Zeng F","year":"2012","journal-title":"Am J Gastroenterol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.pneurobio.2008.05.004","article-title":"Neural mechanism underlying acupuncture analgesia","volume":"85","author":"Zhao ZQ","year":"2008","journal-title":"Prog Neurobiol"}],"container-title":["Arquivos de 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