{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:18:05Z","timestamp":1761513485164},"reference-count":44,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>Context Pancreaticoduodenectomy is the procedure of choice for resectable cancer of the periampullary region. These tumors account for 4% of deaths from cancer, being referred to as one of the lowest survival rates at 5 years. Surgery remains a complex procedure with substantial morbidity and mortality. Despite reports of up to 30% mortality rates, in centers of excellence it have been identified as less than 5%. Recent studies show that pancreaticojejunostomy represents the \u201cAchilles\u2019 heel\u201d of the procedure. Objective To evaluate the post-operative 30 days morbidity and mortality rates. Methods Retrospective analysis of 97 consecutive resected patients between July, 2000 and December, 2012. All patients were managed by the same group, and data were obtained from specific database service. The main objective was to evaluate the 30-day mortality rate, but we also studied data of surgical specimen, need for vascular resection and postoperative complications (gastric stasis, pancreatic fistula, pneumonia and reoperation rate). Results Thirty-day mortality rate was 2.1% (two patients). Complete resection with no microscopic residual tumor was obtained in 93.8% of patients, and in 67.3% of cases pathology did not detected metastatic nodes. Among postoperative complications were reported 6% of prolonged gastric stasis, 10.3% of pneumonia, 10.3% of pancreatic fistula and 1% of infection in the drain pathway. Two patients underwent reoperation due to bleeding and infected hematoma caused by pancreatic fistula, and another for intestinal obstruction because of adhesions at postoperative day 12. Conclusions The pancreaticoduodenectomy as treatment procedure for periampullary cancers has a low morbidity and mortality rate in services with experience in Hepato-Pancreato-Biliary surgery, remaining as first-line treatment in resectable patients.<\/jats:p>","DOI":"10.1590\/s0004-28032014000100007","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T08:40:13Z","timestamp":1404290413000},"page":"29-33","source":"Crossref","is-referenced-by-count":8,"title":["LOW MORTALITY RATE IN 97 CONSECUTIVE PANCREATICODUODENECTOMIES: the experience of a group"],"prefix":"10.1590","volume":"51","author":[{"given":"Paulo Roberto Ott","family":"FONTES","sequence":"first","affiliation":[{"name":"UFCSPA \u2013 Departamento de Cl\u00ednica Cir\u00fargica, Brasil; Transplante Hep\u00e1tico e P\u00e2ncreas da Santa Casa de Porto Alegre \u2013 UFCSPA, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio Luiz","family":"WAECHTER","sequence":"additional","affiliation":[{"name":"UFCSPA \u2013 Departamento de Cl\u00ednica Cir\u00fargica, Brasil; Transplante Hep\u00e1tico e P\u00e2ncreas da Santa Casa de Porto Alegre \u2013 UFCSPA, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"NECTOUX","sequence":"additional","affiliation":[{"name":"UFCSPA \u2013 Departamento de Cl\u00ednica Cir\u00fargica, Brasil; Transplante Hep\u00e1tico e P\u00e2ncreas da Santa Casa de Porto Alegre \u2013 UFCSPA, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Artur","family":"SAMPAIO","sequence":"additional","affiliation":[{"name":"UFCSPA \u2013 Departamento de Cl\u00ednica Cir\u00fargica, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uir\u00e1 Fernandes","family":"TEIXEIRA","sequence":"additional","affiliation":[{"name":"UFCSPA \u2013 Departamento de Cl\u00ednica Cir\u00fargica, Brasil; Transplante Hep\u00e1tico e P\u00e2ncreas da Santa Casa de Porto Alegre \u2013 UFCSPA, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz","family":"PEREIRA-LIMA","sequence":"additional","affiliation":[{"name":"UFCSPA \u2013 Departamento de Cl\u00ednica Cir\u00fargica, Brasil; Transplante Hep\u00e1tico e P\u00e2ncreas da Santa Casa de Porto Alegre \u2013 UFCSPA, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"211","article-title":"Proximal migration of transanastomotic pancreatic stent following pancreaticoduodenectomy and pancreaticojejunostomy","volume":"25","author":"Ammori BJ","year":"1990","journal-title":"Int J Pancreatol. 1999;25:211-5."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1072-7515(03)00331-4","article-title":"Zero mortality after 152 consecutive pancreaticoduodenectomies with pancreaticogastrostomy","volume":"197","author":"Aranha GV","year":"2003","journal-title":"J Am Coll Surg."},{"key":"ref3","first-page":"8","article-title":"International Study Group on Pancreatic Fistula Definition. International Study Group on Pancreatic Fistula Definition \u2013 Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery. 2005;138:8-13.","volume":"138","author":"Bassi C","year":"2005","journal-title":"Surgery"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0039-6060(03)00345-3","article-title":"Ducto-mucosa versus end-to-side pancreaticojejunostomy reconstruction after pancreaticoduodenectomy: results of a prospective randomized trial","volume":"134","author":"Bassi C","year":"2003","journal-title":"Surgery"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jamcollsurg.2008.12.031","article-title":"Type of Pancreaticojejunostomy after Pancreaticoduodenectomy Decrease Rate of Pancreatic Fistula? A Randomized, Prospective, Dual-Institution Trial.","volume":"208","author":"Berger AC","year":"2009","journal-title":"J Am Coll Surg."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0002-9610(00)00422-0","article-title":"Pancreaticojejunal stent migration resulting in \u2018\u2018bezoar ileus\u2019\u2019","volume":"180","author":"Biffl WL","year":"2000","journal-title":"Am J Surg."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jamcollsurg.2008.04.033","article-title":"Effect of hospital volume on margin status after pancreaticoduodenectomy for cancer","volume":"207","author":"Bilimoria KY","year":"2008","journal-title":"J Am Coll Surg."},{"key":"ref8","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0039-6060(99)70234-5","article-title":"Effect of hospital volume on in-hospital mortality with pancreaticoduodenectomy","volume":"125","author":"Birkmeyer JD","year":"1999","journal-title":"Surgery"},{"key":"ref9","article-title":"Prevention and management of pancreatic fistula","author":"Callery MP","year":"2008","journal-title":"J Gastrointestinal Surg."},{"key":"ref10","first-page":"430","article-title":"One hundred and forty-five consecutives pancreaticoduodenectomies without mortality","volume":"217","author":"Cameron JL","year":"1993","journal-title":"Ann Surg 1993; 217:430-8."},{"key":"ref11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/00000658-195107000-00009","article-title":"Radical pancreaticoduodenectomy: report of two autopsies performed five and four years after operation","volume":"134","author":"Child CG","year":"1951","journal-title":"Ann Surg."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"S104","DOI":"10.1016\/j.amjsurg.2007.05.014","article-title":"Standart resection of pancreatic cancer and chance of cure","volume":"194","author":"Erdmann J","year":"2007","journal-title":"Am J Surg."},{"key":"ref13","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1001\/archsurg.143.12.1166","article-title":"Improved survival following pancreaticoduodenectomy to treat adenocarcinoma of the pancreas \u2013 the influence of operative blood loss","volume":"143","author":"Kazanjian KK","year":"2008","journal-title":"Arch Surg."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s00534-007-1305-7","article-title":"Strategies for the treatment of invasive ductal carcinoma of the pancreas and how to achieve zero mortality for pancreaticoduodenectomy","volume":"15","author":"Kimura W","year":"2008","journal-title":"J Hepatobiliary Pancreat Surg."},{"key":"ref15","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00423-008-0324-4","article-title":"The challenge of pancreatic anastomosis","volume":"383","author":"Kleepies A","year":"2008","journal-title":"Langerbecks Arch Surg."},{"key":"ref16","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s10620-008-0354-3","article-title":"Diagnostic and therapeutic approach to pancreatic cancer-associated gastroparesis","volume":"54","author":"Leung J","year":"2009","journal-title":"Dig Dis Sci."},{"key":"ref17","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0016-5107(04)00160-9","article-title":"Complications of temporary pancreatic stent insertion for pancreaticojejunal anastomosis during pancreaticoduodenectomy","volume":"59","author":"Levy MJ","year":"2004","journal-title":"Gastrointest Endosc"},{"key":"ref18","first-page":"951","article-title":"Risk factors and outcomes in postpancreaticoduodenectomy pancreaticocutaneos fistula","volume":"8","author":"Lin JW","year":"2004","journal-title":"J Gastrointest Surg. 2004;8:951-9."},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00423-006-0096-7","article-title":"Therapeutic strategies for the management of delayed gastric emptying after pancreatic resection","volume":"392","author":"Lytras D","year":"2007","journal-title":"Langerbecks Arch Surg."},{"key":"ref20","first-page":"157","article-title":"The volume-outcome relationship: practice-makesperfect or selective-referral patterns?","volume":"22","author":"Luft S","year":"1987","journal-title":"Health Serv Res."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/bjs.5407","article-title":"Meta-analysis of pancreaticojejunostomy versus pancreaticogastrostomy reconstruction after pancreaticoduodenectomy","volume":"93","author":"McKay A","year":"2006","journal-title":"Br J Surg."},{"key":"ref22","first-page":"668","article-title":"Low-Dose Erythromycin Reduces Delayed Gastric Emptying and Improves Gastric Motility After Billroth I Pylorus-Preserving Pancreaticoduodenectomy","volume":"234","author":"Ohwada S","year":"2001","journal-title":"Ann Surg. 2001;234:668-74."},{"key":"ref23","first-page":"41","article-title":"Correlation analysis between post-pancreatoduodenectomy pancreatic fistula and pancreatic histology","volume":"39","author":"Pereira FL","year":"2012","journal-title":"Rev Col Bras Cir."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1097\/SLA.0b013e3181492c28","article-title":"External Drainage of Pancreatic Duct With a Stent to Reduce Leakage Rate of Pancreaticojejunostomy After Pancreaticoduodenectomy: A ProspectiveRandomized Trial","volume":"246","author":"Poon PRT","year":"2007","journal-title":"Ann Surg."},{"key":"ref25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.yasu.2008.03.013","article-title":"Decreasing the pancreatic leak rate after pancreaticoduodenectomy","volume":"42","author":"Poon PRT","year":"2008","journal-title":"Adv Surg."},{"key":"ref26","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jsurg.2007.03.002","article-title":"Late pancreaticojejunostomy stent migration and hepatic abscess after Whipple procedure","volume":"64","author":"Rezvani M","year":"2007","journal-title":"J Surg Educ."},{"key":"ref27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.gassur.2006.08.010","article-title":"Pancreatic cancer in the general population: improvements in survival over the last decade","volume":"10","author":"Riall TS","year":"2006","journal-title":"J Gastroint Surg."},{"key":"ref28","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1590\/S0100-69912006000600011","article-title":"Duodenopancreatectomia: avalia\u00e7\u00e3o dos resultados em 41 pacientes","volume":"33","author":"Rocha LCG","year":"2006","journal-title":"Rev Col Bras Cir."},{"key":"ref29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00000658-199901000-00005","article-title":"Stented versus nonstented pancreaticojejunostomy after pancreatoduodenectomy: a prospective study","volume":"229","author":"Roder JD","year":"1999","journal-title":"Ann Surg."},{"key":"ref30","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/MPA.0b013e318162cb53","article-title":"A New Guideline to Reduce Postoperative Morbidity After Pancreaticoduodenectomy","volume":"37","author":"Satoi S","year":"2008","journal-title":"Pancreas"},{"key":"ref31","first-page":"17","article-title":"A Meta-analysis on the Efficacy of Preoperative Biliary Drainage for Tumors Causing Obstructive Jaundice","volume":"236","author":"Sewnath ME","year":"2002","journal-title":"Ann Surg. 2002;236:17-27."},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1007\/s00268-005-0137-3","article-title":"Pancreatic Anastomoses after Pancreaticoduodenectomy: Do We Need Further Studies?","volume":"29","author":"Shrikhande SV","year":"2005","journal-title":"World J Surg."},{"key":"ref33","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/bjs.5368","article-title":"Systematic review of outcome of synchronous portal-superior mesenteric vein resection during pancreatectomy for cancer","volume":"93","author":"Siriwardana HPP","year":"2006","journal-title":"Br J Surg."},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s00268-005-0152-4","article-title":"No Mortality among 100 Consecutive pancreaticoduodenectomies in a Middle-volume Center","volume":"29","author":"Suzuki Y","year":"2005","journal-title":"World J Surg."},{"key":"ref35","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.ejso.2006.10.041","article-title":"Determinants of complications in pancreaticoduodenectomy","volume":"33","author":"Topal B","year":"2007","journal-title":"EJSO"},{"key":"ref36","first-page":"18","article-title":"Incidence, risk factors and treatment of pancreatic leakage after pancreaticoduodenectomy: drainage versus resection of the pancreatic remnant. J Am Coll Surg. 1997;185:18-24.","volume":"185","author":"van Berge Henegouven MI","year":"1997","journal-title":"J Am Coll Surg."},{"key":"ref37","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005444.pub2","article-title":"Preoperative biliary drainage for obstructive jaundice","author":"Wang Q","year":"2008","journal-title":"Cochrane Database Syst Rev."},{"key":"ref38","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00534-003-0863-6","article-title":"Current pancreatogastrointestinal anastomotic methods: results of a Japanese survey of 3109 patients","volume":"11","author":"Watanabe M","year":"2004","journal-title":"J Hepatobiliary Pancreat Surg."},{"key":"ref39","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.surg.2007.05.005","article-title":"Delayed gastric emptying (DGE) after pancreatic surgery: a suggested definition by the International Study Group of Pancreatic Surgery (ISGPS)","volume":"142","author":"Wente MN","year":"2007","journal-title":"Surgery"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.gassur.2006.08.018","article-title":"1423 pancreaticoduodenectomies for pancreatic cancer: a single institution experience","volume":"10","author":"Winter JM","year":"2006","journal-title":"J Gastroint Surg."},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jamcollsurg.2007.01.026","article-title":"Biochemical markers predict morbidity and mortality after pancreaticoduodenectom","volume":"204","author":"Winter JM","year":"2007","journal-title":"J Am Coll Surg."},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.gassur.2006.07.020","article-title":"Does pancreatic duct stenting decrease the rate of pancreatic fistula following pancreaticoduodenectomy? Results of a prospective randomized trial","volume":"10","author":"Winter JM","year":"2006","journal-title":"J Gastrointest Surg. 2006;10:1280-90."},{"key":"ref43","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/SLA.0b013e31815aab22","article-title":"Em bloc vascular resection for locally advanced pancreatic malignancies infiltrating major blood vessels: perioperative outcome and long-term survival in 136 patients","volume":"247","author":"Yekebas EF","year":"2008","journal-title":"Ann Surg."},{"key":"ref44","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/00000658-199510000-00014","article-title":"A prospective randomized trial of pancreaticogastrostomy versus pancreaticojejunostomy after pancreaticoduodenectomy","volume":"222","author":"Yeo CJ","year":"1995","journal-title":"Ann Surg."}],"container-title":["Arquivos de Gastroenterologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ag\/v51n1\/0004-2803-ag-51-01-00029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T09:18:22Z","timestamp":1649582302000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032014000100029&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["S0004-28032014000100029"],"URL":"https:\/\/doi.org\/10.1590\/s0004-28032014000100007","relation":{},"ISSN":["0004-2803"],"issn-type":[{"value":"0004-2803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}