{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:18:43Z","timestamp":1787023123377,"version":"build-2736575974"},"reference-count":37,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>ContextGastric mucosa-associated lymphoid tissue (MALT) lymphoma is clearly associated with Helicobacter pylori gastritis and can be cured with anti- H pylori therapy alone. The presence of t(11;18)(q21;q21) translocation is thought to predict a lower response rate to anti- H pylori treatment.ObjectivesTo study the presence of t(11;18)(q21;q21) genetic translocation and its clinical impact in low-grade gastric MALT lymphoma Brazilian patients.MethodsA consecutive series of eight patients with gastric MALT lymphoma were submitted to gastroscopy, endoscopic ultrasound, histopathological examination, H pylori search and RT-PCR-based methodology. All patients received anti-H pylori treatment. Eradicated patients were followed-up every 3-6 months for 2 years.ResultsEight patients were studied. All patients had tumor involvement restricted to the mucosa or submucosa and seven patients had low-grade gastric MALT lymphoma. All infected patients achieved H pylori eradication. Histological tumor regression was observed in 5\/7 (71%) of the low-grade gastric MALT lymphoma patients. The presence of t(11;18)(q21;q21) translocation was found in 4 (57%) of these patients; among them only two had histological tumor regression following H pylori eradication.ConclusionsRT-PCR is a feasible and efficient method to detect t(11;18)(q21;q21) translocation, being carried out in routine molecular biology laboratories. The early detection of such translocation can be very helpful for better targeting the therapy to be applied to gastric MALT lymphoma patients.<\/jats:p>","DOI":"10.1590\/s0004-28032014000200003","type":"journal-article","created":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T13:12:34Z","timestamp":1404738754000},"page":"84-89","source":"Crossref","is-referenced-by-count":10,"title":["HELICOBACTER PYLORI AND t(11;18)(q21;q21) TRANSLOCATION IN GASTRIC MALT LYMPHOMA"],"prefix":"10.1590","volume":"51","author":[{"given":"Karine Sampaio","family":"LIMA","sequence":"first","affiliation":[{"name":"Instituto Alfa de Gastroenterologia, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walton","family":"ALBUQUERQUE","sequence":"additional","affiliation":[{"name":"Instituto Alfa de Gastroenterologia, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor Nunes","family":"ARANTES","sequence":"additional","affiliation":[{"name":"Instituto Alfa de Gastroenterologia, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"DRUMMOND-LAGE","sequence":"additional","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas de Minas Gerais - FCMMG, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz Gonzaga Vaz","family":"COELHO","sequence":"additional","affiliation":[{"name":"Instituto Alfa de Gastroenterologia, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"4014","DOI":"10.1182\/blood.V95.12.4014","article-title":"Translocation t(11;18) absent in early gastric marginal zone B-cell lymphoma of MALT type responding to eradication of Helicobacter pylori infection","volume":"95","author":"Alpen B","year":"2009","journal-title":"Blood"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1023\/A:1008202303666","article-title":"t(11;18)(q21;q21) is the most common translocation in MALT lymphomas","volume":"8","author":"Auer IA","year":"1997","journal-title":"Ann Oncol"},{"key":"ref3","series-title":"Textbook of Gastroenterology","volume-title":"Tumors of the stomach","volume":"1","author":"Boland CR","year":"1995","edition":"2nd ed"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1182\/asheducation-2001.1.241","article-title":"MALT Lymphomas","author":"Cavalli F","year":"2001","journal-title":"Hematology Am Soc Hematol Educ Program"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1590\/S0100-879X1999001200007","article-title":"Application of isotopeselective non-dispersive infrared spectrometry for the evaluation of the 13C-urea breath test: comparison with three concordant methods","volume":"32","author":"Coelho LG","year":"1999","journal-title":"Braz J Med Biol Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1136\/gut.52.11.1656","article-title":"Proposal for a new histological grading system for post-treatment evaluation of gastric MALT lymphoma","volume":"52","author":"Copie-Bergman C","year":"2003","journal-title":"Gut"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s12185-008-0187-z","article-title":"BCL10 nuclear expression and t(11;18)(q21;q21) indicate nonresponsiveness to Helicobacter pylori eradication of Chinese primary gastric MALT lymphoma","volume":"88","author":"Dong G","year":"2008","journal-title":"Int J Hematol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3960\/jslrt.47.31","article-title":"MALT Lymphoma: recent advances in aetiology and molecular genetics","volume":"47","author":"Du MQ","year":"2007","journal-title":"J Clin Exp Hematopathol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1136\/gut.2006.096420","article-title":"Most patients with minimal histological residuals of gastric MALT lymphoma after successful eradication of Helicobacter pylori can be managed safely by a watch and wait strategy: experience from a large international series","volume":"56","author":"Fischbach W","year":"2007","journal-title":"Gut"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/gut.53.1.34","article-title":"Long term outcome of patients with gastric marginal zone B cell lymphoma of mucosa associated lymphoid tissue (MALT) following exclusive Helicobacter pylori eradication therapy: experience from a large prospective series","volume":"53","author":"Fischbach W","year":"2004","journal-title":"Gut"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/0046-8177(93)90235-9","article-title":"Gastric lymphoid follicles in Helicobacter pylori infection: frequency, distribution, and response to triple therapy","volume":"24","author":"Genta RM","year":"1993","journal-title":"Hum Pathol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0140-6736(93)91408-E","article-title":"he response of cells from low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue to Helicobacter pylori","volume":"342","author":"Hussell T","year":"1993","journal-title":"Lancet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/0046-8177(94)90060-4","article-title":"Gastrointestinal lymphoma","volume":"25","author":"Isaacson PG","year":"1994","journal-title":"Hum Pathol"},{"key":"ref14","series-title":"Extranodal lymphomas","author":"Isaacson PG","year":"1994"},{"key":"ref15","first-page":"68","article-title":"Detec\u00e7\u00e3o e caracteriza\u00e7\u00e3o da t(11;18)(q21;q21) no linfoma g\u00e1strico MALT: Resposta completa ap\u00f3s erradica\u00e7\u00e3o do HP em doentes com a transloca\u00e7\u00e3o","volume":"12","author":"Lage P","year":"2005","journal-title":"GE - J Port Gastrenterol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0140-6736(00)03571-6","article-title":"Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy","volume":"357","author":"Liu H","year":"2001","journal-title":"Lancet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1182\/blood.V98.4.1182","article-title":"T(11;18)(q21;q21) is associated with advanced mucosa-associated lymphoid tissue lymphoma that expresses nuclear BCL10","volume":"98","author":"Liu H","year":"2001","journal-title":"Blood"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1053\/gast.2002.33047","article-title":"T(11;18) is a marker for all stage gastric MALT lymphomas that will not respond toH. pylori eradication","volume":"122","author":"Liu H","year":"2002","journal-title":"Gastroenterology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1093\/annonc\/mdi277","article-title":"Long-term persistence of molecular disease after histological remission in low-grade gastric MALT lymphoma treated with H. pylori eradication. Lack of association with translocation t(11;18): a 10-year updated follow-up of a prospective study","volume":"16","author":"Montalban C","year":"2005","journal-title":"Ann Oncol"},{"key":"ref20","first-page":"218","article-title":"Klinische Stadieneinteilung der Nicht-Hodgkin lymphome","volume":"153","author":"Musshoff K","year":"1977","journal-title":"Strahlentherapie"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/jcp.56.1.36","article-title":"Chromosomal translocation t(11;18) (q21;q21) in gastrointestinal mucosa associated lymphoid tissue lymphoma","volume":"56","author":"Nakamura S","year":"2003","journal-title":"J Clin Pathol"},{"key":"ref22","first-page":"3944","article-title":"The t(11;18) (q21;q21) chromosome translocation is a frequent and specific aberration in low-grade but not high-grade malignant non-Hodgkin\u2019s lymphomas of the mucosa-associated lymphoid tissue (MALT\u2013) type","volume":"57","author":"Ott G","year":"1997","journal-title":"Cancer Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00004836-200009000-00018","article-title":"Helicobacter pylori eradication and remission of low-grade gastric mucosa-associated lymphoid tissue lymphoma","volume":"31","author":"Papa A","year":"2000","journal-title":"J Clin Gastroenterol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1056\/NEJM199405053301803","article-title":"Helicobacter pylori infection and gastric lymphoma","volume":"330","author":"Parsonnet J","year":"1994","journal-title":"N Engl J Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/0016-5085(92)91723-H","article-title":"Gastrointestinal malignant lymphomas of the mucosa associated lymphoid tissue. Factors relevant toprognosis","volume":"102","author":"Radaszkiewicz T","year":"1992","journal-title":"Gastroenterology"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1136\/gut.2010.224949","article-title":"EGILS consensus report. Gastric extranodal marginal zone B-cell lymphoma of MALT","volume":"60","author":"Ruskone-Fourmestraux A","year":"2011","journal-title":"Gut"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nrgastro.2010.58","article-title":"Gastric MALT lymphoma: a model of chronic inflammation-induced tumor development","volume":"7","author":"Sagaert X","year":"2010","journal-title":"Nature Reviews Gastroenterology & Hepatology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"88","DOI":"10.7326\/0003-4819-131-2-199907200-00003","article-title":"Antibiotic treatment of gastric lymphoma of mucosa-associated lymphoid tissue: an uncontrolled trial","volume":"131","author":"Steinbach G","year":"1999","journal-title":"Ann Intern Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1038\/sj.leu.2403501","article-title":"Variable frequencies of MALT lymphoma-associated genetic aberrations in MALT lymphomas of different sites","volume":"18","author":"Streubel B","year":"2004","journal-title":"Leukemia"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/j.1349-7006.2009.01128.x","article-title":"Translocation t(11;18)(q21;q21) in gastric B-cell lymphomas","volume":"100","author":"Toracchio S","year":"2009","journal-title":"Cancer Sci"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3640","DOI":"10.1182\/blood-2010-01-265157","article-title":"The t(14;18)(q32;q21)\/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)\/API2-MALT1 translocation in MALT lymphomas is not","volume":"115","author":"Tsai AG","year":"2010","journal-title":"Blood"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/0140-6736(91)92035-Z","article-title":"Helicobacter pylori associated gastritis and primary B-cell gastric lymphoma","volume":"338","author":"Wotherspoon AC","year":"1991","journal-title":"Lancet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0140-6736(93)91409-F","article-title":"Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of Helicobacter pylori","volume":"342","author":"Wotherspoon AC","year":"1993","journal-title":"Lancet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"8018","DOI":"10.1200\/JCO.2005.02.3903","article-title":"Long-term follow-up of gastric MALT lymphoma after Helicobacter pylori eradication","volume":"23","author":"Wundisch T","year":"2005","journal-title":"J Clin Oncol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3109\/00365528809091712","article-title":"Immune response of the gastric mucosa to Campylobacter pylori","volume":"142","author":"Wyatt JI","year":"1988","journal-title":"Scand J Gastroenterology Suppl"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1182\/blood-2002-11-3502","article-title":"Variable frequencies of t(11;18)(q21;q21) in MALT lymphomas of different sites: significant association with CagA strains of H pylori in gastric MALT lymphoma","volume":"102","author":"Ye H","year":"2003","journal-title":"Blood"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cgh.2009.07.017","article-title":"Effects of Helicobacter pylori eradication on early stage gastric mucosa\u2013associated lymphoid tissue lymphoma","volume":"8","author":"Zullo A","year":"2010","journal-title":"Clin Gastroenterol Hepatol"}],"container-title":["Arquivos de Gastroenterologia"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/ag\/v51n2\/0004-2803-ag-51-02-84.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T21:43:35Z","timestamp":1598046215000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-28032014000200084&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0004-28032014000200084"],"URL":"https:\/\/doi.org\/10.1590\/s0004-28032014000200003","relation":{},"ISSN":["0004-2803"],"issn-type":[{"value":"0004-2803","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}