{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:07:18Z","timestamp":1762866438955},"reference-count":46,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:p>ContextData from Asian populations about gender-related differences in Crohn\u2019s disease are few.ObjectivesThis study was to analyze the clinical characteristics between women and men affected by Crohn\u2019s disease.MethodsThis was a retrospective cohort study to analyze consecutive Crohn\u2019s disease patients from Jan 2000 to Dec 2012. Clinical and phenotypic characteristics and treatment outcomes were evaluated.Results79 patients (55 male and two of them with positive family history) were diagnosed with Crohn\u2019s disease. Ileocolonic disease and inflammatory lesion was the most dominant site of involvement and disease behavior respectively in both men and women. Apart from higher frequency of nausea (45.83 vs 23.64%, P 0.024) and lower body mass index (19.44 vs 22.03 kg\/m2, P 0.003) reported in women, no significant gender-related differences in clinical characteristics were observed. Women were more associated with delay use of immunosuppressive therapy (12 vs 36 months, P = 0.028), particularly for those aged less than 40 years old (85 vs 62.6%,P = 0.023). Cox proportional hazard regression analysis revealed that active smoking (HR, 4.679; 95% CI, 1.03-21.18) and delayed use of immunosuppressive therapy (HR, 4.13; 95% CI, 1.01-16.88) were only independent risk factors associated with increased risk of complications.ConclusionsThere were no significant gender-specific differences in clinical and phenotypic characteristics between male and female Crohn\u2019s disease patients. Smoking history and delay use of immunosuppressive therapy were associated with higher risk of complications.<\/jats:p>","DOI":"10.1590\/s0004-28032014000200004","type":"journal-article","created":{"date-parts":[[2014,7,7]],"date-time":"2014-07-07T17:12:47Z","timestamp":1404753167000},"page":"90-96","source":"Crossref","is-referenced-by-count":12,"title":["GENDER-RELATED DIFFERENCES IN CLINICAL COURSE OF CROHN\u2019S DISEASE IN AN ASIAN POPULATION: a retrospective cohort review"],"prefix":"10.1590","volume":"51","author":[{"given":"Siu-tong","family":"LAW","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kin Kong","family":"LI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1097\/01.MIB.0000160742.91602.b7","article-title":"Methods to avoid infections in patients with inflammatory bowel disease","volume":"11","author":"Aberra FN","year":"2005","journal-title":"Inflamm Bowel Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00535-009-0057-3","article-title":"Prevalence of ulcerative colitis and Crohn\u2019s disease in Japan","volume":"44","author":"Asakura K","year":"2009","journal-title":"J Gastroenterol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1111\/j.1365-2036.2009.04103.x","article-title":"High therapy adherence but substantial limitations to daily activities amongst members of the Dutch inflammatory bowel disease patients\u2019 organization: a patient empowerment study","volume":"8","author":"Baars JE","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1002\/art.1780381203","article-title":"Effects of immunosuppressive drugs during pregnancy","volume":"12","author":"Bermas BL","year":"1995","journal-title":"Arthritis Rheum"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.crohns.2010.12.012","article-title":"Female patients suffering from inflammatory bowel diseases are treated less frequently with immunosuppressive medication and have a higher disease activity: a subgroup analysis of a large multi-centre, prospective, internet-based study","volume":"5","author":"Blumenstein I","year":"2011","journal-title":"J Crohns Colitis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1365-2036.2007.03365.x","article-title":"Adherence to thiopurine treatment in out-patients with Crohn\u2019s disease","volume":"2","author":"Bokemeyer B","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"ref7","series-title":"Inflammatory bowel disease","first-page":"31","volume-title":"The epidemiology of idiopathic inflammatory bowel disease.","author":"Kirsner JB","year":"1995","edition":"4th ed"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1002\/ibd.20335","article-title":"Changes in Crohn\u2019s disease phenotype over time in the Chinese population: validation of the Montreal classification system","volume":"14","author":"Chow DK","year":"2008","journal-title":"Inflamm Bowel Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1007\/s10620-008-0469-6","article-title":"Crohn\u2019s disease in India: a multicenter study from a country where tuberculosis is endemic","volume":"54","author":"Das K","year":"2009","journal-title":"Dig Dis Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/j.1572-0241.2007.01212.x","article-title":"Predictors of medication adherence in inflammatory bowel disease","volume":"7","author":"Ediger JP","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/0016-5085(85)90006-X","article-title":"Long-term follow-up of patients with Crohn\u2019s disease. 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