{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T14:03:51Z","timestamp":1765807431580},"reference-count":27,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>Background Familial Mediterranean Fever and celiac disease are both related to auto-inflammation and\/or auto-immunity and they share some common clinical features such as abdominal pain, diarrhea, bloating and flatulence. Objectives We aimed to determine the association of these two diseases, if present. Methods Totally 112 patients diagnosed with Familial Mediterranean Fever and 32 cases as healthy control were included in the study. All participants were examined for the evidence of celiac disease, with serum tissue transglutaminase IgA levels (tTG IgA). Results Totally 144 cases, 112 with Familial Mediterranean Fever and 32 healthy control cases were included in the study. tTG IgA positivity was determined in three cases with Familial Mediterranean Fever and in one case in control group. In that aspect there was no significant difference regarding the tTG IgA positivity between groups (P=0.81). Duodenum biopsy was performed to the tTG IgA positive cases and revealed Marsh Type 3b in two Familial Mediterranean Fever cases and Marsh Type 3c in the other one while the biopsy results were of the only tTG IgA positive case in control group was Marsh Type 3b. In HLA evaluation of the celiac cases; HLA DQ2 was present in two celiac cases of the Familial Mediterranean Fever group and in the only celiac case of the control group while HLA DQ8 was present in one celiac case of the Familial Mediterranean Fever group. Conclusions We did not determine an association of Familial Mediterranean Fever with celiac disease. Larger studies with subgroup analysis are warranted to determine the relationship of these two diseases.<\/jats:p>","DOI":"10.1590\/s0004-28032015000100012","type":"journal-article","created":{"date-parts":[[2017,3,15]],"date-time":"2017-03-15T18:53:59Z","timestamp":1489604039000},"page":"55-58","source":"Crossref","is-referenced-by-count":4,"title":["THE PREVALENCE OF CELIAC DISEASE AMONG PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER"],"prefix":"10.1590","volume":"52","author":[{"given":"Sedat","family":"I\u015eIKAY","sequence":"first","affiliation":[{"name":"Gaziantep Children\u2019s Hospital, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurg\u00fcl","family":"I\u015eIKAY","sequence":"additional","affiliation":[{"name":"Gaziantep University, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halil","family":"KOCAMAZ","sequence":"additional","affiliation":[{"name":"Gaziantep Children\u2019s Hospital, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0092-8674(00)80539-5","article-title":"Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever","volume":"90","year":"1997","journal-title":"Cell"},{"issue":"2","key":"ref2","first-page":"183","article-title":"Type 1 diabetes mellitus associated with autoimmune thyroid disease, celiac disease and familial Mediterranean fever: case report","volume":"51","author":"Ba\u015f F","year":"2009","journal-title":"Turk J Pediatr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/BF01450901","article-title":"Coexistence of familial Mediterranean fever with sacroiliitis and Beh\u00e7et\u2019s disease: a rare occurrence","volume":"17","author":"Birlik M","year":"1998","journal-title":"Clin Rheumatol"},{"issue":"7337","key":"ref4","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature09849","article-title":"Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens","volume":"471","author":"DePaolo RW","year":"2011","journal-title":"Nature"},{"issue":"9673","key":"ref5","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/S0140-6736(09)60254-3","article-title":"Coeliac disease","volume":"373","author":"Di Sabatino A","year":"2009","journal-title":"Lancet"},{"issue":"4","key":"ref6","first-page":"489","article-title":"Hashimoto\u2019s thyroiditis in a child with familial Mediterranean fever: a case report","volume":"23","author":"Ergul AB","year":"2013","journal-title":"Iran J Pediatr"},{"issue":"2","key":"ref7","first-page":"93","article-title":"The clinical presentation of celiac disease: experiences from northeastern iran","volume":"6","author":"Ganji A","year":"2014","journal-title":"Middle East J Dig Dis"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/MPG.0b013e3181818fb9","article-title":"Celiac disease pathogenesis: The proinflammatory cytokine network","volume":"47","author":"Garrote JA","year":"2008","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.18388\/abp.2014_1897","article-title":"Graves\u2019 disease, celiac disease and liver function abnormalities in a patient - clinical manifestation and diagnostic difficulties","volume":"61","author":"G\u00f3ra-G\u0119bka M","year":"2014","journal-title":"Acta Biochim Pol"},{"issue":"32","key":"ref10","doi-asserted-by":"crossref","first-page":"13073","DOI":"10.1073\/pnas.1311861110","article-title":"Dietary gluten triggers concomitant activation of CD4+ and CD8+ \u03b1\u03b2 T cells and \u03b3\u03b4 T cells in celiac disease","volume":"110","author":"Han A","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref11","first-page":"143","article-title":"Autoinflammatory disorders: a new concept in hereditary periodic fever syndromes","volume":"21","author":"Horcada Rubio ML","year":"2004","journal-title":"An Med Interna"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s10875-008-9179-2","article-title":"Autoinflammatory diseases: mimics of autoimmunity or part of its spectrum? 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