{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T05:39:07Z","timestamp":1774330747111,"version":"3.50.1"},"reference-count":16,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>BackgroundLow bone mineral density is considered an extra-intestinal manifestation of celiac disease with reduced bone mass, increased bone fragility, and risk of fractures. Celiac disease is considered a condition at high risk for secondary osteoporosis and the evaluation of bone density is very important in the clinical management of these patients.ObjectiveThe present study aimed to investigate bone alterations in celiac patients from Curitiba, South Region of Brazil at diagnosis, correlating the findings with age and gender.MethodsPatients who were included in the study were attended to in a private office of the same physician from January 2009 to December 2013. The diagnosis of celiac disease was done through clinical, serological and histological findings. All data were collected from the medical charts of the patients. After the diagnosis of celiac disease, evaluation for low bone mineral density was requested by dual-energy X-ray absorptiometry (DEXA). DEXA bone densitometer was used to estimate low bone mineral density at the lumbar spine and femur.ResultsA total of 101 patients, 82 (81.2%) female and 19 (18.8%) male subjects, with mean age of 39.0\u00b13.03 years were included. At celiac disease diagnosis, 36 (35.6%) were younger than 30 years, 41 (40.6%) were between 31 and 50 years, and 24 (23.8%) were older than 50 years. Among the evaluated patients, 69 (68.3%) presented low bone mineral density, being 47% with osteopenia and 32% with osteoporosis. Patients who were older than 51 years and diagnosed with celiac disease presented low bone mineral density in 83.3% (20\/24) of the cases. As expected, age influenced significantly the low bone mineral density findings. Among women, low bone mineral density was present with high frequency (60%) from 30 to 50 years. In patients diagnosed older than 60 years (n=8), all the women (n=5) and two of the three men had osteoporosis.ConclusionThis study demonstrated that 69% of Brazilian patients with celiac disease at diagnosis had low bone mineral density, being more frequent in women older than 50 years.<\/jats:p>","DOI":"10.1590\/s0004-28032015000300004","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T13:07:32Z","timestamp":1444914452000},"page":"176-179","source":"Crossref","is-referenced-by-count":12,"title":["LOW BONE MINERAL DENSITY IN BRAZILIAN PATIENTS AT DIAGNOSIS OF CELIAC DISEASE"],"prefix":"10.1590","volume":"52","author":[{"given":"Joyce Timmermans Pires da","family":"SILVA","sequence":"first","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato M","family":"NISIHARA","sequence":"additional","affiliation":[{"name":"Universidade Positivo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds Roberto","family":"KOTZE","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia","family":"OLANDOSKI","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorete Maria da Silva","family":"KOTZE","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1136\/gut.35.9.1219","article-title":"Localization of vitamin D receptor in normal human duodenum and in patients with coeliac disease","volume":"9","author":"Colston KW","year":"1994","journal-title":"Gut"},{"issue":"5(11)","key":"ref2","doi-asserted-by":"crossref","first-page":"4786","DOI":"10.3390\/nu5114786","article-title":"Bone mass and mineral metabolism alterations in adult celiac disease: pathophysiology and clinical approach","volume":"22","author":"Di Stefano M","year":"2013","journal-title":"Nutrients"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1590\/0004-2730000002919","article-title":"Celiac disease screening in Brazilian patients with osteoporosis","volume":"58","author":"Gusso L","year":"2014","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"ref4","article-title":"Coeliac disease and bone fractures: a systematic review and meta-analysis","author":"Heikkil\u00e4 K","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/sj.ejcn.1602856","article-title":"A dietary survey to determine if patients with celiac disease are meeting current healthy eating guidelines and how their diet compares to that of the british general population","volume":"61","author":"Kinsey L","year":"2008","journal-title":"Eur. 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