{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:13:22Z","timestamp":1785798802369,"version":"3.56.0"},"reference-count":47,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:p>Background - Celiac disease is an immune-mediated enteropathy due to a permanent sensitivity to gluten in genetically susceptible people. Iron-deficiency anemia is the most widely experienced anemia in humans. Iron-deficiency anemia additionally is a common extra intestinal manifestation of celiac disease. Objective - To investigate correlation between tTg levels and histological alterations and then to determine the prevalence of celiac disease in Center and South area patients of Iran with iron deficiency anemia. Methods - A total of 402 patients aged 12-78 years who presented with iron-deficiency anemia were included in this study. Hemoglobin, mean corpuscular volume and serum ferritin were determined. Venous blood samples for anti-tissue transglutaminase antibody immunoglobuline A and G were obtained from these patients. Upper gastrointestinal endoscopy was recommended to patients who had positive serology. Results - Of 402 patients with iron-deficiency anemia, 42 (10.4%) had positive serology for celiac disease. The small intestine biopsy of all patients with positive serology showed pathological changes (Marsh I, II &amp; III). There was not significant difference in the mean hemoglobin level between iron-deficiency anemia patients with celiac disease and without celiac disease, duodenal biopsy results did not show significant relationship between the severity of pathological changes and levels of anti-tTG IgG (P -value: 0\/869) but significant relationship was discovered between pathological changes and levels of anti-tTG IgA (P -value: 0\/004). Conclusion - Screening of celiac disease by anti-tissue transglutaminase antibody should be completed as a routine investigation in patients with iron-deficiency anemia. Also physicians must consider celiac disease as a possible reason of anemia in all patients with iron deficiency anemia.<\/jats:p>","DOI":"10.1590\/s0004-28032015000400006","type":"journal-article","created":{"date-parts":[[2016,1,30]],"date-time":"2016-01-30T23:30:15Z","timestamp":1454196615000},"page":"278-282","source":"Crossref","is-referenced-by-count":13,"title":["THE PREVALENCE OF CELIAC DISEASE IN PATIENTS WITH IRON-DEFICIENCY ANEMIA IN CENTER AND SOUTH AREA OF IRAN"],"prefix":"10.1590","volume":"52","author":[{"given":"Mahmud","family":"BAGHBANIAN","sequence":"first","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"FARAHAT","sequence":"additional","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Ali","family":"VAHEDIAN","sequence":"additional","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"SHEYDA","sequence":"additional","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad Reza","family":"ZARE-KHORMIZI","sequence":"additional","affiliation":[{"name":"Shahid Sadoughi University of Medical Sciences, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.cgh.2006.02.010","article-title":"Utility in clinical practice of immunoglobulin a anti-tissue transglutaminase antibody for the diagnosis of celiac disease","volume":"4","author":"Abrams JA","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1097\/01.meg.0000224477.51428.32","article-title":"Screening of the adult population in Iran for coeliac disease: comparison of the tissue-transglutaminase antibody and anti-endomysial antibody tests","volume":"18","author":"Akbari MR","year":"2006","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s12664-014-0464-0","article-title":"Clinical and histopathological correlation of duodenal biopsy with IgA anti-tissue transglutaminase titers in children with celiac disease","volume":"33","author":"Bhattacharya M","year":"2014","journal-title":"Indian Journal of Gastroenterology"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1590-8658(02)80197-9","article-title":"Clinical features of coeliac disease","volume":"34","author":"Biagi F","year":"2002","journal-title":"Dig Liver Dis"},{"issue":"3","key":"ref5","first-page":"691","article-title":"The clinical pattern of subclinical\/silent celiac disease: an analysis on 1026 consecutive cases","volume":"94","author":"Bottaro G","year":"1999","journal-title":"Am J Gastroenterol"},{"issue":"2","key":"ref6","first-page":"121","article-title":"Changing trends in clinical form of celiac disease","volume":"48","author":"Brandimarte G","year":"2002","journal-title":"Which is now the main form of celiac disease in clinical practice? 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