{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T05:20:56Z","timestamp":1777699256803,"version":"3.51.4"},"reference-count":41,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>ABSTRACT Background Recently, a great variety of studies aimed to investigate and even suggestHelicobacter pylori as an important key factor in gastrointestinal and non-gastrointestinal events development. The well-established relationship between bacterial virulence and increased risk for peptic ulcer or gastric carcinoma is not so clear when comparing inflammation markers alterations, such C-reactive protein, with the pathogen. Objective The objective of this study was to evaluate the presence of H. pylori, bacterial virulence and C-reactive protein serum levels in individuals diagnosed with functional dyspepsia. Methods Were prospectively included in this study 489 dyspeptic individuals. They fulfill Rome III clinical criteria for the diagnosis of functional dyspepsia with no organic disease at endoscopy. The bacterial infection was established by histology and urease rapid test. The levels of serum C-reactive protein were obtained by immunonefelometry and CagA status ofH. pylori positive individuals was determined through an imunoenzimatic assay. Results Prevalence rate of H. pylori was 66.3% and virulence factor CagA was detected in nearly 43% of positive samples. In addition, it has been noticed an association between Ilex paraguariensis(yerba mat\u00e9) consumption and pathogen's prevalence. An important effect of bacterial infection on inflammation was only observed in gastric epithelium. Conclusion No systemic response to the pathogen, measured through C-reactive protein levels, was observed, regardless of CagA status. Otherwise, the intake of yerba mat\u00e9 should be considered as a cultural factor possibly related toH. pylori's transmission.<\/jats:p>","DOI":"10.1590\/s0004-28032016000100010","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T01:08:24Z","timestamp":1459386504000},"page":"49-54","source":"Crossref","is-referenced-by-count":7,"title":["LACK OF ASSOCIATION BETWEEN HELICOBACTER PYLORI'S VIRULENCE AND INCREASED SERUM C-REACTIVE PROTEIN LEVELS IN FUNCTIONAL DYSPEPTIC PATIENTS"],"prefix":"10.1590","volume":"53","author":[{"given":"Huander Felipe","family":"ANDREOLLA","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura Renata de","family":"BONA","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme Becker","family":"SANDER","sequence":"additional","affiliation":[{"name":"Hospital Ernesto Dornelles, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Edmundo","family":"MAZZOLENI","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Brazil; Hospital de Cl\u00ednicas de Porto Alegre, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rejane Giacomelli","family":"TAVARES","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pelotas, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Carlos","family":"PROLLA","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio Grande do Sul, Brazil; Hospital de Cl\u00ednicas de Porto Alegre, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1161\/01.STR.32.2.385","article-title":"Detection of Helicobacter pylori in human carotid atherosclerotic plaques","volume":"32","author":"Ameriso SF","year":"2001","journal-title":"Stroke"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1746-6342.2006.00026.x","article-title":"Changes in biochemical parameters related to atherosclerosis after Helicobacter pylori eradication","volume":"2","author":"Ando T","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1478-811X-9-28","article-title":"Molecular mechanisms of gastric epithelial cell adhesion and injection of CagA by Helicobacter pylori","volume":"9","author":"Backert S","year":"2011","journal-title":"Cell Commun Signal"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0021-9150(99)00210-5","article-title":"Chronic infection with Helicobacter pylori does not provoke major systemic inflammation in healthy adults: results from a large population-based study","volume":"147","author":"Brenner H","year":"1999","journal-title":"Atherosclerosis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.4330\/wjc.v7.i4.187","article-title":"Helicobacter pylori vs coronary heart disease - searching for connections","volume":"7","author":"Chmiela M","year":"2015","journal-title":"World J Cardiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1590\/S1517-83822010000200007","article-title":"Anti-Helicobacter pylori activity of plant extracts traditionally used for the treatment of gastrointestinal disorders","volume":"41","author":"Cogo LL","year":"2010","journal-title":"Braz. 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