{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:18:41Z","timestamp":1787023121655,"version":"build-2736575974"},"reference-count":36,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Gastroenterol."],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>ABSTRACT Background - Exposure to viral antigens that share amino acid sequence similar with self- antigens might trigger autoimmune diseases in genetically predisposed individuals, and the molecular mimicry theory suggests that epitope mimicry between the virus and human proteins can activate autoimmune disease. Objective - The purpose of this study is to explore the possible sequence similarity between the amino acid sequences of thyroid self-protein and hepatitis C virus proteins, using databanks of proteins and immunogenic peptides, to explain autoimmune thyroid disease. Methods - Were performed the comparisons between the amino acid sequence of the hepatitis C virus polyprotein and thyroid self-protein human, available in the database of National Center for Biotechnology Information on Basic Local Alignment Search Tool. Results - The sequence similarity was related each hepatitis C virus genotype to each thyroid antigen. The similarities between the thyroid and the viral peptides ranged from 21.0 % (31 identical residues out of 147 amino acid in the sequence) to 71.0% (5 identical residues out of 7 amino acid in the sequence). Conclusion - Bioinformatics data, suggest a possible pathogenic link between hepatitis C virus and autoimmune thyroid disease. Through of molecular mimicry is observed that sequences similarities between viral polyproteins and self-proteins thyroid could be a mechanism of induction of crossover immune response to self-antigens, with a breakdown of self-tolerance, resulting in autoimmune thyroid disease.<\/jats:p>","DOI":"10.1590\/s0004-28032016000300012","type":"journal-article","created":{"date-parts":[[2016,7,16]],"date-time":"2016-07-16T09:30:58Z","timestamp":1468661458000},"page":"185-191","source":"Crossref","is-referenced-by-count":13,"title":["SEQUENCE SIMILARITY BETWEEN THYROID SELF-PROTEIN AND HEPATITIS C VIRUS POLYPROTEIN: possible triggering mechanism of autoimmune thyroiditis"],"prefix":"10.1590","volume":"53","author":[{"given":"Maristella de Ara\u00fajo Carvalho","family":"SOUSA","sequence":"first","affiliation":[{"name":"Universidade Estadual de Santa Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymundo","family":"PARAN\u00c1","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu\u00eds Jesu\u00edno de Oliveira","family":"ANDRADE","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Santa Cruz, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul SF","year":"1990","journal-title":"J Mol Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1590\/S1413-86702011000400013","article-title":"Thyroid disorders in patients with chronic hepatitis C using interferon-alpha and ribavirin therapy","volume":"15","author":"Andrade 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