{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T10:26:47Z","timestamp":1648636007626},"reference-count":7,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[1963,9]]},"abstract":"<jats:p>Foi estudada a rela\u00e7\u00e3o entre as concentra\u00e7\u00f5es de 2-sulfaniIamido-5-metilpirimidina (SMP) no LCR e no sangue ap\u00f3s a administra\u00e7\u00e3o oral da droga a 30 pacientes. Do total, 19 apresentavam LCR normal e eram portadores de afec\u00e7\u00f5es cr\u00f4nicas n\u00e3o inflamat\u00f3rias do sistema nervoso. Nos restantes o LCR apresentava altera\u00e7\u00f5es de tipos diversos; 4 eram portadores de polirradiculoneurite; um, de meningite cr\u00f4nica; um, de neurolues; 5, de neurocisticercose. Os resultados referentes aos pacientes com LCR normal mostraram que h\u00e1 correla\u00e7\u00e3o estatisticamente significativa entre as taxas de SMP no LCR e no sangue. A concentra\u00e7\u00e3o de SMP no LCR \u00e9 c\u00earca da quinta parte da encontrada no s\u00f4ro. Entre os pacientes com LCR alterado foi encontrado aumento da rela\u00e7\u00e3o em dois casos de polirradiculoneurite; em ambos havia concentra\u00e7\u00e3o elevada de SMP no LCR. Nos demais os val\u00f4res encontrados para a rela\u00e7\u00e3o n\u00e3o se afastavam daqueles verificados para pacientes com LCR normal.<\/jats:p>","DOI":"10.1590\/s0004-282x1963000300007","type":"journal-article","created":{"date-parts":[[2013,8,24]],"date-time":"2013-08-24T13:16:52Z","timestamp":1377350212000},"page":"197-202","source":"Crossref","is-referenced-by-count":0,"title":["Difus\u00e3o da sulfanilamido-metilpirimidina para o l\u00edquido cefalorraqueano"],"prefix":"10.1590","volume":"21","author":[{"given":"Tito","family":"Cavallo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ovidio D.","family":"Escalante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Spina-Fran\u00e7a","sequence":"additional","affiliation":[{"name":"Univ. de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","first-page":"524","article-title":"Ein Beitrag zu einem neuen Langzeitsulfonamid (Pallidin)","volume":"1","author":"BENZING H.","year":"1961","journal-title":"Medizinische Welt","ISSN":"http:\/\/id.crossref.org\/issn\/0025-8512","issn-type":"print"},{"key":"ref2","first-page":"32","article-title":"The diffusion of sulfonamides into the cerebrospinal fluid: a comparative study","volume":"6","author":"BOGER W. P.","year":"1959","journal-title":"Antibiot. Med. a. Clin. Therapy"},{"key":"ref3","first-page":"572","article-title":"Sulfamethoxazole: comparison with sulfizoxasole and sulfaethidole and cerebrospinal fluid diffusion","volume":"10","author":"BOGER W. P.","year":"1960","journal-title":"Antibiot. a. Chemoter."},{"key":"ref4","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0021-9258(18)73708-3","article-title":"A new coupling componente for sulfanilamide determination","volume":"128","author":"BRATTON A. C","year":"1939","journal-title":"J. Biol. Chem.","ISSN":"http:\/\/id.crossref.org\/issn\/0021-9258","issn-type":"print"},{"key":"ref5","first-page":"220","article-title":"Experimentelle Studien mit Sulfadimethoxin (Madribon) in der Paediatrie","volume":"90","author":"RENTSCH M.","year":"1960","journal-title":"Schweiz. Med. Wschr."},{"key":"ref6","first-page":"343","article-title":"Experimentelle und thera-peutische Resultate bei Klinischer Anwendung des 2-Sulfanilamido-5-methylpyrimidin (Pallidin)","volume":"1","author":"RUIZ-TORRES A.","year":"1961","journal-title":"Medizinische Welt","ISSN":"http:\/\/id.crossref.org\/issn\/0025-8512","issn-type":"print"},{"key":"ref7"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v21n3\/07.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T20:32:46Z","timestamp":1646425966000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X1963000300007&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1963,9]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1963,9]]}},"alternative-id":["S0004-282X1963000300007"],"URL":"https:\/\/doi.org\/10.1590\/s0004-282x1963000300007","relation":{},"ISSN":["0004-282X"],"issn-type":[{"value":"0004-282X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1963,9]]}}}