{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T23:29:14Z","timestamp":1697758154989},"reference-count":9,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[1981,9]]},"abstract":"<jats:p>Relato da avalia\u00e7\u00e3o do emprego do derivado pirazino-isoquinole\u00ednico Praziquantel em 20 pacientes com neurocisticercose observados entre julho-1979 e outubro-1980. \u00c9 considerado haver atua\u00e7\u00e3o do medicamento sobre os cisticercos que infestam o sistema nervoso em fun\u00e7\u00e3o de ocorrer exacerba\u00e7\u00e3o transit\u00f3ria da resposta inflamat\u00f3ria pr\u00f3pria \u00e0 s\u00edndrome do LCR na neurocisticercose, a qual \u00e9 coincidente ao uso da droga. H\u00e1 interfer\u00eancia de corticoster\u00f3ides nessa resposta, quando utilizados concomitantemente. Os resultados sugerem ser necess\u00e1rio utilizar maiores doses de Praziquantel e\/ou maior per\u00edodo de tratamento para obter atua\u00e7\u00e3o mais efetiva sobre os parasitas.<\/jats:p>","DOI":"10.1590\/s0004-282x1981000300002","type":"journal-article","created":{"date-parts":[[2012,8,25]],"date-time":"2012-08-25T04:37:35Z","timestamp":1345869455000},"page":"279-285","source":"Crossref","is-referenced-by-count":12,"title":["Neurocisticercose e Praziquantel: II. avalia\u00e7\u00e3o de resultados em 20 pacientes"],"prefix":"10.1590","volume":"39","author":[{"given":"A.","family":"Spina-Fran\u00e7a","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. P. S.","family":"N\u00f3brega","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"issue":"69","key":"ref1","article-title":"Clinical pharmacology in normal volunteers of praziquantel, a new drug against schistosomes and cestodes","volume":"14","author":"LEOPOLD G","year":"1978","journal-title":"Eur. J. clin. Pharmac"},{"issue":"65","key":"ref2","article-title":"Un caso de cisticercosis cerebral curado m\u00e9dimente","volume":"116","author":"ROBLES C","year":"1980","journal-title":"Gac. m\u00e9d. M\u00e9x","ISSN":"http:\/\/id.crossref.org\/issn\/0016-3813","issn-type":"print"},{"issue":"17","key":"ref3","article-title":"Aspectos biol\u00f3gicos da neurocisticercose: altera\u00e7\u00f5es do l\u00edquido cefalorraqueano","volume":"20","author":"SPINA-FRAN\u00c7A A","year":"1962","journal-title":"Arq. Neuro-Psiquiat. (S\u00e3o Paulo)"},{"issue":"125","key":"ref4","article-title":"Imunobiologia da cisticercose: avalia\u00e7\u00e3o dos conceitos atuais","volume":"27","author":"SPINA-FRAN\u00c7A A.","year":"1969","journal-title":"Arq. Neuro-Psiquiat. (S\u00e3o Paulo)"},{"issue":"180","key":"ref5","article-title":"Long term evolution of the pathology of cerebrospinal fluid globulins in cysticercosis of the central nervous system: a comparison with data in neurosyphilis and multiple sclerosis","volume":"427","author":"SPINA-FRAN\u00c7A A","year":"1977","journal-title":"Excerpta med. int. Congr. Ser."},{"issue":"34","key":"ref6","article-title":"Neurocisticercose e praziquantel: Nota pr\u00e9via","volume":"95","author":"SPINA-FRAN\u00c7A A.","year":"1980","journal-title":"Rev. paul. Med","ISSN":"http:\/\/id.crossref.org\/issn\/0035-0362","issn-type":"print"},{"issue":"2","key":"ref7","article-title":"- Resultados experimentales con praziquantel (Embay 8440) en cestodiasis y cisticercosis","volume":"32","author":"THOMAS H.","year":"1977","journal-title":"Bol. chileno Parasit."},{"issue":"556","key":"ref8","article-title":"Praziquantel: a new cestocide","volume":"8","author":"THOMAS H.","year":"1977","journal-title":"Pestic. Sci"},{"key":"ref9","series-title":"Tropical Neurology","first-page":"162","volume-title":"Histopathology of cerebral cysticercosis","author":"TRELLES J. O.","year":"1963"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v39n3\/02.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,27]],"date-time":"2017-05-27T04:47:26Z","timestamp":1495860446000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X1981000300002&lng=pt&tlng=pt"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,9]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,9]]}},"alternative-id":["S0004-282X1981000300002"],"URL":"https:\/\/doi.org\/10.1590\/s0004-282x1981000300002","relation":{},"ISSN":["0004-282X"],"issn-type":[{"value":"0004-282X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,9]]}}}