{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:40:54Z","timestamp":1789940454086,"version":"4.0.1"},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:p>We analysed sera and cerebrospinal fluid (CSF) of 20 cases of human T-cell lymphotropic virus type (HTLV-I) associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) from Brazil and Iran and as controls, 16 Brazilian HTLVI seronegative individuals afflicted with other neurological diseases. It was observed in the HAM\/TSP patients that: 1) all had an inflammatory reaction within the central nervous system (CNS); 2) 95% (19\/20) showed oligoclonal bands reflecting intrathecal IgG synthesis; 3) 85% (17\/20) presented a local synthesis of HTLVI antibodies; 4) 35% (7\/20) had a measurable immunoglobulin (Ig) synthesis within the CNS. The CSF parameters of the HAM\/TSP were compared with the clinical data (age at onset, duration of disease and disability level). Our data prove that CSF analysis is important for the diagnosis of HAM\/TSP. There is no association between the severity of the disease and CSF findings.<\/jats:p>","DOI":"10.1590\/s0004-282x1995000200005","type":"journal-article","created":{"date-parts":[[2011,4,9]],"date-time":"2011-04-09T17:03:33Z","timestamp":1302368613000},"page":"213-217","source":"Crossref","is-referenced-by-count":10,"title":["HTLV-I associated myelopathy in patients from Brazil and Iran: neurological manifestations and cerebrospinal fluid findings"],"prefix":"10.1590","volume":"53","author":[{"given":"Marzia","family":"Puccioni-Sohler","sequence":"first","affiliation":[{"name":"Georg-August-Universit\u00e1, Germany; Universidade Federal do Rio de Janeiro"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernid","family":"Kitze","sequence":"additional","affiliation":[{"name":"Georg-August-Universit\u00e1, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Felgenhauer","sequence":"additional","affiliation":[{"name":"Georg-August-Universit\u00e1, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","first-page":"213","article-title":"HTLV-I associated neurologic manifestations in four generations of a Brazilian family","volume":"6","author":"Cavalcanti M","year":"1993","journal-title":"J AIDS"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"S188","DOI":"10.1002\/ana.410230742","article-title":"Intrathecal synthesis of IgG antibodies to HTLV-I supports an etiological role for HTLV-I in tropical spastic paraparesis","volume":"23","author":"Ceroni M","year":"1988","journal-title":"Ann Neurol","ISSN":"https:\/\/id.crossref.org\/issn\/0364-5134","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(85)92734-5","article-title":"Antibodies 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entity","volume":"1","author":"Osame M","year":"1986","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/ana.410130302","article-title":"New diagnostic criteria for multiple sclerosis: guidelines for research protocols","volume":"13","author":"Poser CM","year":"1983","journal-title":"Ann Neurol","ISSN":"https:\/\/id.crossref.org\/issn\/0364-5134","issn-type":"print"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1093\/clinchem\/37.7.1153","article-title":"Quantification of virus specific antibodies in cerebrospinal fluid and serum: sensitive and specific detection of antibody synthesis in brain","volume":"37","author":"Reiber H","year":"1991","journal-title":"Clin Chem","ISSN":"https:\/\/id.crossref.org\/issn\/0009-9147","issn-type":"print"},{"key":"ref17","first-page":"190","article-title":"Human T lymphotropic virus type I 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