{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:30:10Z","timestamp":1791891010733,"version":"4.3.4"},"reference-count":10,"publisher":"FapUNIFESP (SciELO)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[1996,3]]},"abstract":"<jats:p>Paresthesiae-producing deep brain stimulation (stimulation of ventrocaudal nucleus - VC, medial lemniscus - ML or internal capsule - IC) is one of the few procedures to treat the steady element of neural injury pain (NIP) currently available. Reviewing the first 60 patients with NIP submitted to deep brain stimulation (DBS) from 1978 to 1991 at the Division of Neurosurgery, Toronto Hospital, University of Toronto, we observed that 6 patients complained of unpleasant paresthesiae with paresthesiae-producing DBS, preventing permanent electrode implantation in all of them. Such patients accounted for 15% of the failures (6 out of 40 failures) in our series. In an attempt to improve patient selection, we reviewed our patients considering a number of parameters in order to determine risk factors for unpleasant paresthesiae elicited by paresthesiae-producing DBS. The results showed that this response happenned only in patients with brain central pain complaining of evoked pain, secondary to a supratentorial lesion. Age, sex, duration of pain, quality of the steady pain, size of the causative lesion and site (VC,ML,IC) and type (micro or macroelectrode) of surgical exploration were not important factors. Unpleasant paresthesiae in response to dorsal column stimulation, restricted thalamic lesion on computed tomography and the occurrence of associated intermittent pain were considered major risk factors in this subset of patients and the presence of cold allodynia or hyperpathia in isolation and the absence of sensory loss were considered minor risk factors. It is our hope that the criteria here established will improve patient selection and so, the overall results of DBS.<\/jats:p>","DOI":"10.1590\/s0004-282x1996000100010","type":"journal-article","created":{"date-parts":[[2010,12,16]],"date-time":"2010-12-16T02:31:16Z","timestamp":1292466676000},"page":"57-63","source":"Crossref","is-referenced-by-count":6,"title":["Risk factors for unpleasant paresthesiae induced by paresthesiae - producing deep brain stimulation"],"prefix":"10.1590","volume":"54","author":[{"given":"Osvaldo","family":"Vilela Filho","sequence":"first","affiliation":[{"name":"Instituto Ortop\u00e9dico de Goi\u00e2nia; IOG; Universidade Federa\u00e7 de Goi\u00e1s; Universidade Federal de Goi\u00e1s; Toronto Hospital; University of Toronto"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1159\/000099504","article-title":"Thalamic stimulation and recording in patients with deafferentation and central pain","volume":"52","author":"Gorecki J","year":"1989","journal-title":"Stereotact Funct Neurosurg","ISSN":"https:\/\/id.crossref.org\/issn\/1011-6125","issn-type":"print"},{"key":"ref2","first-page":"261","article-title":"Identification of pain processing systems by electrical stimulation of the brain","volume":"1","author":"Tasker RR","year":"1982","journal-title":"Human Neurobiol"},{"key":"ref3","series-title":"Textbook of pain","first-page":"154","volume-title":"Deafferentation and central pain","author":"Tasker RR","year":"1989","edition":"2"},{"key":"ref4","first-page":"414","article-title":"Thalamic microelectrode recording and microstimulation in central and deafferentation pain","volume":"50","author":"Tasker RR","year":"1987","journal-title":"Appl Neurophysiol","ISSN":"https:\/\/id.crossref.org\/issn\/0302-2773","issn-type":"print"},{"key":"ref5","series-title":"The thalamus and midbrain of man: a physiological atlas using electrical stimulation","first-page":"154","volume-title":"The spinothalamic pathway","author":"Tasker RR","year":"1982"},{"key":"ref6","series-title":"Advances in pain research and therapy","first-page":"713","volume-title":"Clinical neurophysiological investigation of deafferentation pain","author":"Tasker RR","year":"1983"},{"key":"ref7","series-title":"Neurological surgery","first-page":"3512","volume-title":"Deep brain stimulation for the control of untreatable pain","author":"Tasker RR","year":"1996","edition":"4"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1540-8159.1991.tb04058.x","article-title":"Treatment of thalamic pain by chronic motor cortex stimulation","volume":"14","author":"Tsubokawa T","year":"1991","journal-title":"Pace","ISSN":"https:\/\/id.crossref.org\/issn\/0147-8389","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1590\/S0004-282X1994000400022","article-title":"Thalamic ventrobasal stimulation for pain relief: probable mechanisms, pathways and neurotransmitters","volume":"52","author":"Vilela O Filho","year":"1994","journal-title":"Arq Neuropsiquiatr","ISSN":"https:\/\/id.crossref.org\/issn\/0004-282X","issn-type":"print"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1590\/S0004-282X1994000300016","article-title":"Pathways involved in thalamic ventrobasal stimulation for pain relief: evidence against the hypothesis VB stimulation -> rostroventral medulla excitation -> dorsal horn inhibition","volume":"52","author":"Vilela O Filho","year":"1994","journal-title":"Arq Neuropsiquiatr","ISSN":"https:\/\/id.crossref.org\/issn\/0004-282X","issn-type":"print"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v54n1\/10.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T18:02:14Z","timestamp":1495821734000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X1996000100010&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["S0004-282X1996000100010"],"URL":"https:\/\/doi.org\/10.1590\/s0004-282x1996000100010","relation":{},"ISSN":["0004-282X"],"issn-type":[{"value":"0004-282X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,3]]}}}