{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,6,4]],"date-time":"2023-06-04T02:10:55Z","timestamp":1685844655530},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[1997,6]]},"abstract":"<jats:p>A hip\u00f3tese de que a apn\u00e9ia pudesse ser o evento final da s\u00edndrome da morte s\u00fabita da inf\u00e2ncia (SMSI) deu origem a v\u00e1rios estudos avaliando as caracter\u00edsticas deste evento do ponto de vista polissonogr\u00e1fico. Foi sugerido que a atividade f\u00e1sica do sono REM estaria associada a ativa\u00e7\u00e3o dos neur\u00f4nios respirat\u00f3rios prevenindo a ocorr\u00eancia de apn\u00e9ias prolongadas e protegendo os lactentes de evolu\u00edrem para SMSI. Em estudo pr\u00e9vio retrospectivo com rec\u00e9m-nascidos n\u00e3o confirmamos estes achados mas muitos destes beb\u00eas apresentavam comprometimento neurol\u00f3gico severo. O objetivo do presente estudo \u00e9 verificar a rela\u00e7\u00e3o existente entre per\u00edodos de atividade f\u00e1sica do sono REM (movimentos oculares r\u00e1pidos e movimentos de suc\u00e7\u00e3o) e apn\u00e9ia. Estudamos do ponto de vista cl\u00ednico c polissonogr\u00e1fico 86 rec\u00e9m-nascidos c lactentes encaminhados para avalia\u00e7\u00e3o por terem apresentado apn\u00e9ia ou epis\u00f3dios com aparente risco de vida durante o sono. Dividimos os pacientes em 3 grupos: rec\u00e9m-nascidos (idade concepcional inferior a 44 semanas, n=31), lactentes com 1 -6 meses (n=48) e lactentes com &gt;6m&lt;12 meses (n=7). Todos foram submetidos a avalia\u00e7\u00e3o cl\u00ednica e neurol\u00f3gica para detectar poss\u00edveis fatores etiol\u00f3gicos das apn\u00e9ias. As polissonografias constavam de EEG, eletromiograma submentoniano, eletro-oculograma e monitoriza\u00e7\u00e3o cardiorrespirat\u00f3ria, todas com dura\u00e7\u00e3o de 2 a 3 horas. Durante 5 minutos cont\u00ednuos de sono REM verificamos a incid\u00eancia de atividade f\u00e1sica relacionada a per\u00edodos em apn\u00e9ia e comparamos sua incid\u00eancia em per\u00edodos semelhantes sem apn\u00e9ia. Nossos resultados mostraram que a atividade f\u00e1sica do sono REM ocorre com maior freq\u00fc\u00eancia em per\u00edodos sem apn\u00e9ia. No per\u00edodo neonatal os movimentos de suc\u00e7\u00e3o (p &lt; 0.05) e nos lactentes com 1-6 meses os movimentos oculares r\u00e1pidos (p=0,001). N\u00e3o houve diferen\u00e7a estatisticamente significativa nos lactentes &gt;6&lt;12 meses. Nossos resultados mostram que a atividade f\u00e1sica do sono REM \u00e9 mais frequente cm per\u00edodos sem apn\u00e9ia durante os 6 primeiros meses de vida, per\u00edodo que coincide com o maior risco de SMSI. Sugerimos que o \"driving\" excitat\u00f3rio que determina o aparecimento da atividade f\u00e1sica possa ter efeito protetor contra apn\u00e9ias atrav\u00e9s do bloqueio ou atenua\u00e7\u00e3o da inibi\u00e7\u00e3o t\u00f4nica do centro respirat\u00f3rio que determinaria a apn\u00e9ia. Estudos futuros s\u00e3o necess\u00e1rios para avaliar a rela\u00e7\u00e3o entre perda desse \"mecanismo de prote\u00e7\u00e3o\"e SMSI.<\/jats:p>","DOI":"10.1590\/s0004-282x1997000200008","type":"journal-article","created":{"date-parts":[[2010,10,28]],"date-time":"2010-10-28T02:08:36Z","timestamp":1288231716000},"page":"213-219","source":"Crossref","is-referenced-by-count":0,"title":["Atividade f\u00e1sica do sono rem em rec\u00e9m-nascidos e lactentes e sua rela\u00e7\u00e3o com epis\u00f3dios de apn\u00e9ia"],"prefix":"10.1590","volume":"55","author":[{"given":"Magda Lahorgue","family":"Nunes","sequence":"first","affiliation":[{"name":"PUC-RS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaderson Costa da","family":"Costa","sequence":"additional","affiliation":[{"name":"PUC-RS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Let\u00edcia","family":"Taufer","sequence":"additional","affiliation":[{"name":"PUC-RS"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","series-title":"A manual of standardized terminology, techniques and criteria for scoring states of sleep and wakefulness in newborn infants","author":"Anders T","year":"1971"},{"key":"ref2","series-title":"Apnea and SIDS","first-page":"809","volume-title":"Apparent life-threatening events and apnea of infancy","author":"Brooks JG","year":"1992"},{"key":"ref3","series-title":"Sono aspectos atuais","first-page":"133","volume-title":"O sono em rec\u00e9m-nascidos: aspectos polissonogr\u00e1ficos","author":"Da Costa JC","year":"1990"},{"key":"ref4","first-page":"531","article-title":"A prospective study of the apneas and its relationship with the phasic activity of REM 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