{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:51:03Z","timestamp":1761058263295},"reference-count":33,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[1998,12]]},"abstract":"<jats:p>A s\u00edndrome neurol\u00e9ptica maligna (SNM) consiste em rea\u00e7\u00e3o idiossincr\u00e1tica a neurol\u00e9pticos, provavelmente relacionada a bloqueio dos receptores dopamin\u00e9rgicos nos g\u00e2nglios da base, sendo por isso tamb\u00e9m conhecida como s\u00edndrome da defici\u00eancia aguda de dopamina.A SNM \u00e9 caracterizada por hiperpirexia, altera\u00e7\u00e3o do n\u00edvel de consci\u00eancia, hipertonia, disfun\u00e7\u00e3o auton\u00f4mica e insufici\u00eancia respirat\u00f3ria, podendo ainda ser encontrados rabdomi\u00f3lise e leucocitose. O haloperidol \u00e9 a droga mais frequentemente associada \u00e0 s\u00edndrome. Relatamos o caso de um paciente de 30 anos que apresentou SNM em duas ocasi\u00f5es diferentes, a primeira delas relacionada ao uso de haloperidol e clorpromazina e a segunda relacionada ao uso de olanzapina, fato este sem men\u00e7\u00e3o anterior na literatura indexada.<\/jats:p>","DOI":"10.1590\/s0004-282x1998000500022","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T10:23:01Z","timestamp":1113560581000},"page":"833-837","source":"Crossref","is-referenced-by-count":14,"title":["S\u00edndrome neurol\u00e9ptica maligna: relato de caso com recorr\u00eancia associada ao uso de olanzapina"],"prefix":"10.1590","volume":"56","author":[{"given":"RICARDO A.","family":"HANEL","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARCOS C.","family":"SANDMANN","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTINA","family":"KRANICH","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PAULO R. 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