{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:38:05Z","timestamp":1767339485480},"reference-count":60,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[1998,12]]},"abstract":"<jats:p>A fisiopatologia da enxaqueca ainda n\u00e3o foi completamente elucidada. As principais estruturas envolvidas parecem ser o sistema nervoso central (c\u00f3rtex e tronco cerebral), o sistema trigeminovascular e os vasos correspondentes, outras fibras auton\u00f4micas que inervam estes vasos, e os v\u00e1rios agentes vasoativos locais, como a SP, CGRP, NO, VIP, NPY, ACh, NA, NKA, entre outros. A depress\u00e3o alastrante \u00e9 o fen\u00f4meno neurol\u00f3gico que provavelmente justifica achados experimenais e cl\u00ednicos na enxaqueca. Ela tem velocidade de propaga\u00e7\u00e3o semelhante \u00e0 aura, ativa o n\u00facleo espinhal do trig\u00eameo e est\u00e1 relacionada \u00e0 libera\u00e7\u00e3o de CGRP e NO. Altera\u00e7\u00f5es circulat\u00f3rias detectadas por m\u00e9todos complementares refor\u00e7am o papel da depress\u00e3o alastrante. A identifica\u00e7\u00e3o de anormalidades em pelo menos tr\u00eas loci (cromossomas 19 e 1) na enxaqueca hemipl\u00e9gica familiar ocorreu recentemente. Elas est\u00e3o relacionadas a anormalidades nos canais de c\u00e1lcio voltagem dependentes tipo P\/Q, espec\u00edficos do sistema nervoso central, que regulam a libera\u00e7\u00e3o de v\u00e1rios neurotransmissores, incluindo possivelmente a serotonina. A exemplo de outras anormalidades neurol\u00f3gicas parox\u00edsticas que resultam da hiperexcitabilidade da membrana plasm\u00e1tica, \u00e9 poss\u00edvel que a enxaqueca ocorra devido a uma desordem de canais i\u00f4nicos.<\/jats:p>","DOI":"10.1590\/s0004-282x1998000500024","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:23:01Z","timestamp":1113574981000},"page":"841-851","source":"Crossref","is-referenced-by-count":6,"title":["Fisiopatologia da enxaqueca"],"prefix":"10.1590","volume":"56","author":[{"given":"MAURICE B.","family":"VINCENT","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1001\/archneurpsyc.1938.02270040093005","article-title":"Mechanism of migraine headache and action of ergotamine tartrate","volume":"39","author":"Graham 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