{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T19:10:15Z","timestamp":1735672215877,"version":"3.32.0"},"reference-count":18,"publisher":"FapUNIFESP (SciELO)","issue":"2A","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:p>Estudos recentes sugerem uma associa\u00e7\u00e3o entre febre reum\u00e1tica (FR) e transtornos do espectro obsessivo-compulsivo, o que levou \u00e0 hip\u00f3tese de que altera\u00e7\u00f5es na resposta imune pudessem ter um papel na etiologia destes \u00faltimos. Um marcador biol\u00f3gico que talvez identifique maior susceptibilidade para o desenvolvimento de FR e desses transtornos neuropsiqui\u00e1tricos tem causado grande interesse na literatura. Trata-se do D8\/17, um anticorpo monoclonal contra um ant\u00edgeno de membrana de linf\u00f3citos B. Neste artigo introduzimos conhecimentos sobre o D8\/17 e discutimos suas implica\u00e7\u00f5es como um poss\u00edvel marcador biol\u00f3gico de transtornos neuropsiqui\u00e1tricos associados ou n\u00e3o \u00e0 FR.<\/jats:p>","DOI":"10.1590\/s0004-282x2000000200028","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:25:47Z","timestamp":1113575147000},"page":"366-370","source":"Crossref","is-referenced-by-count":0,"title":["Marcador D8-17: implica\u00e7\u00f5es para a neuropsiquiatria"],"prefix":"10.1590","volume":"58","author":[{"given":"JULIANA","family":"DINIZ","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"PEDRO GOMES DE","family":"ALVARENGA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ANA","family":"HOUNIE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EURIPEDES 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