{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T05:39:44Z","timestamp":1785476384391,"version":"3.56.0"},"reference-count":16,"publisher":"FapUNIFESP (SciELO)","issue":"2B","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:p>PURPOSE: To report the clinical features and outcome of a series of children with optic neuritis. METHODS: We reviewed the medical records of patients up to 16 years old with optic neuritis. Group 1 comprised children seen up to two weeks after the onset of visual loss; Group 2 comprised patients already harboring optic atrophy. RESULTS: There were 15 boys and 12 girls. The mean age was 10.9 years. Bilateral optic neuritis occurred in 10. Optic disc pallor was found in 35%, edema in 46%, and 19% had normal fundus. During follow-up visual acuity improved in all but one eye in Group 1, and in six of seven eyes in children in Group 2. Just one child converted to multiple sclerosis. CONCLUSIONS: This study shows that the clinical features of childhood optic neuritis differ from those observed in adults. In children it has a better visual outcome and a lower conversion rate to multiple sclerosis than in adults.<\/jats:p>","DOI":"10.1590\/s0004-282x2001000300001","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:29:16Z","timestamp":1113575356000},"page":"311-317","source":"Crossref","is-referenced-by-count":44,"title":["The clinical profile of childhood optic neuritis"],"prefix":"10.1590","volume":"59","author":[{"given":"Marco Aur\u00e9lio","family":"Lana-Peixoto","sequence":"first","affiliation":[{"name":"Federal University of Minas Gerais Medical School, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Cardoso de","family":"Andrade","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais Medical School, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1542\/peds.28.3.377","article-title":"Relation of optic neuritis to multiple sclerosis in children","volume":"28","author":"Kennedy C","year":"1961","journal-title":"Pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0031-4005","issn-type":"print"},{"key":"ref2","series-title":"Optic Neuritis","first-page":"73","volume-title":"Optic neuritis in childhood","author":"Taylor D","year":"1986"},{"key":"ref3","first-page":"603","article-title":"The Downe Memorial Lecture: Retrobulbar and optic neuritis in childhood and adolescence","volume":"89","author":"Meadows SP","year":"1969","journal-title":"Trans Ophthalmol Soc UK"},{"key":"ref4","first-page":"563","article-title":"N\u00e9vrites optiques de l'\u00e9nfant: Aspects cliniques et \u00e9volutifs. 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