{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:30:24Z","timestamp":1760016624976},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"2B","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2002,6]]},"abstract":"<jats:p>We report the case of a 41-year-old man with iatrogenic Creutzfeldt-Jakob disease (CJD) acquired after the use of growth hormone (GH) obtained from a number of pituitary glands sourced from autopsy material. The incubation period of the disease (from the midpoint of treatment to the onset of clinical symptoms) was rather long (28 years). Besides the remarkable cerebellar and mental signs, the patient exhibited sleep disturbance (excessive somnolence) from the onset of the symptoms, with striking alteration of the sleep architecture documented by polysomnography. 14-3-3 protein was detected in the CSF, and MRI revealed increased signal intensity bilaterally in the striatum, being most evident in diffusion-weighted (DW-MRI) sequences. This is the second case of iatrogenic CJD associated with the use of GH reported in Brazil.<\/jats:p>","DOI":"10.1590\/s0004-282x2002000300022","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:31:45Z","timestamp":1113575505000},"page":"458-461","source":"Crossref","is-referenced-by-count":13,"title":["Iatrogenic Creutzfeldt-Jakob disease following human growth hormone therapy: case report"],"prefix":"10.1590","volume":"60","author":[{"given":"Lu\u00eds Ot\u00e1vio Sales Ferreira","family":"Caboclo","sequence":"first","affiliation":[{"name":"University of S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Huang","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme Alves","family":"Lepski","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Ant\u00f4nio","family":"Livramento","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Alberto","family":"Buchpiguel","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia Sellitto","family":"Porto","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Nitrini","sequence":"additional","affiliation":[{"name":"University of S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","series-title":") Prion diseases","first-page":"18","volume-title":"Human prion diseases","author":"Collinge 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