{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T07:14:26Z","timestamp":1793949266714,"version":"4.8.0"},"reference-count":33,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p>A mielin\u00f3lise pontina central (MPC) e extra-pontina (MEP) \u00e9 enfermidade desmielinizante do enc\u00e9falo associada principalmente com a corre\u00e7\u00e3o r\u00e1pida da hiponatremia, que se manifesta principalmente por tetraparesia esp\u00e1stica e paralisia pseudo-bulbar. Existem na literatura poucos relatos de MPC\/MEP em pacientes sem evid\u00eancias de dist\u00farbios hidro-eletrol\u00edticos. Relatamos o caso de um paciente de 39 anos de idade, com hist\u00f3ria de alcoolismo intenso, com quadro de r\u00e1pida evolu\u00e7\u00e3o com tetraparesia esp\u00e1stica associada a paresia de diversos nervos cranianos, com exame de resson\u00e2ncia magn\u00e9tica demonstrando les\u00f5es compat\u00edveis com MPC\/MEP. Houve boa evolu\u00e7\u00e3o cl\u00ednica ap\u00f3s tratamento com costicoster\u00f3ide.<\/jats:p>","DOI":"10.1590\/s0004-282x2002000600028","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:33:23Z","timestamp":1113575603000},"page":"1030-1033","source":"Crossref","is-referenced-by-count":10,"title":["Mielin\u00f3lise pontina central e extra-pontina em paciente alcoolista sem dist\u00farbios hidro-eletrol\u00edticos: relato de caso"],"prefix":"10.1590","volume":"60","author":[{"given":"Francisco Manoel B.","family":"Germiniani","sequence":"first","affiliation":[{"name":"Universidade Federal do Parana, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio","family":"Roriz","sequence":"additional","affiliation":[{"name":"Universidade Federal do Parana, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir K.","family":"Nabhan","sequence":"additional","affiliation":[{"name":"Universidade Federal do Parana, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helio A.G.","family":"Teive","sequence":"additional","affiliation":[{"name":"Universidade Federal do Parana, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lineu C.","family":"Werneck","sequence":"additional","affiliation":[{"name":"Universidade Federal do Parana, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.7326\/0003-4819-126-1-199701010-00008","article-title":"Myelinolysis after correction of hyponatremia","volume":"126","author":"Laureno R","year":"1997","journal-title":"Ann Intern Med","ISSN":"https:\/\/id.crossref.org\/issn\/0003-4819","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1001\/archneurpsyc.1959.02340140020004","article-title":"Central pontine myelinolysis: a hitherto undescribed disease ocurring in alcoholics and malnourished patients","volume":"8","author":"Adams RA","year":"1959","journal-title":"Arch Neurol Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0096-6754","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/brain\/102.2.361","article-title":"Pontine and extrapontine myelinolisis","volume":"102","author":"Wright DG","year":"1979","journal-title":"Brain","ISSN":"https:\/\/id.crossref.org\/issn\/0006-8950","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1212\/WNL.27.3.223","article-title":"Hyponatremia and central pontine myelinolysis","volume":"27","author":"Burcar PJ","year":"1977","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"key":"ref5","first-page":"373","article-title":"Central pontine myelinolisis: two cases with associated electrolyte disturbance","volume":"45","author":"Tomlinson BE","year":"1976","journal-title":"QJMed"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1681\/ASN.V481522","article-title":"Neurologic sequelae after treatment of severe hyponatremia: a multicenter perspective","volume":"4","author":"Sterns RH","year":"1994","journal-title":"J Am Soc Nephrol","ISSN":"https:\/\/id.crossref.org\/issn\/1046-6673","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0140-6736(87)90294-7","article-title":"Neurological complications following liver transplantation","volume":"1","author":"Adams DH","year":"1987","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1212\/WNL.39.4.493","article-title":"Central pontine myelinolysis after liver transplantation","volume":"39","author":"Estol CJ","year":"1989","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00427209","article-title":"Neuropathologic findings after liver transplantation","volume":"84","author":"Ferreiro JA","year":"1992","journal-title":"Acta Neuropathol (Berl)","ISSN":"https:\/\/id.crossref.org\/issn\/0001-6322","issn-type":"print"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/00005792-199403000-00004","article-title":"Central nervous system lesions in adult liver transplant recipients: clinical review with implications for management","volume":"73","author":"Singh N","year":"1994","journal-title":"Medicine (Baltimore)","ISSN":"https:\/\/id.crossref.org\/issn\/0025-7974","issn-type":"print"},{"key":"ref11","first-page":"1006","article-title":"Pontine and extrapontine myelinolysis following liver transplantation","volume":"48","author":"Wszolek ZK","year":"1989","journal-title":"Relationship to serum sodium. 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