{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T23:15:50Z","timestamp":1768086950804,"version":"3.49.0"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"2A","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:p>With the aim of analyzing which complementary tests are relevant in the diagnostic evaluation of individuals with pervasive developmental disorders, a protocol of clinical and laboratory evaluation was applied in 103 outpatients. The protocol included chromosomal analysis, screening for inborn errors of metabolism, cytogenetic and molecular study of the FRAXA, FRAXE, and FRAXF mutations, EEG, SPECT, and magnetic resonance imaging study. Eighty-four subjects concluded the complementary tests and were classified either as having autism, atypical autism or Asperger syndrome according to the DSM-IV criteria. Sixteen individuals, all bellonging to the two autistic groups, presented genetic or enviromental factors that may have lead to the behavioral disorders, showing the importance of diagnostic evaluation in this group of conditions. Neuroimaging and EEG findings were non-specific and occurred in similar proportion among the groups, being considered of relative low significance in the diagnostic evaluation of individuals with pervasive developmental disorders.<\/jats:p>","DOI":"10.1590\/s0004-282x2003000200003","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:34:57Z","timestamp":1113575697000},"page":"176-180","source":"Crossref","is-referenced-by-count":18,"title":["Genetic and neurological evaluation in a sample of individuals with pervasive developmental disorders"],"prefix":"10.1590","volume":"61","author":[{"given":"Carlos Eduardo","family":"Steiner","sequence":"first","affiliation":[{"name":"Universidade Estadual de Campinas, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilisa Mantovani","family":"Guerreiro","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Brasil; Universidade Estadual de Campinas, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonia Paula","family":"Marques-de-Faria","sequence":"additional","affiliation":[{"name":"Universidade Estadual de Campinas, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","series-title":"American Psychiatric Press, Diagnostic and statistical manual of mental disorders","year":"1994","edition":"4"},{"issue":"Suppl","key":"ref2","first-page":"751","article-title":"Autistic children: diagnosis and clinical features","volume":"87","author":"Rapin I","year":"1991","journal-title":"Pediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0031-4005","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/070674379504000603","article-title":"Current research findings on childhood autism","volume":"40","author":"Sigman M","year":"1995","journal-title":"Can J Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0706-7437","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1469-7610.1988.tb00714.x","article-title":"The neurobiology of infantile autism","volume":"29","author":"Gillberg C","year":"1988","journal-title":"J Child Psychol Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9630","issn-type":"print"},{"key":"ref5","first-page":"1561","article-title":"Autism and associated medical disorders in a French epidemiological survey","volume":"36","author":"Fommbonne E","year":"1997","journal-title":"J Am Acad Child Adolesc Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0890-8567","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0387-7604(98)00031-X","article-title":"Childhood autism: the need for physical investigations","volume":"20","author":"Skjedal OH","year":"1998","journal-title":"Brain Dev","ISSN":"https:\/\/id.crossref.org\/issn\/0387-7604","issn-type":"print"},{"key":"ref7","series-title":"Aspectos gen\u00e9ticos e neurol\u00f3gicos do autismo; proposta de abordagem interdisciplinar na avalia\u00e7\u00e3o diagn\u00f3stica do autismo e dist\u00farbios correlatos. 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