{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T07:33:02Z","timestamp":1793172782888,"version":"4.5.0"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"2A","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:p>The psychiatric examination was performed with diagnostic instruments for autism (DSM-IV and Childhood Autism Rating Scale-CARS) in 23 children with M\u00f6bius sequence. From the 23 patients studied with M\u00f6bius sequence, five (26.1%) met the diagnostic criteria for infantile autism according DSM-IV and two (8.6%), under two years old, showed autistic-like behavior. The scores for six children were compatible to severe autism symptoms according CARS and one child met the criteria for moderate autism symptoms. Among five children with autism, three (60%) had positive history of misoprostol exposure during the first trimester of pregnancy and from two cases autistic-like, one (50%) had positive history of misoprostol exposure during pregnancy.According to our data, this is the first report of M\u00f6bius sequence with autism and positive history of misoprostol use during pregnancy.<\/jats:p>","DOI":"10.1590\/s0004-282x2003000200004","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T10:34:57Z","timestamp":1113561297000},"page":"181-185","source":"Crossref","is-referenced-by-count":83,"title":["Autism and M\u00f6bius sequence: an exploratory study of children in northeastern Brazil"],"prefix":"10.1590","volume":"61","author":[{"given":"Jos\u00e9 Marcelino","family":"Bandim","sequence":"first","affiliation":[{"name":"Universidade Federal de Pernambuco; Instituto Materno Infantil de Pernambuco,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana O.","family":"Ventura","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Altino Ventura; Hospital de Olhos de Pernambuco,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn T.","family":"Miller","sequence":"additional","affiliation":[{"name":"Universidade de Illinois,  EUA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henderson C.","family":"Almeida","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Elizabeth Santos","family":"Costa","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o de Assist\u00eancia \u00e0 Crian\u00e7a Deficiente,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1017\/S0954579499002217","article-title":"Neurodevelopmental process psychological functioning in autism","volume":"11","author":"Gillberg C","year":"1999","journal-title":"Dev Psychopathol","ISSN":"https:\/\/id.crossref.org\/issn\/0954-5794","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"32S","DOI":"10.1016\/S0890-8567(99)80003-3","article-title":"Practice parameters for the assessment and treatment of children, adolescents, and adults with autism and other pervasive developmental disorders","volume":"38","year":"1999","journal-title":"J Am Acad Child Adolesc Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0890-8567","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1176\/ajp.151.9.1361","article-title":"Field trial for autistic disorder in DSM-IV","volume":"151","author":"Volkmar FR","year":"1994","journal-title":"Am J Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0002-953X","issn-type":"print"},{"key":"ref4","series-title":"The autism spectrum","author":"Wing L","year":"1996"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S1071-9091(97)80024-1","article-title":"Language disorders in children with autism","volume":"4","author":"Rapin I","year":"1997","journal-title":"Sem Pediatr Neurol"},{"key":"ref6","first-page":"369","article-title":"The puzzle of autism: an ophthalmologic contribution","volume":"XCVI","author":"Miller M","year":"1998","journal-title":"Trans Am Ophthalmol Soc","ISSN":"https:\/\/id.crossref.org\/issn\/0065-9533","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1469-8749.1996.tb15081.x","article-title":"Autism and medical disorders: a review of the literature","volume":"38","author":"Gillberg C","year":"1996","journal-title":"Dev Med Child Neurol","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1622","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1469-7610.1994.tb01164.x","article-title":"Autism and known medical conditions: myth and substance","volume":"35","author":"Rutter M","year":"1994","journal-title":"J Child Psychol Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9630","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1091-8531(99)70003-0","article-title":"The M\u00f6bius sequence: a relook","volume":"3","author":"Miller M","year":"1999","journal-title":"J AAPOS"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1017\/S0012162201000627","article-title":"Autism spectrum disorders in M\u00f6bius sequence: a comprehensive study of 25 cases","volume":"43","author":"Johansson M","year":"2001","journal-title":"Dev Med Child Neurol","ISSN":"https:\/\/id.crossref.org\/issn\/0012-1622","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF01538999","article-title":"The early development of autistic children","volume":"7","author":"Ornitz EM","year":"1977","journal-title":"J Autism Dev Disord","ISSN":"https:\/\/id.crossref.org\/issn\/0162-3257","issn-type":"print"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1651-2227.1989.tb11076.x","article-title":"Autistic behavior in Moebius syndrome","volume":"79","author":"Gillberg C","year":"1989","journal-title":"Acta Paediatr","ISSN":"https:\/\/id.crossref.org\/issn\/0001-656X","issn-type":"print"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1365-2788.1992.tb00508.x","article-title":"Subgroups in autism: are there behavioral phenotypes typical of underlying medical conditions?","volume":"36","author":"Gillberg, C","year":"1992","journal-title":"J Intellect Disabil Res","ISSN":"https:\/\/id.crossref.org\/issn\/0964-2633","issn-type":"print"},{"key":"ref14","first-page":"315","article-title":"Is misoprostol teratogenic? Misoprostol use during early pregnancy and its association with M\u00f6bius syndrome","volume":"45","author":"Pottie K","year":"1999","journal-title":"Can Fam Physician","ISSN":"https:\/\/id.crossref.org\/issn\/0008-350X","issn-type":"print"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0010-7824(94)90084-1","article-title":"Misoprostol: The experience of women in Fortaleza, Brasil","volume":"49","author":"Coelho HL","year":"1994","journal-title":"Contraception","ISSN":"https:\/\/id.crossref.org\/issn\/0010-7824","issn-type":"print"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/0140-6736(91)92102-8","article-title":"Uterine contractility and induction of abortion in early pregnancy by misoprostol and mifepristone","volume":"338","author":"Norman JE","year":"1991","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1016\/S0140-6736(97)12363-7","article-title":"Congenital abnormalities in Brazilian children associated with misoprostol misuse in first trimester of pregnancy","volume":"351","author":"Gonzalez CH","year":"1998","journal-title":"Lancet","ISSN":"https:\/\/id.crossref.org\/issn\/0099-5355","issn-type":"print"},{"key":"ref18","first-page":"173","article-title":"S\u00edndrome de M\u00f6bius relacionada \u00e0 amea\u00e7a de abortamento","volume":"59","author":"Boudoux DD","year":"2000","journal-title":"Rev Bras Oftalmol","ISSN":"https:\/\/id.crossref.org\/issn\/0034-7280","issn-type":"print"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00019605-199901000-00010","article-title":"Terminal transverse limb defects with tethering and omphacele in a 17 week fetus following first trimester misoprostol exposure","volume":"8","author":"Genest DR","year":"1999","journal-title":"Clin Dysmorphol","ISSN":"https:\/\/id.crossref.org\/issn\/0962-8827","issn-type":"print"},{"key":"ref20","series-title":"Diagnostic and statistical manual of mental disorders","year":"1994","edition":"4"},{"key":"ref21","series-title":"Diagnosis and assessment in autism","author":"Schopler E","year":"1988"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1017\/S0033291799008508","article-title":"The epidemiology of autism: a review","volume":"29","author":"Fombonne E","year":"1999","journal-title":"Psychol Med","ISSN":"https:\/\/id.crossref.org\/issn\/0033-2917","issn-type":"print"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1002\/ajmg.1320230405","article-title":"Subclavian artery supply disruption sequence: hypothesis of a vascular etiology for Poland, Kippel-Feil, and M\u00f6bius anomalies","volume":"23","author":"Bavinck JNB","year":"1986","journal-title":"Am J Med Genet."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/tera.1420350212","article-title":"Uterine trauma and limb defects","volume":"35","author":"Webster WS","year":"1987","journal-title":"Teratology","ISSN":"https:\/\/id.crossref.org\/issn\/0040-3709","issn-type":"print"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/088307389701200315","article-title":"Uterine contraction in the development of M\u00f6bius syndrome","volume":"12","author":"Graf WD","year":"1997","journal-title":"J Child Neurol","ISSN":"https:\/\/id.crossref.org\/issn\/0883-0738","issn-type":"print"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1590\/S0004-282X2001000500031","article-title":"S\u00edndrome de Moebius: relato de caso","volume":"59","author":"Fontenelle L","year":"2001","journal-title":"Arq Neuropsiquiatr","ISSN":"https:\/\/id.crossref.org\/issn\/0004-282X","issn-type":"print"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/(SICI)1096-9861(19960624)370:2<247::AID-CNE8>3.0.CO;2-2","article-title":"Embriology origin for autism: developmental anomalies of cranial nerve motor nuclei","volume":"370","author":"Rodier PM","year":"1996","journal-title":"J Comp Neurol","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9967","issn-type":"print"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0892-0362(97)00020-2","article-title":"Is there a zone of vascular vulnerability in the fetal, brain stem?","volume":"19","author":"Leong S","year":"1997","journal-title":"Neurotoxicol Teratol","ISSN":"https:\/\/id.crossref.org\/issn\/0892-0362","issn-type":"print"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1177\/070674379904400806","article-title":"Imaging of autism: lessons from the past to guide studies in the future","volume":"44","author":"Goldberg J","year":"1999","journal-title":"Can J Psychiatry","ISSN":"https:\/\/id.crossref.org\/issn\/0706-7437","issn-type":"print"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v61n2a\/15679.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T19:02:11Z","timestamp":1495652531000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X2003000200004&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6]]},"references-count":29,"journal-issue":{"issue":"2A","published-print":{"date-parts":[[2003,6]]}},"alternative-id":["S0004-282X2003000200004"],"URL":"https:\/\/doi.org\/10.1590\/s0004-282x2003000200004","relation":{},"ISSN":["0004-282X"],"issn-type":[{"value":"0004-282X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6]]}}}