{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:40:38Z","timestamp":1777894838323,"version":"3.51.4"},"reference-count":18,"publisher":"FapUNIFESP (SciELO)","issue":"2B","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2003,6]]},"abstract":"<jats:p>A paraganglioma is a rare tumor, composed of chromaffin cells, groups of cells associated to the autonomous system. When the tumor occurs in the adrenal gland, it is called pheochromocitoma. The malignant paraganglioma is a very rare presentation; it is diagnosed by local recurrence after total resection of the primary mass, or findings of distant metastases. We present a case report of a 29-year-old woman with cervico-brachial pain. In 1995 she underwent a carotid body tumor resection. Magnetic resonance imaging (MRI), plain X-rays and computerized tomography scan revealed multiple lesions in C5, T5 and T12. She underwent a surgical procedure to correct the cervical lesion. The histological and immunohistochemical assays revealed a malignant paraganglioma. She received adjuvant radiotherapy, showing clinical improvement after treatment, presenting no symptoms after one year. The therapeutic approach is based on the total resection of the tumor. The treatment of distant metastases can be made with adjuvant measures such as conventional radiotherapy, I\u00b9\u00b3\u00b9-MIBG, or chemotherapy, especially in malignant pheochromocitomas.<\/jats:p>","DOI":"10.1590\/s0004-282x2003000300026","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:35:25Z","timestamp":1113575725000},"page":"463-467","source":"Crossref","is-referenced-by-count":27,"title":["Malignant paraganglioma with vertebral metastasis: case report"],"prefix":"10.1590","volume":"61","author":[{"given":"Bruno","family":"L\u00e1zaro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f4nica","family":"Klemz","sequence":"additional","affiliation":[{"name":"Brazilian Air Force Hospital,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlo Steiner","family":"Flores","sequence":"additional","affiliation":[{"name":"Brazilian Air Force Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Alberto","family":"Landeiro","sequence":"additional","affiliation":[{"name":"Brazilian Air Force Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/cncr.10252","article-title":"National cancer data base report on malignant paragangliomas of the head and neck","volume":"94","author":"Lee JH","year":"2002","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/1097-0142(19880815)62:4<686::AID-CNCR2820620407>3.0.CO;2-7","article-title":"High-voltage irradiation and combination chemotherapy for malignant pheochromocytoma","volume":"62","author":"Siddiqui MZ","year":"1988","journal-title":"Cancer","ISSN":"https:\/\/id.crossref.org\/issn\/0008-543X","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s007010170084","article-title":"Cranial neuroendocrine carcinoma primarily diagnosed as malignant paraganglioma with rapid progress to a fatal outcome","volume":"143","author":"Flitsch J","year":"2001","journal-title":"Acta Neurochir (Wien)","ISSN":"https:\/\/id.crossref.org\/issn\/0001-6268","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0046-8177(79)80008-8","article-title":"Paragangliomas of the head and neck region","volume":"10","author":"Lack EE","year":"1979","journal-title":"Hum Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0046-8177","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/BF01420312","article-title":"Cauda equina paraganglioma with subsequent intracranial and intraspinal metastases","volume":"138","author":"Roche PH","year":"1996","journal-title":"Acta Neurochir (Wien)","ISSN":"https:\/\/id.crossref.org\/issn\/0001-6268","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0046-8177(88)80314-9","article-title":"Decreased expression of neuropeptides in malignant paragangliomas: an immunohistochemical study","volume":"19","author":"Linnoila RI","year":"1988","journal-title":"Hum Pathol","ISSN":"https:\/\/id.crossref.org\/issn\/0046-8177","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"320","DOI":"10.3171\/jns.1991.75.2.0320","article-title":"Cervical paraganglioma with subsequent intracranial and intraspinal metastasis","volume":"75","author":"Blades DA","year":"1991","journal-title":"J. Neurosurg","ISSN":"https:\/\/id.crossref.org\/issn\/0022-3085","issn-type":"print"},{"key":"ref8","first-page":"333","article-title":"Chemodectoma with distant metastasis: case report and review of the literature","volume":"39","author":"Say CC","year":"1973","journal-title":"Am Surg","ISSN":"https:\/\/id.crossref.org\/issn\/0003-1348","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/00000658-196302000-00009","article-title":"Malignant carotid body tumors: report of a case","volume":"157","author":"Capt Reese HE","year":"1963","journal-title":"Ann. 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