{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T12:54:54Z","timestamp":1773752094444,"version":"3.50.1"},"reference-count":16,"publisher":"FapUNIFESP (SciELO)","issue":"3B","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2003,9]]},"abstract":"<jats:p>Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which has the pulmonary form as the most common presentation. Dissemination of the disease is common in immunocompromised patients, but immunodeficiency related to pregnancy severe enough to cause dissemination of the Mycobacteria is exceedingly rare. When dissemination occurs, any organ may be affected and in central nervous system, the infection presents as meningitis and single brain parenchyma tuberculomas. We report the case of a 17 year-old woman at the 34th week of pregnancy with respiratory and high intracranial pressure symptoms. On the day before admission she had a sudden onset of paraparesis and urinary retention and ten hours after the delivery she presented with paraplegia . The chest X-ray and CT scan were compatible with miliary tuberculosis. The cranial CT scan revealed numerous rounded hypodense lesions located at cerebral and cerebellar hemispheres, which presented ring-like enhancement after contrast injection. The patient underwent a craniotomy with biopsy of the lesions confirming the diagnosis of brain tuberculomas. The three-drug regimen was started and the cranial CT scan performed a year after diagnosis showed no brain lesions. We emphasize the aggressive dissemination of the disease in this case associated with pregnancy and the importance of early diagnosis and institution of therapy resulting in regression of the lesions.<\/jats:p>","DOI":"10.1590\/s0004-282x2003000500028","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T10:35:56Z","timestamp":1113561356000},"page":"855-858","source":"Crossref","is-referenced-by-count":15,"title":["Disseminated tuberculosis in a pregnant woman presenting with numerous brain tuberculomas: case report"],"prefix":"10.1590","volume":"61","author":[{"given":"Emerson L.","family":"Gasparetto","sequence":"first","affiliation":[{"name":"University of Parana School of Medicine,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscilla","family":"Tazoniero","sequence":"additional","affiliation":[{"name":"University of Parana School of Medicine,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnolfo de","family":"Carvalho Neto","sequence":"additional","affiliation":[{"name":"University of Parana School of Medicine,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1590\/S0004-282X1998000500012","article-title":"Fatores progn\u00f3sticos de letalidade na meningoencefalite tuberculosa","volume":"58","author":"Nunes C","year":"1998","journal-title":"Arq Neuropsiquiatr."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1590\/S0004-282X1996000200008","article-title":"Clinical and laboratory characteristics of 62 tuberculous meningoencephalites cases","volume":"54","author":"Nunes C","year":"1996","journal-title":"Arq Neuropsiquiatr","ISSN":"https:\/\/id.crossref.org\/issn\/0004-282X","issn-type":"print"},{"key":"ref3","first-page":"119","article-title":"Tuberculosis","volume":"1","author":"Campi de Castro C","year":"1991","journal-title":"Neuroimaging Clin N Am","ISSN":"https:\/\/id.crossref.org\/issn\/1052-5149","issn-type":"print"},{"key":"ref4","series-title":"Neuroimaging","first-page":"385","volume-title":"Viral and nonviral infections of the nervous system","author":"Magalh\u00e3es ACA","year":"1995"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/tropej\/47.1.5","article-title":"Tuberculous granulomas in childhood tuberculous meningitis: radiological features and course","volume":"47","author":"Ravenscroft A","year":"2001","journal-title":"J Trop Pediatr","ISSN":"https:\/\/id.crossref.org\/issn\/0142-6338","issn-type":"print"},{"key":"ref6","first-page":"199","article-title":"Neuroimaging of central nervous system tuberculosis in HIV-infected patients","volume":"7","author":"Whiteman MLH","year":"1997","journal-title":"Neuroimaging Clin N Am","ISSN":"https:\/\/id.crossref.org\/issn\/1052-5149","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/S0090-3019(01)00474-8","article-title":"Cavernous sinus tuberculoma: diagnostic difficulties in a personal case","volume":"55","author":"Rebai R","year":"2001","journal-title":"Surg Neurol","ISSN":"https:\/\/id.crossref.org\/issn\/0090-3019","issn-type":"print"},{"key":"ref8","series-title":"Robbins pathologic basis of disease","first-page":"697","volume-title":"The lung","author":"Kobzik L","year":"1999","edition":"6"},{"key":"ref9","first-page":"52","article-title":"Brain tuberculoma in Hong Kong","volume":"8","author":"Lee WY","year":"2002","journal-title":"HKMJ"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1086\/313989","article-title":"Clinical and radiological features of South African patients with tuberculomas of the brain","volume":"31","author":"Thonnell L","year":"2000","journal-title":"Clin Infec Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1212\/WNL.52.1.210","article-title":"Brainstem tuberculoma mimicking glioma: the role of antituberculous drugs as a diagnostic tool","volume":"52","author":"Del Brutto O","year":"1999","journal-title":"Neurology","ISSN":"https:\/\/id.crossref.org\/issn\/0028-3878","issn-type":"print"},{"key":"ref12","first-page":"1503","article-title":"Differentiation of tuberculous from pyogenic brain abscesses with in vivo proton MR spectroscopy and magnetization transfer MR imaging","volume":"22","author":"Gupta RK","year":"2001","journal-title":"Am J Neuroradiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/BF01405463","article-title":"Multiple tuberculomas of the brain: report of a case","volume":"32","author":"Capon A","year":"1975","journal-title":"Acta Neurochir (Wien)","ISSN":"https:\/\/id.crossref.org\/issn\/0001-6268","issn-type":"print"},{"key":"ref14","first-page":"265","article-title":"Reproductive Immunology","volume":"420","author":"Pearson H","year":"2002","journal-title":"Immunity's pregnant pause. Nature."},{"key":"ref15","first-page":"111","article-title":"CD4+ lymphocytes human immunodeficiency virus (HIV) infection: evidence for pregnancy-induced depression in uninfected and HIV-infected women","volume":"172","author":"Rich KC","year":"1995","journal-title":"J Infect Dis","ISSN":"https:\/\/id.crossref.org\/issn\/0022-1899","issn-type":"print"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0002-9378(78)90889-X","article-title":"Immunologic and medical considerations in tuberculin-sensitized pregnant patients","volume":"132","author":"Covelli HD","year":"1978","journal-title":"Am J Obstet Gynecol","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9378","issn-type":"print"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v61n3b\/17308.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T19:57:39Z","timestamp":1495655859000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X2003000500028&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":16,"journal-issue":{"issue":"3B","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["S0004-282X2003000500028"],"URL":"https:\/\/doi.org\/10.1590\/s0004-282x2003000500028","relation":{},"ISSN":["0004-282X"],"issn-type":[{"value":"0004-282X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,9]]}}}