{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:04:29Z","timestamp":1787612669110,"version":"build-2736575974"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p>Apresentamos um estudo das altera\u00e7\u00f5es an\u00e1tomo-funcionais do sistema nervoso central (SNC) de pacientes com transtorno aut\u00edstico (TA), atrav\u00e9s da resson\u00e2ncia nuclear magn\u00e9tica (RNM) e da tomografia computadorizada por emiss\u00e3o de f\u00f3ton \u00fanico (SPECT). Foram estudados 24 pacientes, sendo 15 (62,5%) do sexo masculino e 9 (17,5%) do feminino, com idade m\u00e9dia de 9 anos. Todos os pacientes foram submetidos \u00e0 RNM e apenas em 19 foi realizado o SPECT. Dos pacientes que realizaram RNM, 75% apresentaram altera\u00e7\u00f5es anat\u00f4micas e dos que realizaram o SPECT todos apresentaram altera\u00e7\u00f5es funcionais. As altera\u00e7\u00f5es anat\u00f4micas estavam preferencialmente localizadas no corpo caloso (25%), septo pel\u00facido (15,63%), ventr\u00edculos cerebrais (12,55%), cerebelo (9,38%), lobo temporal (6,25%), lobo occipital (6,25%) e hipocampo (6,25%). As altera\u00e7\u00f5es funcionais predominaram no lobo frontal (53,13%), lobo temporal (28,13%) , lobo parietal (15,63%) e nos n\u00facleos da base (3,13%). A presen\u00e7a de altera\u00e7\u00f5es an\u00e1tomo-funcionais do SNC n\u00e3o s\u00e3o priorit\u00e1rias para o diagn\u00f3stico, o qual deve ter sempre uma valida\u00e7\u00e3o cl\u00ednica.<\/jats:p>","DOI":"10.1590\/s0004-282x2003000600013","type":"journal-article","created":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T20:26:33Z","timestamp":1115929593000},"page":"957-961","source":"Crossref","is-referenced-by-count":8,"title":["Altera\u00e7\u00f5es an\u00e1tomo-funcionais do sistema nervoso central no transtorno aut\u00edstico: um estudo com RNM e SPECT"],"prefix":"10.1590","volume":"61","author":[{"given":"Marbene Guedes","family":"Machado","sequence":"first","affiliation":[{"name":"Universidade Federal de Sergipe, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9lio Ara\u00fajo","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sergipe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana","family":"Cipolotti","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sergipe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara Augusta Garcia Moreno","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sergipe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanoella Faro de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Sergipe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Moraes","family":"Donald","sequence":"additional","affiliation":[{"name":"CLIMEDI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam Peres de Oliveira","family":"Krauss","sequence":"additional","affiliation":[{"name":"DIAGNOSIS"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","series-title":"Paediatric neurology","volume-title":"Imaging in child Neurology","author":"Lord A","year":"1997","edition":"3"},{"key":"ref2","first-page":"32","article-title":"The secrets of autism: the number of children diagnosed with autism and Asperger's in the US. is exploding. 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