{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:48:38Z","timestamp":1769755718866,"version":"3.49.0"},"reference-count":13,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:p>OBJETIVO: \u00e9 relatar a efic\u00e1cia da vigabatrina no controle das convuls\u00f5es, bem como as altera\u00e7\u00f5es eletrencefalogr\u00e1ficas em crian\u00e7as com esclerose tuberosa e s\u00edndrome de West. M\u00c9TODO: Estudo retrospectivo, com dados cl\u00ednicos, de neuroimagem e de eletrencefalograma. RESULTADOS: Sete pacientes foram acompanhados e o tempo m\u00e9dio de seguimento foi 10 anos. Dos pacientes, quatro eram do sexo feminino e todos eram de cor branca. A m\u00e9dia de idade de in\u00edcio das convuls\u00f5es foi 3,4 meses. Todos usaram associa\u00e7\u00f5es de v\u00e1rios anticonvulsivantes; no m\u00ednimo duas drogas por esquema terap\u00eautico, e cada paciente utilizou pelo menos dois esquemas diferentes. O uso de vigabatrina como monoterapia ou em associa\u00e7\u00e3o iniciou em m\u00e9dia aos 7 anos de idade ou 4 anos ap\u00f3s in\u00edcio dos sintomas. Cinco dos sete pacientes que iniciaram vigabatrina ficaram sem crise. CONCLUS\u00c3O: Vigabatrina mostrou-se eficaz no controle das crises, levando a um melhor progn\u00f3stico.<\/jats:p>","DOI":"10.1590\/s0004-282x2003000600018","type":"journal-article","created":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T20:26:33Z","timestamp":1115929593000},"page":"988-990","source":"Crossref","is-referenced-by-count":2,"title":["Vigabarina no tratamento da epilepsia de dif\u00edcil controle em pacientes com s\u00edndrome de West e esclerose tuberosa"],"prefix":"10.1590","volume":"61","author":[{"given":"Newra Tellechea","family":"Rotta","sequence":"first","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre Rodrigues da","family":"Silva","sequence":"additional","affiliation":[{"name":"Hospital de Cl\u00ednicas de Porto Alegre,  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