{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T21:52:09Z","timestamp":1769809929752,"version":"3.49.0"},"reference-count":13,"publisher":"FapUNIFESP (SciELO)","issue":"2b","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>Several demyelinating disorders can affect children. The differential diagnosis between these diseases is usually an arduous task. Diagnostic criteria have been proposed for some of these disorders, however most of them have not yet been clinically and prospectively validated. Here we present a case of a ten year-old boy with recurrent bilateral optic neuritis and spinal cord involvement. Clinical and cerebrospinal fluid data have fulfilled diagnostic criteria for Devic's neuromyelitis optica (NMO). The differential diagnosis with multiple sclerosis (MS) has become troublesome since not only optic nerves and spinal cord were involved. In one of the relapses a left hemiparesis with facial involvement was registered. Magnetic resonance imaging was also compatible with MS. This case illustrates that CNS demyelinating disorders can fulfill diagnostic criteria for more than one demyelinating disease, making the clinical judgment an important tool in the management of these patients.<\/jats:p>","DOI":"10.1590\/s0004-282x2004000300032","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:38:22Z","timestamp":1113575902000},"page":"543-546","source":"Crossref","is-referenced-by-count":11,"title":["Recurrent neuromyelitis optica with diffuse central nervous system involvement: case report"],"prefix":"10.1590","volume":"62","author":[{"given":"Renan B.","family":"Domingues","sequence":"first","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo W.","family":"Kuster","sequence":"additional","affiliation":[{"name":"Santa Casa de Miseric\u00f3rdia, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1vio","family":"Lanes","sequence":"additional","affiliation":[{"name":"MULTISCAN, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagoberto","family":"Callegaro","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1055\/s-2002-36534","article-title":"Neuromyelitis optica","volume":"22","author":"Cree BAC","year":"2002","journal-title":"Semin Neurol","ISSN":"https:\/\/id.crossref.org\/issn\/0271-8235","issn-type":"print"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1212\/WNL.53.5.1107","article-title":"The clinical course of neuromyelitis otpica","volume":"53","author":"Wingerchuck 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(Paris)","ISSN":"https:\/\/id.crossref.org\/issn\/0035-3787","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.33588\/rn.2811.99064","article-title":"Esclerosis m\u00faltiple de inicio juvenil","volume":"28","author":"Silva A","year":"1999","journal-title":"Rev Neurol","ISSN":"https:\/\/id.crossref.org\/issn\/0210-0010","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1055\/s-2001-12219","article-title":"Long-term MRI observations of childhood-onset relapsing-remmiting multiple sclerosis","volume":"32","author":"Bal\u00e1ssy CS","year":"2001","journal-title":"Neuropediatrics","ISSN":"https:\/\/id.crossref.org\/issn\/0174-304X","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0022-3476(98)70371-3","article-title":"Juvenile multiple sclerosis: clinical and prognostic characteristics","volume":"132","author":"Pinhas-Hamiel O","year":"1998","journal-title":"J Pediatrics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1093\/brain\/120.11.2059","article-title":"Comparison of MR imaging criteria at first presentation to predict conversion to clinically definitive multiple sclerosis","volume":"120","author":"Barkhof F","year":"1997","journal-title":"Brain","ISSN":"https:\/\/id.crossref.org\/issn\/0006-8950","issn-type":"print"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ana.1032","article-title":"Recommended diagnostic criteria for multiple sclerosis: guidelines from the international panel on the diagnosis on multiple sclerosis","volume":"50","author":"McDonald IW","year":"2001","journal-title":"Ann Neurol","ISSN":"https:\/\/id.crossref.org\/issn\/0364-5134","issn-type":"print"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1212\/WNL.60.1.27","article-title":"New diagnostic criteria for multiple 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