{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T13:54:48Z","timestamp":1761400488393},"reference-count":10,"publisher":"FapUNIFESP (SciELO)","issue":"2b","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>Progressive encephalomyelitis with rigidity and myoclonus (PEWR) is a rare neurological disorder, characterised by muscular rigidity, painful spasms, myoclonus, and evidence of brain stem and spinal cord involvement. A 73-year-old white man was admitted with a 10-day history of painful muscle spasms and continuous muscle rigidity on his left lower limb. He had involuntary spasms on his legs and developed encephalopathy with cranial nerves signs and long tract spinal cord symptomatology. Brain CT scan and spinal MRI were normal. The CSF showed lymphocytic pleocytosis and no other abnormalities. EMG showed involuntary muscle activity with 2-6 seconds of duration, interval of 30-50 ms and a frequency of 2\/second in the left lower limb. Anti-GAD antibodies were detected in the blood. We detected radiological signs of lung cancer during the follow-up, which proved to be an oat cell carcinoma. The patient died two weeks after the diagnosis of the cancer.<\/jats:p>","DOI":"10.1590\/s0004-282x2004000300033","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:38:22Z","timestamp":1113575902000},"page":"547-549","source":"Crossref","is-referenced-by-count":20,"title":["Progressive encephalomyelitis with rigidity: a paraneoplastic presentation of oat cell carcinoma of the lung. Case report"],"prefix":"10.1590","volume":"62","author":[{"given":"Mariana","family":"Spitz","sequence":"first","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrique Ballalai","family":"Ferraz","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orlando G. P.","family":"Barsottini","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Alain","family":"Gabbai","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1136\/jnnp.54.5.449","article-title":"A case of progressive encephalomyelitis with rigidity and positive antiglutamic acid dehydrogenase antibodies","volume":"54","author":"Burn DJ","year":"1991","journal-title":"J Neurol Neurosurg Psychiatry","ISSN":"http:\/\/id.crossref.org\/issn\/0022-3050","issn-type":"print"},{"key":"ref2","first-page":"421","article-title":"Progressive fluctuating muscle rigidity and spasms, \"stiff-man\" syndrome: report of a case and some observations in 13 other cases","volume":"31","author":"Moersch FP","year":"1956","journal-title":"Mayo Clin Proc","ISSN":"http:\/\/id.crossref.org\/issn\/0025-6196","issn-type":"print"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1001\/archneur.1971.00480310050004","article-title":"Stiff-man syndrome and encephalomyelitis: report of a case","volume":"24","author":"Kasperek S","year":"1971","journal-title":"Arch Neurol","ISSN":"http:\/\/id.crossref.org\/issn\/0003-9942","issn-type":"print"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/brain\/99.1.27","article-title":"Progressive encephalomyelitis with rigidity: its relation to \"subacute myoclonic spinal neuronitis\" and to the \"stiff man syndrome\"","volume":"99","author":"Whiteley AM","year":"1976","journal-title":"Brain","ISSN":"http:\/\/id.crossref.org\/issn\/0006-8950","issn-type":"print"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/ana.410400315","article-title":"Progressive encephalomyelitis with rigidity responsive to plasmapheresis and immunosuppression","volume":"40","author":"Fogan L","year":"1996","journal-title":"Ann Neurol","ISSN":"http:\/\/id.crossref.org\/issn\/0364-5134","issn-type":"print"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1136\/jnnp.53.8.695","article-title":"Stiffman syndrome: a rare paraneoplastic disorder?","volume":"53","author":"Bateman DE","year":"1990","journal-title":"J Neurol Neurosurg Psychiatry","ISSN":"http:\/\/id.crossref.org\/issn\/0022-3050","issn-type":"print"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1136\/jnnp.50.5.628","article-title":"Segmental rigidity and spinal myoclonus as a paraneoplastic syndrome","volume":"50","author":"Roobol TH","year":"1987","journal-title":"J Neurol Neurosurg Psychiatry","ISSN":"http:\/\/id.crossref.org\/issn\/0022-3050","issn-type":"print"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1136\/jnnp.71.1.100","article-title":"Antibodies against glutamic acid decarboxylase: prevalence in neurological diseases","volume":"71","author":"H-M Meinck","year":"2001","journal-title":"J Neurol Neurosurg Psychiatry","ISSN":"http:\/\/id.crossref.org\/issn\/0022-3050","issn-type":"print"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1136\/jnnp.65.5.633","article-title":"Review of 23 patients affected by the stiff man syndrome: clinical subdivision into stiff trunk (man) syndrome, stiff limb syndrome, and progressive encephalomyelitis with rigidity","volume":"65","author":"Barker RA","year":"1998","journal-title":"J Neurol Neurosurg Psychiatry","ISSN":"http:\/\/id.crossref.org\/issn\/0022-3050","issn-type":"print"},{"key":"ref10","first-page":"853","article-title":"Stiff man syndrome and related conditions","volume":"17","author":"Meinck H","year":"2002","journal-title":"Mov Disord","ISSN":"http:\/\/id.crossref.org\/issn\/0855-3185","issn-type":"print"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v62n2b\/a33v622b.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T16:35:20Z","timestamp":1550075720000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X2004000300033&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":10,"journal-issue":{"issue":"2b","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["S0004-282X2004000300033"],"URL":"https:\/\/doi.org\/10.1590\/s0004-282x2004000300033","relation":{},"ISSN":["0004-282X"],"issn-type":[{"value":"0004-282X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}