{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T07:33:39Z","timestamp":1678952019183},"reference-count":28,"publisher":"FapUNIFESP (SciELO)","issue":"2b","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>Relatamos um caso de leucoencefalopatia multifocal progressiva, doen\u00e7a infecciosa desmielinizante do sistema nervoso central, seguido de revis\u00e3o da literatura. Comenta-se a import\u00e2ncia diagn\u00f3stica dos m\u00e9todos de imagem, bem como da an\u00e1lise do l\u00edquor e da t\u00e9cnica de rea\u00e7\u00e3o em cadeia da polimerase (PCR). At\u00e9 o presente momento, n\u00e3o h\u00e1 terapia efetiva para a condi\u00e7\u00e3o, com sobrevida m\u00e9dia de 1-6 meses nos pacientes n\u00e3o tratados; evolu\u00e7\u00e3o favor\u00e1vel pode ocorrer no subgrupo de pacientes que obt\u00e9m melhora da imunidade com o uso de terapia anti-retroviral.<\/jats:p>","DOI":"10.1590\/s0004-282x2004000300034","type":"journal-article","created":{"date-parts":[[2005,4,15]],"date-time":"2005-04-15T14:38:22Z","timestamp":1113575902000},"page":"550-554","source":"Crossref","is-referenced-by-count":1,"title":["Leucoencefalopatia multifocal progressiva confirmada por PCR para v\u00edrus JC no l\u00edquor: relato de caso"],"prefix":"10.1590","volume":"62","author":[{"given":"Alessandro Comar\u00fa","family":"Pasqualotto","sequence":"first","affiliation":[{"name":"Hospital Nossa Senhora da Concei\u00e7\u00e3o, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice J.Z. 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