{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T15:25:10Z","timestamp":1648567510459},"reference-count":12,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p>Se presenta un paciente de 62 a\u00f1os, sin antecedentes familiares de demencia, que a los 45 a\u00f1os debuta con crisis s\u00fabitas de disnea, visi\u00f3n borrosa, ca\u00edda al suelo y movimientos repetitivos de brazos. Tratado por epilepsia con fenito\u00edna y \u00e1cido valproico, repite espor\u00e1dicamente crisis semejantes. Hace 4 a\u00f1os sus familiares notan cambios de personalidad, irritabilidad y conductas obsesivas. Hace 2 a\u00f1os aparecen episodios de desorientaci\u00f3n de d\u00edas de duraci\u00f3n, algunos con alucinaciones auditivas y tambi\u00e9n fen\u00f3menos convulsivos. Ultimamente presenta crisis polimorfas, algunas con prolongada alteraci\u00f3n de conciencia, estados catatoniformes y relajaci\u00f3n esfinteriana. Examen f\u00edsico y neurol\u00f3gico sin anormalidades. Evaluaci\u00f3n neuropsicol\u00f3gica evidenci\u00f3 consistentes defectos en funciones frontales. EEG mostraron lentitud generalizada y actividad irritativa espor\u00e1dica en regiones frontotemporales. Atrofia cortical de predominio anterior en CT scan e hipoperfusi\u00f3n fronto-temporal bilateral en SPECT. Ex\u00e1menes de laboratorio y LCR normales. CONCLUSI\u00d3N: La asociaci\u00f3n de DFT con epilepsia, en forma no familiar, sugiere un s\u00edndrome neurodegenerativo cortical diferente.<\/jats:p>","DOI":"10.1590\/s0004-282x2005000600020","type":"journal-article","created":{"date-parts":[[2006,1,10]],"date-time":"2006-01-10T13:36:52Z","timestamp":1136900212000},"page":"1016-1020","source":"Crossref","is-referenced-by-count":3,"title":["Demencia frontotemporal no familiar y epilepsia generalizada"],"prefix":"10.1590","volume":"63","author":[{"given":"Patricio","family":"Fuentes","sequence":"first","affiliation":[{"name":"Hospital del Salvador,  Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Slachevsky","sequence":"additional","affiliation":[{"name":"Hospital del Salvador,  Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Reyes","sequence":"additional","affiliation":[{"name":"Hospital del Salvador,  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